Bioengineered Lactobacillus as Next Generation Probiotics
Bioengineered Lactobacillus as Next Generation Probiotics
Bioengineered Lactobacillus as Next Generation Probiotics
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Current Focus<br />
Conduct pre-IND consultation with FDA on the use<br />
of bioengineered <strong>Lactobacillus</strong><br />
• Evaluate vaginal colonization, clearance, and biocontainment<br />
in human volunteers (Ph<strong>as</strong>e 0)<br />
─Use of bioengineered <strong>Lactobacillus</strong> with a<br />
surrogate marker (β-glucuronid<strong>as</strong>e)<br />
• Working with the MIP R33 Team<br />
Expand the platform, along with our lead program<br />
• Co-express HIV inhibitors (single or multiple strains)<br />
• Develop multipurpose microbicides against other STIs<br />
• Mucosal delivery of antigens<br />
Confirm bioactivity of in situ-expressed proteins<br />
Refine dosage forms/delivery to promote more<br />
efficient vaginal colonization
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