Bioengineered Lactobacillus as Next Generation Probiotics
Bioengineered Lactobacillus as Next Generation Probiotics
Bioengineered Lactobacillus as Next Generation Probiotics
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Strategy<br />
Commensal <strong>Lactobacillus</strong> species are<br />
important in host defense<br />
BV & STI’s are known cofactors for HIV<br />
transmission<br />
Our Strategy:<br />
• Select optimal human vaginal strains<br />
• Express potent HIV inhibitors at high levels<br />
• Develop technologies to preserve<br />
<strong>Lactobacillus</strong> <strong>as</strong> dry powder for ambient<br />
temperature storage<br />
• Promote high level and persistent vaginal<br />
colonization
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