Institute for Research on Cancer and Ageing of Nice - Aeres

supported by strong research results. Other topics appear to be more advanced, specifically the work on miRNAs that
are associated with the development of diabetes. It would be of utmost importance to study the functional in vivo
relevance of these miRNAs in mouse models. The involvement of a recently hired scientist and the link to
cardiovascular research could be very beneficial <strong>for</strong> this research direction. Eventually, this could lead to the
evolution of a suitable successor <strong>for</strong> the present team leader, who may consider retirement in 4-5 years.
� Conclusion
� Summary
In summary, the research group (including the junior group) has a very good track record and works on a highly
important research topic, which is relevant <strong>for</strong> both aging and cancer. The new mechanistic studies on miRNAs in
diabetes development and cardiovascular disease appear highly attractive and if studied in appropriate in vivo models
could be highly successful.
� Strengths and opportunities
The visibility of the research group. The recent recruitment of a junior group leader who could play a major
role in the future development of the research project of the team. The new focus on miRNAs in the epigenetic
control of gene transcription, its role in diabetes development, and the consequences on cardiovascular disease that
represent a very attractive research topic.
� Weaknesses and threats
The possible retirement of the team leader in the next 4-5 years.
� Recommendations
The group publishes well but should try to get more high impact papers. Given the importance <strong>for</strong> aging and
cancer of this topic, it will be important to make plans <strong>for</strong> the continuation of the research program. If successful, the
project of the junior group leader could provide a solid basis <strong>for</strong> a long term perspective of the team.
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