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UNEP/FAO/RC/CRC.5/11/Add.2 Annex 2 Hexachlorobutadiene: Focused Summary. Biodegradation and bio-accumulation data of existing chemicals (by the Chemicals Evaluation and Research Institute, Japan: CERJ) http://qsar.cerij,orjp/cgibin/DEGACC/result_head.cgi?STRID=01401&LANG=ENG IPCS/EHC-156 http://www.inchem.org/documents/ehc/ehc/ehc156.htm ________________
The Japanese DNA for the PIC Convention would like to submit the following information on our notification of final regulatory action on Hexachlorobutadiene. 1. Introduction Focused Summary Hexachlorobutadiene a) The events that led to the regulatory action The government of Japan designated Hexachlorobutadiene as Class I Specified Chemical Substances under the Chemical Substances Control Law. b) Significance of regulatory action, eg one use or many uses, level or degree of exposure Since Hexachlorobutadiene was classified as Class I Specified Chemical Substance in April 2005, manufacture, import and use of Hexachlorobutadiene have been banned. c) An overview of the regulatory system of the notifying country if relevant The government of Japan anticipates that persistent and highly bio-accumulative chemical substances with long-term toxicity (e.g. PCBs) may cause irreversible environmental pollution and have adverse effects on human health or the environment. In order to prevent environmental pollution and adverse effects on human health, the Chemical Substances Control Law stipulates that hazardous properties of chemicals should be checked based on the existing knowledge or by the tests which are consistent with the methods of the OECD Test Guidelines, conducted by the OECD GLP facilities. The government designate the chemical substances that are identified as not-biodegradable (persistent) and bio-accumulative as Type I Monitoring Chemical Substances. Manufacturers and Importers of Type I Monitoring Chemical Substances are required to report the quantities they manufactured and imported. If a Type I Monitoring Chemical Substance is identified as having long-term toxicity for human beings and animals at the top of food chain (higher predators), the government designates that chemical substances as Class I Specified Chemical Substances and are subject to final regulatory action (ban on manufacture, import, and use). The Ministry of Health, Labour and Welfare, the Ministry of Economy, Trade and Industry and the Ministry of the Environment are responsible for these regulations of chemical substances which are persistent, highly bio-accumulative and toxic for long time. d) Scope of the regulatory action – precise description of the chemicals subject to the regulatory action Aforementioned in b), it has been banned that manufacture, import and use of Hexachlorobutadiene. 1
Page 1: UNITED NATIONS United Nations Envir
Page 7 and 8: INTERNATIONAL PROGRAMME ON CHEMICAL
Page 9 and 10: CONTENTS ENVIRONMENTAL HEALTH CRITE
Page 11 and 12: 8.7.3. Dermal exposure 8.7.4. Expos
Page 13 and 14: equested to communicate any errors
Page 15 and 16: further been used as a fluid in gyr
Page 17 and 18: was Adult male rats are less sensit
Page 19 and 20: 6 h/day), the NOAEL was 53 mg/m 3 .
Page 21 and 22: Boiling point 212 °C at 101.3 kPa
Page 23 and 24: waters Water extraction by gas chro
Page 25 and 26: wet weight Biota grinding with Na2S
Page 27 and 28: found regarding the amount of hexac
Page 29 and 30: 1976). It can be concluded that the
Page 31 and 32: through a food chain, was not obser
Page 33 and 34: nd (n=3) trace (n=1) 50-390 (r, n=2
Page 35 and 36: 1978 Germany, idem 10 20 (50-percen
Page 37 and 38: Table 5 (contd). Type of soil Year
Page 39 and 40: Invertebrates Plankton 1972-1973 Un
Page 41 and 42: Gadus morrhua (flesh) < 0.1 Gadus m
Page 43 and 44: English sole (liver) 1983-1984 USA,
Page 45 and 46: Cheese, eggs nd Meat (3 types) nd O
Page 47 and 48: enal accumulation, enzymes with acy
Page 49 and 50: Table 8 (contd). Species Route Dose
Page 51 and 52: was recovered in the bile, respecti
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far after the administration of [ 1
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The 21 °C. By 24 h the fish showed
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al. (1983) e Table 9 (contd). Pimep
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CaCO3/litre. The hatchability of em
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Rat oral 350 (323-377) Murzakayev (
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day The per in females at 1067 mg/m
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3, 10, 30 or 100 mg/kg feed. Using
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a positive reaction. The test was r
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dose level of 8.1 mg/kg body weight
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Test description Species/strain/cel
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Metabolite and abbreviation a Condi
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as not the authors to be of questio
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hexachlorobutadiene (200 or 300 mg/
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1984; Hook et al., 1983; Lock et al
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day) per day) per group per Rat (Wi
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et tetraethylammonium (Jaffe et al.
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histopathological examination (see
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of Hexachlorobutadiene is slightly
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is assumed to occur by a rather slo
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its use in some areas as a pesticid
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conjugate betalyase-mediated toxici
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muqueuses oculaires du lapin. Eur J
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and of halides to the guppy (Poecil
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PB fish toxicity studies. Part I: R
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with hexachlorobutadiene nephrotoxi
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and Oliver BG & Niimi AJ (1983) Bio
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37: Schrenk D, Dekant W, & Henschle
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The et mercapturic acid and other S
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les valeurs moyennes sont général
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des cet et aux on a observé des mo
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9.1 Evaluation des risques pour la
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mucha turbulencia. No produce hidr
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en Los En sin con órganos afectado
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En se agrícolas que utilizaban el
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RC - What is RC? - Rotterdam Convention

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