Bioengineered Lactobacillus as Next Generation Probiotics
Bioengineered Lactobacillus as Next Generation Probiotics
Bioengineered Lactobacillus as Next Generation Probiotics
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Regulatory Considerations<br />
Environmental Persistence<br />
• No persistence in the environment<br />
Genetic Stability<br />
• The engineered strain is genetically stable<br />
Bacterial Transmission<br />
• No sexual transmission of L. jensenii from female to<br />
male macaques, n=2<br />
Availability of Rescue Therapy<br />
• Engineered <strong>Lactobacillus</strong> contain no antibiotic<br />
resistance marker<br />
• Engineered <strong>Lactobacillus</strong> cleared from colonized<br />
macaques using azithromycin <strong>as</strong> vaginal suppository
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