CURRICULUM VITAE - Isped

CURRICULUM VITAE
Karen Leffondré
Date of birth: January 17, 1972 Bordeaux Segalen Univeristy
French citizenship ISPED
Two children INSERM U897, Biostatistics Department
146 Leo Saignat street
http://www.isped.u-bordeaux2.fr 33076 Bordeaux Cedex
Tel: 33-5-57-57-11-58
karen.leffondre@isped.u-bordeaux2.fr Fax: 33-5-56-93-05-72
EDUCATION
Year Degree Speciality University
1994 BSc equivalent Statistics - Econometrics European University of Brittany
1996 MSc equivalent Public health Paris-Sud University
1999 PhD Biostatistics Paris-Sud University (supervisor: Thierry Moreau, INSERM U780)
APPOINTMENTS
Year Position Institution Department
Primary affiliations
1999-2003 Post-doc McGill University Epidemiology and Biostatistics
2003-2008 Assistant Professor University of Montreal Social and Preventive Medicine
2008- Associate Professor Bordeaux Segalen University Bordeaux School of Public Health (ISPED)
INSERM U897 Biostatistics
Secondary affiliations
2003- Researcher Research Centre of the CHUM Health Risks
2011- Adjunct Professor University of Montreal Social and Preventive Medicine
AWARDS OBTAINED
Support
period Type of award
Funding source
Page 1 of 6
Total
amount
1995-1996 MSc Fellowship Académie de Versailles (France) 20 718 F
1996-1999 Doctoral Fellowship Association pour le développement de la recherche biomédicale (France) 33 480 F
1996-1999 Doctoral Fellowship Ministère de l’éducation nationale, de l’enseignement supérieur et de la recherche
(France)
266 400 F
1999-2000 International Fellowship La ligue nationale contre le cancer (France) 150 000 F
2000-2001 Postdoctoral Fellowship Montreal General Hospital, McGill University Health Center (Canada) 35 000 $
2001-2003 Postdoctoral Fellowship National Cancer Institute of Canada (NCIC), under the Program of Environmental
Epidemiology of Cancer (PREECAN)
49 500 $
2003-2004 Postdoctoral Fellowship Canadian Institutes of Health Research (CIHR) 64 000 $
2004-2008 Salary Award Fonds de recherche en santé du Québec (FRSQ) 193 404 $
RESEARCH GRANTS OBTAINED
Funding
Support period source Project title
As principal investigator
Total
amount
2004-2007 NSERC* New survival analytical methods for time-dependent covariates in case-control studies. 36 000 $
2004-2007 FRSQ De nouvelles méthodes d’analyse de la survie pour les études cas-témoins. 45 000 $
2004-2007 CIHR New survival analytic methods for time-dependent exposures in case-control studies. 60 340 $
2005-2008 CRCHUM Starting funds. 150 000 $
As co-investigator
2001-2003 CIHR Regression modelling of continuous covariates in epidemiology. 124 771 $
2004-2007 CIHR Optimal care trajectories in rheumatoid arthritis: the primary-secondary interface. 233 617 $
2005-2010 CIHR Occupational and selected non-occupational risk factors for lung cancer. 1 157 788 $
2008-2010 NCIC Development and validation of a lung cancer risk prediction model. 102 099 $
2008-2011 CIHR Investigating the role of the built environment in the development of obesity. 282 766 $
2010-2015 EC** (FP7) Systems biology towards novel chronic kidney disease diagnosis and treatment. 11 789 534 €
2010-2015 CIHR Occupational and selected non-occupational risk factors for lung cancer: analysis of a casecontrol
study in Montreal.
850 620 $
2010-2013 ANR*** Modèles biostatistiques dynamiques pour l’épidémiologie 264 215 €
* NSERC, Natural Sciences and Engineering Research Council of Canada
** EC, European Commission
*** ANR, French National Research Agency

Curriculum Vitae Karen Leffondré
TEACHING
University
Year
Program
Course
Cumulated
in class
hours
McGill 2000-2002 Summer Program in Epidemiology 513-660L Protocol development 24
Montréal 2002-2003 MSc Public Health MSO6060 Fundamentals of biostatistics 24
2004-2006 Pre-med MMD1007 Introduction to biostatistics 66
2005-2006 MD MMD2240 Clinical epidemiology 3
2007-2008 PhD Public Health SPU7010 Seminar in epidemiology 3
SPU7003 Seminar in epidemiology and biostatistics 15
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Distance
learning
Bordeaux 2008-2012 MSc Public Health PSP103 Protocol development 42
STA102 Inferential statistics 10 30
STA103 Introduction to statistical modeling 18
MSc Biostatistics STA203 Regression modeling strategies 45
STA209 Times series analysis 30
STA303 Anova and experimental designs 33
INF203 Numerical methods and algorithms 17
MSc Epidemiology STA201 Analysis of epidemiologic data* 138 9
INF105 Principles in statistics 30 15
EPI203 Analysis of surveillance data 12 6
PSP201 Advanced epidemiology 3 3
MSc tropEd Eramus Mundus STA202e Analysis of grouped longitudinal data in epidemiology 12
MSc Psycho-gerontology UE6 Statistics and health 24
MD UER Statistical modeling* 51
Diploma in Regression Module 2 Linear regression 72
Summer School in Epidemiology SURV Survival analysis 36
LOGR Introduction t the R software 12
* Mainly on linear regression, logistic regression, and survival analysis
RESEARCH TRAINEES SUPERVISED
Support
period
Student’s
name
University
Degree
Research project
1999-2000 L. MacDougall McGill MSc Epidemiol. Travel agents as partners in promoting healthier
travel.
My role
Member of
committee thesis
supervision
2003-2005 M. Mahmud McGill MSc Biostat. Flexible modelling of propensity score. Member of
committee thesis
supervision
2006-2008 Z. Cao Montreal MSc Biomedical
Sciences
New statistical methods for time-dependent
exposures in case-control studies.
2008-2009 A. Giraud Bordeaux MSc Public Health Exposure to asbestos and mesothelioma: first
analyses of a case-control study.
2008-2009 J. Bettaieb Bordeaux MSc Epidemiol. The impact of heat and air pollution on mortality in
Tunis in 2005-2007.
2009-2010 H. Gauvin Sherbrooke &
Montpellier 2
Supervisor
Supervisor
Co-supervisor
MSc Biostat. Variance estimator for a weighted Cox model. Supervisor
2009-2010 E. Legrand Bordeaux MSc Biostat. Comparison of unconditional and conditional logistic
regression for frequency matched case-control data.
2010- J. Boucquemont Bordeaux PhD Biostat. Development of statistical models for chronic kidney
disease.
2011-2012 L. Loubère Bordeaux MSc Biostat. Les trajectoires du déclin de la fonction rénale dans
la cohorte NephroTest
RESEARCH ASSISTANTS SUPERVISED
Support period RA name RA level Duration of employment
2005-2007 Y. Xiao MSc Biostatistics 2 years 0.6 FTE
2007-2010 W. Wynant MSc Applied Statistics 1 year 1.0 FTE + 6 months 0.4 FTE
2010 H. Gauvin MSc Biostatistics 2 months 1.0 FTE + 3 months 0.4 FTE
Supervisor
Supervisor
Supervisor
SERVICE
� Reviewer of grants applications (CIHR Public Health Grant Review Panel, Spring and Fall 2007, Spring 2010 competitions).
� Reviewer of articles for referred journals (Statistics in Medicine, Communications in Statistics – Theory and Methods).
� Reviewer of abstracts for international conferences (SER/CSEB 2005, ACFAS 2008, ISCB 2008).
� Member, Local Organizing Committee, 3rd International Biometrics Society Channel Network, Bordeaux, France, April 11-13, 2011. (160
participants)
� Member, Recruitment Committee 2011, Faculty of Pharmacy, University of Paris 11.

Curriculum Vitae Karen Leffondré
RESEARCH INTERESTS
• Survival analysis
• Design and analysis of case-control studies
• Modeling of occupational and environmental exposures
PUBLICATIONS
Published or accepted refereed papers
1. Leffondré K, Lellouch J, Com-Nougué C, Moreau T. Optimality of non-parametric tests for association between survival time and continuous
covariate. Communications in Statistics - Theory and Methods, 2001; 30(5):913-29.
2. MacDougall LA, Gyorkos TW, Leffondré K, Abrahamowicz M, Tessier D, Ward BJ, MacLean JD. Increasing referral of at-risk travellers to
travel health clinics: Evaluation of a health promotion intervention targeted to travel agents. Journal of Travel Medicine, 2001; 8(5):232-42.
3. Leffondré K, Abrahamowicz M, Siemiatycki J, Rachet B. Modeling smoking history: A comparison of different approaches. American Journal
of Epidemiology, 2002; 156(9):813-23.
4. Abrahamowicz M, Schopflocher T, Leffondré K, du Berger R, Krewski D. Flexible modeling of the exposure-response relationship between
long-term exposure to average levels of particulate air pollution and mortality in the American Cancer Society study. Journal of Toxicology and
Environmental Health Part A, 2003; 66(16-19):1625-54
5. Leffondré K, Abrahamowicz M, Siemiatycki J. Evaluation of Cox’s model and logistic regression for matched case-control data with timedependent
covariates: A simulation study. Statistics in Medicine, 2003; 22(24):3781-94.
6. Sewitch MJ, Leffondré K, Dobkin PL. Clustering patients according to health perceptions: Relationships to psychosocial characteristics and
medication nonadherence. Journal of Psychosomatic Research, 2004; 56(3):323-32.
7. Abrahamowicz M, du Berger R, Krewski D, Burnett R, Bartlett G, Tamblyn, R, Leffondré K. Bias due to aggregation of covariates in the Cox
regression model. American Journal of Epidemiology, 2004; 160(7):696-706.
8. Leffondré K, Abrahamowicz M, Regeasse A, Hawker GA, Badley EM, McCusker J, Belzile E. Statistical measures were proposed for
identifying longitudinal patterns of change in quantitative health indicators. Journal of Clinical Epidemiology, 2004; 57(10):1049-62.
9. Rachet B, Siemiatycki J, Abrahamowicz M, Leffondré K. A flexible modelling approach estimated the respective effects of different elements
of smoking behaviour on lung cancer risk. Journal of Clinical Epidemiology, 2004; 57(10):1076-85.
10. Vassiliou MC, Feldman LS, Andrew CG, Bergman S, Leffondré K, Stanbridge D, Fried GM. A global assessment tool for evaluation of
intraoperative laparoscopic skills. American Journal of Surgery, 2005; 190(1):107-13.
11. Fortes C, Mastroeni S, Leffondré K, Sampogna F, Melchi CF, Mazzoti E, Pasquini P, Abeni D, for the IDI Multipurpose Psoriasis Research on
Vital Experiences (IMPROVE) Study Group. Relationship between smoking and the clinical severity of psoriasis. Archives of Dermatology,
2005; 141(12):1580-4.
12. Mahmud M, Abrahamowicz M, Leffondré K, Chaubey YP. Selecting the optimal transformation of a continuous covariate in Cox’s regression:
Implications for hypothesis testing. Communications in Statistics – Simulation and Computation, 2006; 35(1):27-45.
13. Vassiliou MC, Ghitulescu GA, Feldman LS, Stanbridge D, Leffondré K, Sigman HH, Fried GM. The MISTELS program to measure technical
skill in laparoscopic surgery: Evidence for reliability. Surgical Endoscopy and Other Interventional Techniques, 2006; 20(5):744-7.
14. Leffondré K, Abrahamowicz M, Siemiatycki J, Xiao Y. Modeling smoking history using a comprehensive smoking index : Application to lung
cancer. Statistics in Medicine, 2006; 25(24):4132-46.
15. Ehrmann Feldman D, Bernatsky S, Haggerty J, Leffondré K, Tousignant P, Roy Y, Xiao Y, Zummer M, Abrahamowicz M. Delay in
consultation with specialists for persons with suspected new-onset rheumatoid arthritis: a population-based study. Arthritis and Rheumatism
(Arthritis Care and Research), 2007; 57(8):1419-25.
16. Ehrmann Feldman D, Bernatsky S, Abrahamowicz M, Roy Y, Xiao Y, Haggerty J, Leffondré K, Tousignant P, Duffy CM. Consultation with
arthritis specialists for children with suspected juvenile rheumatoid arthritis: a population-based study. Archives of Pediatrics & Adolescent
Medicine, 2008; 162(6):538-43.
17. Benedetti A, Abrahamowicz M, Leffondré K, Goldberg MS, Tamblyn R. Using Generalized Additive Models to Detect and Estimate Threshold
Associations. The International Journal of Biostatistics, 2009; 5(1):article 26.
18. Ehrmann Feldman D, Xiao Y, Bernatsky S, Haggerty J, Leffondré K, Tousignant P, Roy Y, Abrahamowicz M. Consultation with cardiologists
for persons with new-onset chronic heart failure: a population-based study. The Canadian Journal of Cardiology, 2009; 25(12):690-694.
19. Leffondré K, Wynant W, Cao Z, Abrahamowicz M, Heinze G, Siemiatycki J. A weighted Cox model for modelling time-dependent exposures
in the analysis of case-control studies. Statistics in Medicine, 2010; 29(7-8):839-850.
20. Bettaieb J, Toumi A, Leffondré K, Ben Alaya N, Boukthir A, Chlif S, Hajem S, Ben Salah A. Relation température-mortalité pour la ville de
Tunis: 2005-2007. Archives de l’Institut Pasteur de Tunis, 2010; 87(1-2) :75-83.
21. Queinec R, Beitz C, Contrand B, Jougla E, Leffondré K, Lagarde E, Encrenaz G. Copycat effect after celebrity suicides: results from the
French national death register. Psychological Medicine 2011; 41(3):668-71.
22. Lacourt A, Leffondré K, Gramond C, Ducamp S, Rolland P, Gilg Soit Ilg A, Houot M, Imbernon E, Févotte J, Goldberg M, Brochard P.
Estimation of the effects of temporal patterns of occupational asbestos exposure on the risk of pleural mesothelioma: results from a French
pooled case-control study. European Respiratory Journal 2012; 39(6):1304-12.
23. Encrenaz G, Contrand B, Leffondré K, Queinec R, Aouba A, Jougla E, Miras A, Lagarde E. The impact of the 98 football world cup on suicide
rates in France: results from the national death registry. Suicide and Life-Threatening Behavior 2012; 42(2):129-35.
24. Blanc-Lapierre A, Bouvier G, Gruber A, Leffondre K, Lebailly P, Fabrigoule C, Baldi I. Cognitive disorders and occupational exposure to
organophosphates: Results from the PHYTONER study. Accepted in American Journal of Epidemiology.
Submitted papers
25. Papadopoulos A, Guida F, Cénée S, Cyr D, Schmaus A, Radoï L, Paget-Bailly S, Carton M, Menvielle G, Woronoff AS, Sauleau EA,
Leffondré K, Luce D, Stücker I. Gender differences in lung cancer risk by cigarette smoking in France: The ICARE case-control study.
26. Gauvin H, Lacourt A, Leffondré K. On the proportional hazards model for case-control analyses of environmental and occupational exposures.
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Curriculum Vitae Karen Leffondré
27. Leffondré K, Touraine C, Helmer C, Joly P. Interval-censored time-to-event and competing risk with death: is the illness-death model more
accurate than the Cox model?
Published letters
1. Leffondré K, Abrahamowicz M, Siemiatycki J, Rachet B. The authors reply Re: “Modeling smoking history: A comparison of different
approaches”. American Journal of Epidemiology 2003; 158(4):393-394.
Book chapters
1. Helynck B, Leffondré K, Demillac R, Dabis F. Chapitre 26 : De l’hypothèse épidémiologique au schéma d’étude. In Epidémiologie de terrain :
Méthodes et Applications. Edited by Dabis F and Desenclos JC. John Libbey 2011. In Press.
2. Leffondré K, Desenclos JC, Dabis F. Chapitre 29 : Le bon groupe de comparaison en épidémiologie de terrain. In Epidémiologie de terrain :
Méthodes et Applications. Edited by Dabis F and Desenclos JC. John Libbey 2011. In Press.
3. Alioum A, Thiébault R, Leffondré K. Chapitre 33 : Analyses des données d’enquête avec appariement. In Epidémiologie de terrain : Méthodes
et Applications. Edited by Dabis F and Desenclos JC. John Libbey 2011. In Press.
Book review
1. Leffondré K. Le logiciel R : Maîtriser le langage, Effectuer des analyses statistiques; by Pierre Lafaye de Micheaux, Remy Drouilhet and
Benoit. Liquet. Statistique et Enseignement 2011; 2(2) :81-82.
Published technical reports
1. Abrahamowicz M, du Berger R, Krewski D, Burnett R, Bartlett G, Leffondré K. Ecological versus individual covariates in the Cox regression
model. Carleton University-University of Ottawa: Technical Report Series of the Laboratory for Research in Statistics and Probability, 2000;
Technical Report No. 341.
2. Abrahamowicz M, Schopflocher T, Krewski D, Leffondré K, du Berger R. Flexible modeling of dose-response relationship between long-term
average levels of particulate air pollution and mortality in the American cancer society study. Carleton University-University of Ottawa:
Technical Report Series of the Laboratory for Research in Statistics and Probability, 2000; Technical Report No. 347.
Published abstracts
1. Leffondré K, Abrahamowicz M, Rachet B, Siemiatycki J. Modeling smoking history: A comparison of different approaches. 2001 Congress of
Epidemiology (A Joint Meeting of ACE, APHA, CSEB, and SER), Toronto, Ontario, June 13-16, 2001. American Journal of Epidemiology
2001 (Suppl.); 153(11): S246.
2. Abrahamowicz M, Li G, Pilote L, Leffondré K, du Berger R. Assessing the effects of longitudinal within-subject changes in risk factors on
coronary heart disease mortality. 2001 Congress of Epidemiology, Toronto, Ontario, June 13-16, 2001. American Journal of Epidemiology 2001
(Suppl.); 153(11): S65.
3. Abrahamowicz M, du Berger R, Krewski D, Burnett R, Bartlett G, Leffondré K. Impact of using ecological covariates on Cox model’s
estimates. 2001 Congress of Epidemiology, Toronto, Ontario, June 13-16, 2001. American Journal of Epidemiology 2001 (Suppl.); 153(11):
S258.
4. Leffondré K, Abrahamowicz M, Siemiatycki J. Comparison of Cox’s model versus logistic regression for case-control data with time-varying
exposure: a simulation study. The 35 th Annual Meeting of the Society for Epidemiologic Research (SER), Palm Desert, California, June 18-21,
2002. American Journal of Epidemiology 2002 (Suppl.); 155(11): S48.
5. Abrahamowicz M, Esdaile JM, Fortin PR, Neville C, du Berger R, Leffondré K, Pilote L, Karp I. Longitudinal analyses of changes in
cardiovascular risk factors in systemic lupus erythematosus. American College of Rheumatology (ACR) Annual Scientific Meeting, New
Orleans, Louisiana, October 25-29, 2002. Arthritis & Rheumatism 2002 (Suppl.); 46(9):S56.
6. Abrahamowicz M, du Berger R, Krewski D, Burnett R, Bartlett G, Tamblyn, R, Leffondré K. Bias due to aggregation of covariates in the Cox
regression model. American College of Epidemiology (ACE) Annual Scientific Sessions, Chicago, Illinois, September 6-9, 2003. Annals of
Epidemiology 2003; 13(8):583.
7. Leffondré K, Abrahamowicz M, Hawker GA, Badley EM, Regeasse A, McCusker J, Belisle E. Longitudinal Patterns of Change in Disability in
Osteoarthiritis. ACR Annual Scientific Meeting, Orlando, Florida, October 23-28, 2003. Arthritis & Rheumatism 2003 (Suppl.); 48(9):1736.
8. Fortes C, Mastroeni S, Leffondré K, Sampogna F, Melchi CF, Mazzotti E, Pasquini P, Abeni D and IDI Multipurpose Psoriasis research on
Vital Experiences (IMPROVE). Smoking is associated with increased psoriasis. European Congress of Epidemiology, Porto, Portugal,
September 8-11, 2004. Journal of Epidemiology and Community Health 2004; 58(Suppl. 1):A100.
9. Abrahamowicz M, Fortin P, Pilote L, Neville C, du Berger R, Karp I, Leffondré K, Clark A, Esdaile J. Current corticosteroid use is an
independent risk factor for cardiovascular morbidity in systemic lupus. ACR Annual Scientific Meeting, San Antonio, Texas, October, 2004.
Arthritis & Rheumatism 2004 (Suppl.); 50(9):S192.
10. Leffondré K, Abrahamowicz M, Siemiatycki J. Modeling smoking history using an overall indicator of exposure. The Joint Meeting of the SER
and the Canadian Society for Epidemiology and Biostatistics (CSEB), Toronto, Ontario, June 27-30, 2005. American Journal of Epidemiology
2005 (Suppl.); 161(11):S69.
11. Feldman DE, Bernatsky S, Haggerty J, Tousignant P, Roy Y, Leffondré K, Abrahamowicz M. Referral to rheumatology in persons with
rheumatoid arthritis: A population-based study. ACR Annual Scientific Meeting, San Diego, California, November 12-17, 2005. Arthritis &
Rheumatism 2005 (Suppl.); 52(9):S400.
12. Leffondré K, Wynant W, Cao Z, Siemiatycki J. A comprehensive smoking index to model smoking history in cancer studies. The 41 st Annual
Meeting of the SER. Chicago, Illinois, June 24-27 2008. American Journal of Epidemiology 2008 (Suppl.); 167(11): S110.
13. Leffondré K, Joly P, Helmer C. The illness-death model for estimating the impact of risk factors on the risks of dementia and death in elderly
cohorts. The 43 th Annual Meeting of the SER, Seattle, Washington, June 23-26, 2010. American Journal of Epidemiology 2010 (Suppl.);
171(11):S143.
14. Karp I, Abrahamowicz M, Leffondré K, Siemiatycki J. Development of a method for assessment of risk of lung cancer. 3rd North American
Congress of Epidemiology, Montreal, Quebec, June 21-24, 2011. American Journal of Epidemiology 2011 (Suppl.); 173(11):S339.
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Curriculum Vitae Karen Leffondré
15. Wynant W, Siemiatycki J, Leffondré K. Advantages and limitations of the Comprehensive Smoking Index in cancer studies. 3rd North
American Congress of Epidemiology, Montreal, Quebec, June 21-24, 2011. American Journal of Epidemiology 2011 (Suppl.); 173(11):S1099.
16. Gauvin H, Leffondré K, Lacourt A. Proportional hazards models for estimating the effect of occupational exposures in case-control studies. 3rd
North American Congress of Epidemiology, Montreal, Quebec, June 21-24, 2011. American Journal of Epidemiology 2011 (Suppl.);
173(11):S1102.
Presentations at international conferences (in addition to the published abstracts above)
17. Leffondré K, Lellouch J, Com-Nougué C, Moreau T. Optimality of nonparametric tests for association between survival time and continuous
covariate. The Joint Meeting of the Statistical Society of Canada (SSC), Western North American Region of the International Biometric Society,
and Institute of Mathematical Statistics, Burnaby, British Colombia, June 10-14, 2001.
18. Abrahamowicz M, MacKenzie, T, Leffondré K, du Berger R, Siemiatycki J. Joint modelling of time-dependent and non-linear effects of
continuous predictors in survival analysis, with application to re-assess the impact of intensity of past smoking on the risks of lung smokers in
ex-smokers. The 17 th International Workshop on Statistical Modelling, Chania, Crete, July 8-12, 2002.
19. Leffondré K, Abrahamowicz M, Siemiatycki J. Comparison of Cox’s model versus logistic regression for case-control data with time-varying
exposure: a simulation study. The 16 th International Epidemiological Association (IEA) World Congress of Epidemiology, Montreal, Quebec,
August 19-22, 2002.
20. Rachet B, Siemiatycki J, Leffondré K, Abrahamowicz M. Exposure-response relationships between cigarette smoking and male lung cancer
from a case-control study in Montreal: generalized additive model approach. The 16 th IEA World Congress of Epidemiology, Montreal, Quebec,
August 19-22, 2002.
21. Leffondré K, Abrahamowicz M, Siemiatycki J. Definition of risk sets for Cox’s analysis of case-control data with time-varying exposures: a
simulation study. The 23 rd Annual Conference of the International Society for Clinical Biostatistics (ISCB), Dijon, France, September 9-13,
2002.
22. Leffondré K, Abrahamowicz M, Siemiatycki J. Modeling smoking history using an overall indicator of exposure. The 26 th Annual Conference
of the ISCB, Szeged, Hungary, August 21-25, 2005.
23. Abrahamowicz M, Sylvestre MP, Pilote L, Leffondré K. New method for handling residual confounding by severity in observational studies.
The 26 th Annual Conference of the ISCB, Szeged, Hungary, August 21-25, 2005.
24. Abrahamowicz M, Xiao Y, Leffondré K, Feldman D. Double-bootstrap-based inference for Cox proportional hazards analyses of clustered
censored survival data. The 3 rd International Association for Statistical Computing World Conference, Limassol, Cyprus, October 28-31, 2005.
25. Leffondré K, Wynant W, Cao Z, Abrahamowicz M. The Cox model for epidemiological case-control data: a simulation study. The joint
meeting of the SSC and the Société Française de statistique (SFdS). Ottawa, Ontario, May 25-29 2008.
26. Leffondré K, Wynant W, Cao Z, Abrahamowicz M, Siemiatycki J. A weighted Cox model for case-control data with time-dependant
exposures. The 29 rd Annual Conference of the ISCB. Copenhague, Danemark, August 17-21, 2008.
27. Lacourt A, Leffondré K, Gramond C, Ducamp S, Gilg Soit Ilg A, Chamming’s S, Goldberg M, Imbernon E, Févotte J, Houot M, Brochard P.
Estimation of the effects of temporal patterns of occupational asbestos exposure on the risk of pleural mesothelioma: results from a French
pooled case-control study. The 10 th International Conference of the International Mesothelioma Interest Group (IMIG), Kyoto, Japan, August
31–September 3, 2010.
28. Bettaieb J, Ben Alaya N, Leffondré K, Toumi A, Analitis A, Chlif S, Boukthir A, Ben Salah A. Association entre mortalité journalière et
température chaude dans la ville de Tunis. 4 ème congrès international d’épidémiologie ADELF-EPITER, Marseille, France, September 15-17,
2010.
29. Lacourt A, Leffondré K, Gramond C, Imbernon E, Goldberg M et Brochard P. Mésothéliome et amiante : étude des paramètres temporels
d’exposition professionnelle. 4 ème congrès international d’épidémiologie ADELF-EPITER, Marseille, France, September 15-17, 2010.
30. Joly P, Commenges D, Jacqmin-Gadda H, Leffondré K. Estimation of prevalence of dementia in France. The 25 th International Biometric
Conference. Florianopolis, SC, Brazil, December 5-10, 2010.
31. Touraine C, Leffondré K, Joly P. A comparison between the estimates of the regression parameters using an illness-death model and a two-state
survival model. The 3 rd International Biometrics Society Channel Network Conference. Bordeaux, France, April 11-13, 2011.
32. Gauvin H, Leffondré K, Lacourt A. Proportional hazards models for estimating the effect of occupational exposures in case-control studies.
The 32 nd Annual Conference of the ISCB, Ottawa, Ontario, August 21-25, 2011.
33. Encrenaz G, Contrand B, Leffondré K, Queinec R, Aouba A, Jougla E, Miras A, Lagarde E. The impact of the 98 football world cup on suicide
rates in France: results from the national death registry. The 26 th International Association for Suicide Prevention World Congress, Beijing,
China, September 13-17, 2011.
34. Kohl M, Leffondré K, Heinze G. Proportional and non-proportional subdistribution hazards regression with SAS. The 33 rd Annual Conference
of the ISCB, Bergen, Norway, August 19-23, 2012.
35. Boucquemont J, Metzger M, Heinze G, Leffondré K. The illness-death model to study progression of chronic kidney disease. The 33 rd Annual
Conference of the ISCB, Bergen, Norway, August 19-23, 2012.
Presentations at national conferences
36. Leffondré K, Moreau T, Com-Nougué C, Lellouch J. Association entre une durée de survie et une variable catégorielle ordonnée en présence
de censure. 29 èmes Journées de Statistique, Carcassonne, France, May 26-30, 1997.
37. Rachet B, Siemiatycki J, Leffondré K, Abrahamowicz M. Relations dose-réponse entre la fumée de cigarette et le cancer pulmonaire à partir
d'une étude cas-témoins à Montréal : estimations utilisant une modélisation flexible. Congrès INRS-Institut Armand Frappier, Sainte-Adèle,
Québec, November 1-3, 2001.
38. Sewitch MJ, Leffondré K, Dobkin PL. Identifying clusters of patients according to health perceptions: relationships to psychosocial
characteristics and non-adherence to medication. Selected Research Topics in GI Disease, Canadian Association of Gastroenterology / Astra
Research Symposium, Hockley Valley Resort, Ontario, November 1-3, 2002.
39. Toupin April K, Feldman DE, Bernatsky S, Haggerty J, Tousignant P, Leffondré K. Referrals to rehabilitation services made by
rheumatologists, Annual Scientific Conference of the Canadian Arthritis Network (CAN), Gatineau, Québec, November 2005.
40. Toupin April K, Feldman DE, Bernatsky S, Haggerty J, Tousignant P, Leffondré K. Referrals to rehabilitation services made by
rheumatologists, Annual Conference of the Canadian Association of Occupational Therapy (COAT), Montreal, Québec, June 1-3, 2006.
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Curriculum Vitae Karen Leffondré
41. Lacourt A, Leffondré K, Gramond C, Ducamp S, Gilg Soit Ilg A, Chamming's S, Goldberg M, Imbernon E, Févotte J, Houot M, Iwatsubo Y,
Brochard P. Mésothéliome et amiante : étiologie professionnelle chez les hommes. 31 ème congrès national de médecine et santé au travail,
Toulouse, France, June 1-4, 2010.
42. Lacourt A, Leffondré K, Gramond G, Ducamp S, Gilg Soit Ilg A, Houot M, Imbernon E, Févotte J, Goldberg M, Chamming’s S, Brochard P.
Mésothéliome et amiante : étude des paramètres temporels d’exposition chez les hommes, France. 13 ème colloque de l’association pour le
développement des études et recherches épidémiologiques en santé travail (ADEREST), Pont-à-Mousson, France, September 23-24, 2010.
43. Gauvin H, Leffondré K, Lacourt A. Proportional hazards models for estimating the effect of occupational exposures in case-control studies.
Canadian Cancer Research Conference, Toronto, Ontario, November 27-30, 2011.
Invited conferences or seminars
1. Association entre une durée de survie et une variable catégorielle ordonnée. Service de Biostatistique et d’Épidémiologie, Institut Gustave
Roussy, Villejuif, France, November 1997.
2. Association entre une durée de survie et une variable catégorielle ordonnée. Institut Fédératif de Recherche “Épidemiologie, Sciences-Sociales
et Santé Publique” (IFR 69), Villejuif, France, January 1998.
3. Modeling smoking history: A comparison of different approaches. Division of Clinical Epidemiology, Montreal General Hospital, McGill
University Health Center, Montreal, Quebec, November 2000.
4. Modeling smoking history: A comparison of different approaches. Centre for Clinical Epidemiology and Community Studies, Jewish General
Hospital, McGill University Health Center, Montreal, Quebec, November 2001.
5. Comparison of Cox’s model versus logistic regression for case-control data with time-varying exposure: a simulation study. Annual Meeting of
the of the Statistical society of Canada (SSC), Hamilton, Ontario, May 26-29, 2002
6. Comparison of Cox’s model versus logistic regression for case-control data with time-varying exposure: a simulation study. Département
d’Epidemiology et Biostatistique, INRS-Intitut Armand Frappier, Laval, Quebec, September 2002.
7. Le modèle de Cox pour l’analyse des données cas-témoins: une étude de simulations. Département de mathématiques et statistique, Université
de Montréal, Montréal, Québec, October 2002.
8. Analysis of case-control data with Cox's model. Division of Clinical Epidemiology, Montreal General Hospital, McGill University Health
Center, Montreal, Quebec, February 4, 2003.
9. La prise en compte des expositions variant au cours du temps dans les études épidémiologiques : exemple du tabagisme. Centre de recherche du
CHUM, Montreal, Quebec, February 11, 2003.
10. Cox's model versus logistic regression for case-control data with time-varying exposure. Division of Clinical Epidemiology, Royal Victoria
Hospital, McGill University Health Center, Montreal, Quebec, February 27, 2003.
11. La modélisation des expositions variant au cours du temps dans les études épidémiologiques : exemple de la consommation de tabac. Groupe de
recherche interdisciplinaire en santé, Université de Montréal, Montréal, Québec, February 7, 2005.
12. Modeling smoking history using a comprehensive exposure index: application to lung cancer. Biostatistics seminars, Department of
Epidemiology and Biostatistics, McGill University, Montréal, Québec, November 28, 2005.
13. Modeling lung cancer risk using a new comprehensive smoking index: application to two case-control studies carried out in Montreal. Division
of Clinical Epidemiology, Montreal General Hospital, McGill University Health Center, Montréal, Québec, March 14, 2006.
14. La modélisation des expositions variant au cours du temps dans les études épidémiologiques de type cas-témoins. Séminaires de biostatistique,
Institut Fédératif de recherche en santé publique, Villejuif, France, 23 octobre 2007.
15. The Cox model for the analysis of case-control data. Respiratory Epidemiology and Clinical Research Unit (RECRU), McGill University,
Montréal, Québec, January 25, 2008.
16. Comparaison du modèle "sain-malade-mort" et du modèle de Cox pour données censurées par intervalle : simulations et application à la
démence. Service de santé publique et d'information médicale, Hôpital de la Timone, Faculté de Médecine, Université de la Méditerranée,
Marseille, France, January 21, 2011.
17. Comparison of the illness-death model and standard survival models for interval-censored data: a simulation study and an application to
dementia. Center for Medical Statistics, Informatics, and Intelligent Systems, Medical University of Vienna, Vienna, Austria, May 11, 2012.
Workshop presentations
18. Initiation au logiciel R. Service de biologie clinique, Hôpital d’instruction des armées Robert Picqué, Bordeaux, France, May 2009 (9 hours).
19. Etudes cas-témoins nichées dans une cohorte et nouveaux schémas d’études. Séminaires d’épidémiologie clinique du Service d’information
médicale, Centre Hospitalier Universitaire de Bordeaux, Bordeaux, France, December 14, 2010 (1 hour).
20. Principles of biostatistics for biomedical research Seminar in biomedical research methods. National Institute of Public Health, Pristina, Kosovo,
February 14-16, 2011 (9 hours).
21. Analyse des données d’exposition dans les études cas-témoins. Séminaires d’épidémiologie clinique du Service d’information médicale, Centre
Hospitalier Universitaire de Bordeaux, Bordeaux, France, May 10, 2011 (1 hour).
22. Modèle de Cox, ajustement et adéquation (1 heure). Séminaires d’épidémiologie clinique du Service d’information médicale, Centre Hospitalier
Universitaire de Bordeaux, Bordeaux, France, December 13, 2011 (1 hour).
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