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Optical Projection Tomography (OPT) - Biomedicum Imaging Unit ...

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Quantitative Modeling<br />

Mesh for a Finite Element model<br />

of a limb bud<br />

Color encodes proliferation rate<br />

(blue high; red low)<br />

For the model we need:<br />

Gene Expression: what genes are<br />

expressed in what regions<br />

Morphology: the limb shape<br />

Tissue Motion: node movements<br />

between iterations<br />

Q: Given morphologies at t 1 & t 2 , what tissue motions are consistent with this?<br />

Q: Can proliferation rates alone account for measured morphology?

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