CURRICULUM VITAE - ETH Zürich

CURRICULUM VITAE
Date prepared: February 11, 2008
1. General Information
Name: Dr. sc. nat. Peter Manser
Address:
Thunstrasse 76
3400 Burgdorf
E-Mail: peter.manser@bluewin.ch
Phone: +41 34 424 17 07
Mobile: +41 79 484 97 41
Citizen of: Appenzell
Birth date: September 28 th , 1971
Married with Eveline Manser-Meier
Children Mara (2002), Silvan (2004)
Education:
1992 Matura Type C Kantonsschule Wohlen, AG
1998 Dipl. Phys. ETH with honor
Diploma thesis
Department of Physics, ETH Zurich
Verification of intensity modulated fields in conformal
radiotherapy (Supervisor: Prof. Dr. P. Rüegsegger)
2000 Dipl. NDS ETH in Medical
Physics
Diploma thesis
Department of Physics, ETH Zurich
Dose response relationship of the PortalVision TM aS500
(Supervisor: Prof. Dr. P. Rüegsegger)
2003 Dr. sc. nat. Department of Physics, ETH Zurich
Thesis title Verification of intensity modulated radiotherapy with an
amorphous silicon portal imaging device (Supervisors: Prof.
Dr. P. Rüegsegger, Prof. Dr. P. Niederer)
2004 Certification SSRMP Professional Certificate in Medical Physics by the Swiss
Society of Radiobiology and Medical Physics (SSRMP)
Institutional Appointments:
1997 – 1997 Research student, Proton therapy group (Dr. E. Pedroni), Paul Scherrer Institute (PSI),
Villigen
1998 – 1998 Research student, Institute for Biomedical Engineering (Prof. P. Rüegsegger), ETH
and University of Zurich
1998 – 2002 Graduate Research and Teaching Assistant, Institute for Biomedical Engineering
(Prof. P. Rüegsegger), ETH and University of Zurich
2002 – 2003 Graduate Research and Teaching Assistant, Institute for Biomedical Engineering
(Prof. P. Niederer), ETH and University of Zurich
2003 – 2003 Graduate Research Assistant, Division of Med. Radiation Physics (Dr. R. Mini),
Inselspital and University of Berne
2003 – today Medical Physicist, Division of Med. Radiation Physics (Prof. R. Greiner, Dr. R. Mini,
PD Dr. D. Aebersold), Inselspital and University of Berne
2003 – today Lecturer at the School for Radiotherapists (G. Grolimund), Berne
2004 – today Lecturer, “Block course on Dosimetry”, Department of Physics, ETH Zurich
2007 – today Lecturer, “Medizinische Physik in der Praxis”, Department of Physics, ETH Zurich
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Administrative Responsibilities:
1998 – today Organizer of the Master of Advanced Studies in Medical Physics ETH, Department of
Physics, ETH Zurich
Committee Assignments:
2007 – today Board Member of the Stiftungsrat Bernische Radiumstiftung, Berne
Awards and Honors:
1998 Dipl. Phys. ETH with honor, Department of Physics, ETH Zurich
2003 Best Poster Presentation, SASRO meeting, Geneva, (co-author)
2004 Varian Prize for Radiation Oncology by the SSRMP
2007 Best Poster Presentation, SASRO meeting, Aarau, (co-author)
Professional Societies:
2000 – today Member Swiss Society of Radiobiology and Medical Physics (SSRMP)
2001 – 2003 Student Member American Association of Physicists in Medicine (AAPM)
2004 – 2005
2005 – today
2003 – today
Junior Member
Full Member
Member
American Association of Physicists in Medicine (AAPM)
American Association of Physicists in Medicine (AAPM)
Swiss Professional Association of Medical Physicists (SPAMP)
2005 – today Member Scientific Association of Swiss Radiation Oncology (SASRO)
Professional Leadership Roles:
2004 – 2007 Member of the IMRT working group of the SSRMP
2004 Annual Conference of the SSRMP, Berne, Session Co-Chair
2005 Annual Conference of the SSRMP, Lausanne, Session Chair
2005 – today Member of the “QA of treatment planning systems” working group of the SSRMP
2007 Annual Meeting of SASRO, Aarau, Scientific Committee
2007 Dreiländertagung Medizinphysik 2007, Berne, Co-Organizer, Member of the Scientific
Committee, Session Co-Chair
Editorial Boards:
2006 Reviewer Zeitschrift für Medizinische Physik
2007 Reviewer Medical Physics
2007 Ad-hoc Reviewer Computerized Medical Imaging and Graphics
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2. Working, Research and Teaching Contributions
A. Narrative Report
Dr. P. Manser is a Medical Physicist at the Division of Med. Radiation Physics, Inselspital and University
of Berne. He graduated with honor at the Department of Physics at the Swiss Federal Institute of
Technology (ETH) Zurich, in 1998. He received his Ph.D. degree in Physics from ETH Zurich in 2003
under the guidance of Prof. P. Rüegsegger and Prof. P. Niederer. In 2004, he attained the Certification in
Medical Physics of the Swiss Society of Radiobiology and Medical Physics (SSRMP).
In his Ph.D. thesis, he investigated the verification of intensity modulated radiotherapy (IMRT) with an
electronic portal imaging device (EPID) and Monte Carlo methods. During the Ph.D. study, he worked
closely with the Division of Med. Radiation Physics, Inselspital and University of Berne and industrial
partners. The scientific impact of his investigations is expressed by a number of publications and
presentations on international and national conferences. Next to his Ph.D., he served as a research assistant
at the Division of Med. Radiation Physics, Inselspital and University of Berne. The project, he was
working on was the Swiss Monte Carlo Plan project of the Swiss Innovation Promotion Agency (CTI).
In 2003, Dr. Manser moved to Berne, where he works as a Medical Physicist for the Division of Med.
Radiation Physics, Inselspital and University of Berne. In 2004, Dr. Manser was board certified as a
Medical Physicist by SSRMP and his current position at the University of Berne is “Oberassistent”. His
main topics in clinical routine are intensity modulated radiotherapy (IMRT), image guided radiotherapy
(IGRT), treatment planning, brachytherapy, radiation protection, and computing and networks. Next to
clinical routine, Dr. Manser is engaged in research topics such as Monte Carlo methods in radiotherapy and
the development of enhanced brachytherapy concepts.
Since 1998, Dr. Manser has been involved in the organization of the post-graduate course in Medical
Physics (MAS ETH in Medical Physics) at ETH Zurich. This Master of Advanced Studies is targeted at
physicists who want to become medical physicists. At the moment, Dr. Manser is still engaged with the
organization of this master.
Dr. Manser is a lecturer at ETH Zurich where he is teaching medical physics for physics students. He is a
supervisor of a number of master theses at ETH Zurich. He is also teaching courses at the School for
Radiotherapists in Berne, Switzerland.
B. Funding Information
2007 – 2008 Research grant, Berner Radiumstiftung, “Herstellung eines Phantoms zur Modellierung
von Patientenbewegungen”, Co-Principal Investigator
2007 – 2009 Research grant, Varian Medical Systems Inc., “Electron Macro Monte Carlo for non-
Varian Machines”, Co-Investigator
C. Reports of Clinical Activities
2003 – today Treatment Planning
In radiotherapy, treatment planning is one major step towards successful therapy of
cancer patients. For this purpose, individual dose calculations are performed taking into
account the individual anatomy of the patient. In forward treatment planning, the plan is
optimized by the operator (e.g. by adjusting the beam energy and using different wedges
and beam angles). In contrast to this, inverse treatment planning aims to automatically
determine the required energy fluences for a given dose distribution. For this purpose,
optimization algorithms (typically iterative procedures) are implemented in modern
treatment planning systems. Currently, at the Division of Med. Radiation Physics, the
following planning systems are used in clinical routine: TMS, Masterplan, Eclipse, Plato,
RadCalc.
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2003 – today Computing and Networks
As a modern clinic, the clinic for radio oncology at Inselspital is based on a
contemporary computing and network system. Most important is the use of a clinical
information system. At the Division of Med. Radiation Physics, since November 2007,
the ARIA system from Varian Medical Systems is used.
2003 – today Patient Specific Quality Assurance
Quality assurance (QA) plays an important role in radiotherapy. One particular part of it
is the patient specific QA which aims to perform verification and documentation of the
treatment fields delivered to a patient. In order to do so, the physicist analyzes the
corresponding information. Typical tasks are the check of delivery parameters, the
matching of reference and portal images, the independent calculation of monitor units,
the verification of dose delivered to the patient (in vivo dosimetry).
2004 – today Brachytherapy
Brachytherapy aims to treat cancer patients by bringing a radioactive source nearly to or
even within the tumor tissue. Using this technique, many different tumor sites can be
treated. The role of the physicist in brachytherapy is determined by dosimetric purposes,
treatment planning as well as quality assurance and radiation safety.
2005 – today Intensity Modulated Radiotherapy (IMRT)
IMRT aims to tailor the dose distribution to the tumor while, simultaneously, organs-atrisk
are avoided. Using inverse treatment planning systems (Helios and Masterplan), the
so-called beamlets are optimized. The delivery of intensity modulated beams is
accomplished by the use of dynamic or static multileaf collimators.
2005 – today Radiation Protection
In a hospital such as the Inselspital, ionizing radiation is used for diagnostic as well as
therapeutic purposes. The Division of Med. Radiation Physics takes the lead of the
radiation protection at Inselspital.
2006 – today Image Guided Radiotherapy (IGRT)
IMRT must be accomplished by using IGRT techniques in order to guarantee that the
dose is delivered to the correct location. By this means, inter- and intrafraction motion
must be taken into account. An important issue in this context is the use of an electronic
portal imaging device (EPID) for online patient setup.
2007 – today Implementation of new equipment
In radiotherapy, it is of great importance to use equipment which is state-of-the-art and
which fits adequately to the hospital’s strategy. Thus, new equipment must be installed in
order to keep the therapy on a high level. Examples of installations are:
- Spring 2007: CT (Philips) for treatment planning purposes
- Summer 2007: Upgrade of treatment planning systems (Masterplan)
- Autumn 2007: Upgrade of clinical information system
- Winter 2007: Brachytherapy using permanent seeds
2007 – today Adaption of the clinic’s strategy
The clinic for radio oncology at Inselspital, Berne, has to define and modify its strategy
in terms of radiotherapy.
D. Reports of Research Activities
1998 – 1999 IMRT Verification Using the SLIC-EPID
Intensity modulated radiotherapy (IMRT) is a new technology which aims to deliver the
dose conformally to the tumor. It is a matter of common knowledge that IMRT leads to
steep dose gradients and that a special QA procedure is needed. In this project, a
scanning liquid-filled ionisation chamber (SLIC) electronic portal imaging device (EPID)
is investigated on its feasibility to measure portal dose distributions for dynamically
applied fields. For this purpose, a diploma thesis (P. Manser) was conducted which
showed the limits of this specific EPID to enable portal dosimetry for dynamically
applied fields. This project was a collaborative work between the Swiss Federal Institute
of Technology (ETH), Zurich, Switzerland and the Inselspital and University of Berne,
Switzerland.
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1998 – 2000 Multiple Source Model for Monte Carlo based Beam Model
The MC method is considered to be the most accurate method for dose calculations.
However, in order to calculate patient related dose distributions, accurate knowledge of
the beam characteristics is required. The aim of this project was to develop a Monte
Carlo (MC) based beam model for a Varian Clinac 2300 C/D for photon beams (6, 15
MV).
1999 – 2000 Dose Response of the PortalVision TM aS500
The PortalVision TM aS500 is based on amorphous silicon technology and has the
potential to measure portal dose images (PDI) for highly modulated treatment fields. This
makes it a very promising candidate for the verification of intensity modulated
radiotherapy (IMRT). In this project, the basic properties of this electronic portal
imaging device (EPID) are examined. For this purpose, the linearity and stability of this
EPID were analyzed. It was shown that next to its good short- and long-term stability, the
a-Si:H based EPID has a highly linear dose response relationship. This project was a
collaborative work between the Swiss Federal Institute of Technology (ETH), Zurich,
Switzerland and the Inselspital and University of Berne, Switzerland.
2000 – 2001 Monte Carlo simulation for intensity modulated radiotherapy
In order to perform Monte Carlo (MC) based dose calculations for intensity modulated
radiotherapy (IMRT), the multiple source model (see above) is supplemented by the
implementation of an 80-leaf multi leaf collimator (MLC). This allows the calculation of
dose distributions of static and dynamic MLC fields.
2000 – 2002 Measurements of portal dose images with an a-Si:H EPID
With the intention of dosimetric verification of intensity modulated radiotherapy
(IMRT), a pre-calculated and a measured portal dose image (PDI) are to be compared. In
this project, the suitability of using an a-Si:H EPID for measuring a PDI is investigated.
The results are compared with standard measurement devices such as point detectors
(ionization chamber) or two-dimensional detectors (film). This project was a
collaborative work between the Swiss Federal Institute of Technology (ETH), Zurich,
Switzerland and the Inselspital and University of Berne, Switzerland.
2000 – 2002 Investigations on the physical properties of an a-Si:H EPID using MC
In this project, the physical properties of an a-Si:H portal imaging device are investigated
using Monte Carlo (MC) simulations. For this purpose, the exact geometry of the EPID
is implemented in a GEANT based MC code and the energy response and the influence
of different detector components are investigated. In addition, a model of the transport of
optical photons was developed in order to characterize the physical properties of the
phosphor layer on portal dosimetry.
2001 – 2002 Impact of energy spectral changes on portal dosimetry
Highly modulated treatment fields (such as IMRT fields) lead to very small fields for a
substantial time during treatment delivery. As a consequence, the beam characteristics
such as spectral changes are changing. In order to enable highly accurate portal
dosimetry, these changes need to be known. For this purpose, the influence of energy
spectral changes on portal dosimetry is investigated.
2000 – 2002 Pre-Treatment verification of IMRT using an EPID and MC
The pre-treatment verification process encompasses the comparison between a precalculated
and a measured portal dose image (PDI). For the measurement, the a-Si:H
EPID is employed, whereas for the calculation the Monte Carlo (MC) method is used.
This project was a collaborative work between the Swiss Federal Institute of Technology
(ETH), Zurich, Switzerland and the Inselspital and University of Berne, Switzerland.
2002 – 2003 Dosimetric treatment verification of IMRT using an EPID and MC
In order to perform dosimetric treatment verification (in-vivo dosimetry) for IMRT, the
a-Si:H EPID is used to measure a portal dose image (PDI). This PDI is then compared to
a corresponding PDI obtained from Monte Carlo (MC) simulations. This project was a
collaborative work between the Swiss Federal Institute of Technology (ETH), Zurich,
Switzerland and the Inselspital and University of Berne, Switzerland.
2002 – 2004 Advanced EPID parameters for patient setup purposes
The aim of this project is to enable low-dose patient setup using an EPID. For this
purpose, the acquisition procedure of the EPID needs to be modified such that images are
obtainable with as low dose as possible. This project was a collaborative work between
the Swiss Federal Institute of Technology (ETH), Zurich, Switzerland and the Inselspital
and University of Berne, Switzerland.
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2002 – 2004 Advanced EPID dosimetry
The high-Z materials, commonly existing in a-Si:H based EPIDs, cause problems such as
an overresponse to low-energy photons. In this project, investigations on possible
improvements by different detector designs are carried out.
2003 – 2004 Clinical Monte Carlo treatment planning for photon beams
This project aims to develop clinical Monte Carlo (MC) treatment planning for photon
beams. Recently, this project was named as Swiss Monte Carlo Plan (SMCP)
demonstrating the fact that it is a collaborative work between different institutes in
Switzerland. This project is supported from the Swiss Innovation Promotion Agency
(CTI).
2004 – today Clinical Monte Carlo based radiotherapy treatment planning for IMRT
The project aims to include intensity modulated fields in Monte Carlo (MC) based
treatment planning. In addition, methods to adapt the existing beam model to individual
accelerators of the same type will also be developed. This project is a continuation of the
project mentioned above and is supported from the Swiss Innovation Promotion Agency
(CTI).
2006 – today Monte Carlo for Brachytherapy treatment planning
Typically, treatment planning in brachytherapy does not account for inhomogeneities,
which is in most situations a good approximation. However, in dedication conditions,
inhomogeneities are to be considered. For this purpose, Monte Carlo is best suited.
2007 – today Investigations on 4D radiotherapy
It is obvious that time needs to be considered in radiotherapy. A typical example is lung
cancer treatment where breathing induced motion has an impact on the dose distribution.
In this project, 4D radiotherapy is investigated by different aspects such as the
development of a dynamic phantom or the implementation of motion in Monte Carlo
methods. Parts of this project are supported from the Bernische Radiumstiftung.
2007 – today Electron Macro Monte Carlo for non Varian Machines
The project aims to extend the well-known eMC algorithm to other linear accelerators.
This project is supported by Varian Medical Systems.
E. Reports of Teaching Activities
Lectures, Courses:
1998 – 2002 Teaching assistant, “Medical Physics I & II”, Department of Physics, ETH Zurich
2003 – 2003 Teaching assistant, “Biomedical Engineering II”, Department of Information Technology
and Electrical Engineering, ETH Zurich
2003 – today Lecturer at the school for radiotherapists, Berne
2004 – today Lecturer, "Block Course on Dosimetry", Department of Physics, ETH Zurich
2005 – today Ad hoc Lecturer, “Medical Physics”, Department of Physics, ETH Zurich
2007 – today Lecturer, “Medizinische Physik in der Praxis”, Department of Physics, ETH Zurich
Advisory and Supervisory Responsibilities:
Certification for Medical Physics of SSRMP
2005 – 2008 D. Frauchiger, Inselspital Berne
2006 – 2009 D. Schmidhalter, Inselspital Berne
Post-Graduate Theses:
2004 M. Arnold, Medizinphysik NDS ETH, ETH Zurich, “Automatische Vermessung der
MLK-Lamellenposition mit Hilfe eines Portalbild-systems“
2004 R. Treier, Medizinphysik NDS ETH, ETH Zurich, “Die Bewegung der Samenbläschen
und ihr Einfluss auf die Bestimmung des Zielvolumens in der intensitätsmodulierten
Radiotherapie“
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2006 D. Frauchiger, Master of Advanced Studies in Medical Physics ETH, ETH Zurich,
“Implementationen von amorphen Silizum Detekor Geometrien in eine flexible Monte
Carlo Umgebung”
2006 D. Terribilini, Master of Advanced Studies in Medical Physics ETH, ETH Zurich,
“Dosisberechnung in der Brachytherapie mit Monte Carlo”
Graduate Theses:
2001 R. Barengo, Dipl. Phys, ETH, ETH Zurich, “Monte Carlo Simulation eines Portalbild
Detektors”
2001 R. Bühlmann, Dipl. Phys. ETH, ETH Zurich, „Portale Dosis in der intensitätsmodulierten
Radiotherapie“
2001 S. Figini, Dipl. Phys. ETH, ETH Zurich, “Monte Carlo Studie der spektralen
Empfindlichkeit eines Portalbild Detektors”
2002 R. Treier, Dipl. Phys. ETH, ETH Zurich, “Dynamisches Verhalten eines Portalbild
Detektors”
2003 M. Beyeler, Dipl. Phys. ETH, ETH Zurich, “Absolute Dosimetrie eines Monte Carlo
Therapieplanungssystems für Photonen”
2006 S. Fankhauser, Medizintechniker HF, Höhere Fachschule für Medizintechnik Sarnen,
Switzerland, „Entwicklung eines Software-Tools zur Qualitätssicherung von
medizinischen Beschleunigeranlagen“
2006 D. Schmidhalter, MSc in Physics, ETH Zurich, “Bewegliche Kollimatoren zur Reduktion
von Transmissions- und Leckstrahlung”
2006 N. Fuchs, MSc in Physics, ETH Zurich, “Modelle für den Monte Carlo Teilchentransport
in Kollimatoren”
2007 S. Andereggen, MSc in Physics, ETH Zurich, “Dosimetrische in vivo Qualitätssicherung
der intensitätsmodulierten Radiotherapie”
2007 S. Lindegger, MSc in Physics, ETH Zurich, “Berücksichtigung von
Patientenbewegungen in der Monte Carlo Therapieplanung”
2008 P. Salm, MSc in Physics, ETH Zurich
2008 R. Schildknecht, Medizintechniker HF, Höhere Fachschule für Medizintechnik Sarnen,
Switzerland
2008 S. Grundlehner, Medizintechniker HF, Höhere Fachschule für Medizintechnik Sarnen,
Switzerland,
Undergraduate Theses:
2003 M. Neis, Cand. Dipl. Phys. ETH, ETH Zurich, “Einfluss des Detektordesigns auf die
EPID Dosimetrie”
2005 L. Hirschi, Cand. Dipl. Phys. ETH, ETH Zurich, “Validierung der EDW auf Eclipse”
2006 S. Andereggen, Cand. Dipl. Phys. ETH, ETH Zurich, “Auswertetool für die in-vivo
Dosimetrie in der IMRT”
2006 S. Lindegger, Cand. Dipl. Phys. ETH, ETH Zurich, “Monte Carlo Simulation des
Backscatters in die Monitorkammer”
2007 T. Krayenbühl, MSc in Physics, ETH Zurich, “Investigations on skin toxicity for IMRT”
2007 Ch. Stoeck, MSc in Physics, ETH Zurich, “Re-calibration of a TLD system”
2007 K. Haller, MSc in Physics, ETH Zurich, “On the use of the dJaw method for clinical
cases”
Invited Talks:
1. P. Manser, Calculations and measurements of portal dose images in IMRT, Symposium on “New
Frontiers in Radiotherapy”, Berne, Switzerland, April 5, 2001
2. P. Manser, Portal dosimetry by the use of an EPID I, EPID Dosimetry Meeting, Rotterdam,
Netherlands, October 10, 2001
3. P. Manser, Portal dosimetry by the use of an EPID II, EPID Dosimetry Meeting, Leuven, Belgium,
January 25, 2002
4. P. Manser, Portal dosimetry by the use of an EPID III, EPID Dosimetry Meeting, Berne,
Switzerland, June 7, 2002
5. P. Manser, Photon application techniques, 5 th Zuppinger Symposium, Berne, Switzerland, June 28,
2006
6. P. Manser, Irradiation Techniques, SASRO/SSRMP Continuing Education, Lausanne, Switzerland,
November 15, 2006
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Conference Talks and Poster Presentations:
1. Verification of intensity modulated beams in radiotherapy, AAPM Annual Meeting, Nashville TN,
USA, 1999
2. Verification of intensity modulated beams in radiotherapy, VI International Conference on Medical
Physics, Patras, Greece, 1999
3. Verification of intensity modulated beams in radiotherapy using the PortalVision system, SASRO
Annual Meeting, St. Gallen, Switzerland, 2000
4. Dose response of the PortalVision TM aS500, SGSMP Annual Meeting, Basel, Switzerland, 2000
5. Calculations and measurements of portal dose images in IMRT, AAPM Annual Meeting, Salt Lake
City, Utah, USA, 2001
6. Monte Carlo investigations on portal dose measurements with an a-Si:H EPID, AAPM Annual
Meeting, Montreal, Quebec, Canada, 2002
7. Dose response of an a-Si:H EPID on static and dynamic photon beams, AAPM Annual Meeting,
Montreal, Quebec, Canada, 2002
8. Dynamic MLC and its impact on EPID dosimetry, Annual ESTRO Meeting, Prague, Czech
Republic, 2002
9. Dosimetric treatment verification of IMRT using an a-Si:H EPID and Monte Carlo simulations,
Joint Meeting SASRO-SGSMP, Geneva, Switzerland, 2003
10. Treatment verification of IMRT by the use of an a-Si:H EPID and Monte Carlo, World Conference
on Medical Physics and Biomedical Engineering, Sidney, Australia, 2003
11. An efficient framework for photon Monte Carlo treatment planning, Workshop on Monte Carlo
Treatment Planning, Ghent, Belgium, 2006
12. A flexible and comprehensive tool for hands-on training in medical physics, SASRO Annual
Meeting, Aarau, Switzerland, 2007
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3. Bibliography
Original Articles
1. M.K. Fix, M. Stampanoni, P. Manser, E.J. Born, R. Mini, and P. Rüegsegger, A multiple source
model for 6 MV photon beam dose calculations using Monte Carlo, Phys. Med. Biol., 46, 1407-
1427, 2001
2. M.K. Fix, P. Manser, E.J. Born, D. Vetterli, R. Mini, and P. Rüegsegger, Monte Carlo simulation
of a dynamic MLC: Implementation and applications, Z. Med. Phys., 11,163-170, 2001
3. M.K. Fix, P. Manser, E.J. Born, R. Mini, and P. Rüegsegger, Monte Carlo simulation of a dynamic
MLC based on a multiple source model, Phys. Med. Biol., 46, 3241-3257, 2001
4. D. Vetterli, H. Riem, D.M. Aebersold, R.H. Greiner, P. Manser, P. Cossmann, L. Kemmerling, E.J.
Born, R. Mini, Introduction of a novel dose saving acquisition mode for the PortalVision TM aS500
EPID to facilitate on-line patient setup verification, Med. Phys., 31, 828-831, 2004
5. J. Curschmann, P. Manser, M.R. Nuyens, C. Kolotas, Moderne Radiotherapie bei HNO-Tumoren,
Onkologie 4, 11-15,2005
6. M.K. Fix, P. Manser, D. Frei, W. Volken, R. Mini, E.J. Born, Efficient photon treatment planning
by the use of Swiss Monte Carlo Plan, Journal of Physics: Conference Series 74, 2007
7. D. Frauchiger, M.K. Fix, D. Frei, W. Volken, R. Mini, P. Manser, Optimizing portal dose
calculation for an amorphous silicon detector using Swiss Monte Carlo Plan, Journal of Physics:
Conference Series 74, 2007
8. D. Terribilini, P. Manser, D. Frei, W. Volken, R. Mini, M.K, Fix, Implementation of a
brachytherapy Ir-source in an in-house system and comparison of simulation results with EGSnrc,
VMC++ and PIN, Journal of Physics: Conference Series 74, 2007
9. D. Schmidhalter, M.K.Fix, P. Niederer, R. Mini, P. Manser, Leaf transmission reduction using
moving jaws for dynamic MLC IMRT, Med. Phys., 34, 3674-3687, 2007
10. M.K. Fix, P. Manser, D. Frei, W. Volken, R. Mini, E.J. Born, An efficient framework for photon
Monte Carlo treatment planning, Phys. Med. Biol., 52, N425-N437, 2007
11. W. Volken, D. Frei, P. Manser, R. Mini, E.J. Born, M.K. Fix, An integral conservative griddingalgorithm
using Hermitian curve interpolation, 2008, (submitted)
Proceeding Papers
1. M.K. Fix, P. Manser, H. Keller, E.J. Born, D. Vetterli, R. Mini, and P. Rüegsegger, Verification of
intensity modulated beams in radiotherapy, VI International Conference on Medical Physics,
Patras, Greece, (edited by Kappas et al.), 73-78, 1999
2. P. Manser, M.K. Fix, D. Vetterli, E.J. Born, R. Mini, and P. Rüegsegger, Dose response of the
PortalVision TM aS500, SGSMP Annual Meeting, Basel, Switzerland, (edited by Roth, Nemec,
Roser, Schnekenburger), 109-114, 2000
3. M.K. Fix, P. Manser, E.J. Born, D. Vetterli, R. Mini, and P. Rüegsegger, Monte Carlo simulation
for dynamic MLC: implementation and applications, SGSMP Annual Meeting, Basel, Switzerland,
(edited by Roth, Nemec, Roser, Schnekenburger), 153-159, 2000
4. D. Vetterli, E.J. Born, R. Mini, M.K. Fix, P. Manser, and P. Rüegsegger, Electronic portal
imaging: a useful tool in patient related QA for IMRT, 9 th Varian Users Meeting, Sardinia, 2001
5. P. Manser, M.K. Fix, E.J. Born, D. Vetterli, R. Mini, and P. Rüegsegger, Dosimetric treatment
verification of IMRT using an a-Si:H EPID and Monte Carlo simulations, Joint Meeting SASRO-
SGSMP, Geneva, Switzerland, 2003
6. D. Vetterli, L. Kemmerling, H. Riem, P. Manser, E.J. Born, R. Mini, and P. Rüegsegger, RadMode
portal imaging: a new acquisition mode for PortalVision TM aS500, Joint Meeting SASRO-SGSMP,
Geneva, Switzerland, 2003
7. E.J. Born, M.K. Fix, U. Gamper, P. Manser, S.P. Figini, C. Cris, D. Frei, R. Pfeiffer,
H. Neuenschwander, W. Volken, P. Niederer, and R. Mini, Towards clinical Monte Carlo
treatment planning for photon beams: first results, Joint Meeting SASRO-SGSMP, Geneva,
Switzerland, 2003
8. W. Volken, D. Frei, S.P. Figini, P. Manser, M.K. Fix, E.J. Born, H. Neuenschwander, and R. Mini,
Swiss Monte Carlo Plan: Beam Modifiers, 14 th ICCR Meeting, Seoul, Korea, 2004
9. D. Frauchiger, P. Manser, E.J. Born, and R. Mini, Comprehensive leaf motion files analysis of head
and neck and prostate IMRT treatment fields and its possible application in patient specific QA,
SSRMP Annual Meeting, Lausanne, Switzerland, 2005
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10. D. Schmidhalter, P. Manser, and M.K. Fix, Charakterisierung der Rückstreuung in die
Monitorkammer mittels Monte Carlo, Dreiländertagung Medizinphysik 2007, Berne, Switzerland
11. D. Schmidhalter, M.K. Fix, D. Frei, and P. Manser, Dynamische Sekundärkollimatoren zur
Reduktion von Transmissionsstrahlung während der IMRT, Dreiländertagung Medizinphysik 2007,
Berne, Switzerland
12. L. Hirschi, M.K. Fix, and P. Manser, Quellenmodel-Abstimmung eines 6 MV Photonenstrahls der
perkutanen Strahlentherapie, Dreiländertagung Medizinphysik 2007, Berne, Switzerland
13. R. Moeckli et al., Recommendations of the Swiss Society of Radiobiology and Medical Physics on
quality control for intensity-modulated radiation therapy Dreiländertagung Medizinphysik 2007,
Berne, Switzerland
Abstract Papers
1. M.K. Fix, P. Manser, H. Keller, E.J. Born, D. Vetterli, R. Mini, and P. Rüegsegger, Verification of
intensity modulated beams in radiotherapy, Med. Phys., 26, 1162, 1999
2. P. Manser, M.K. Fix, P. Rüegsegger, D. Vetterli, E.J. Born, and R. Mini, Verification of intensity
modulated beams in radiotherapy using the PortalVision system, SASRO Annual Meeting,
St. Gallen, Switzerland, 2000
3. P. Manser, R. Bühlmann, M.K. Fix, D. Vetterli, R. Mini, and P. Rüegsegger, Calculations and
measurements of portal dose images in IMRT, Med. Phys., 28, 1267, 2001
4. M.K. Fix, P. Manser, E.J. Born, R. Mini, and P. Rüegsegger, Monte Carlo simulation of dynamic
MLC using a multiple source model, Med. Phys., 28, 1197, 2001
5. P. Manser, M.K. Fix, S. Figini, R. Barengo, E.J. Born, R. Mini, and P. Rüegsegger, Monte Carlo
investigations on portal dose measurements with an a-Si:H EPID, Med. Phys., 29, 1316, 2002
6. P. Manser, R. Treier, H. Riem, M.K. Fix, D. Vetterli, R. Mini, and P. Rüegsegger, Dose response
of an a-Si:H EPID on static and dynamic photon beams, Med. Phys., 29, 1269, 2002
7. M.K. Fix, P. Manser, E.J. Born, R. Mini, and P. Rüegsegger, Influence of dynamic MLC on photon
beam energy spectra, Med. Phys., 29, 1270, 2002
8. D. Vetterli, E.J. Born, P. Cossmann, R. Mini, P. Manser, and P. Rüegsegger, IMRT verification in
clinical routine using portal imaging, Med. Phys., 29, 1271, 2002
9. P. Manser, M.K. Fix, E.J. Born, R. Mini, and P. Rüegsegger, Dynamic MLC and its impact on
EPID dosimetry, Radiother. Oncol. 64(S1), 2002
10. D. Vetterli, H. Riem, P. Manser, E.J. Born, R. Mini, and P. Rüegsegger, Gated portal imaging: a
new acquisition mode for PortalVision aS500, Radiother. Oncol. 64(S1), 2002
11. M.K. Fix, P. Manser, E.J. Born, R. Mini, and P. Rüegsegger, Changes in energy spectra using
dynamic MLC, SGSMP Annual Meeting, Gmunden, Austria, 2002
12. S.P. Figini, M.K. Fix, P. Manser, E.J. Born, D. Frei, W. Volken, H. Neuenschwander, P. Niederer,
and R. Mini, Towards clinical Monte Carlo treatment planning for photon beams: Swiss Monte
Carlo Plan, Med. Phys., 30, 1516, 2003
13. E.J. Born, M.K. Fix, S.P. Figini, P. Manser, D. Frei, W. Volken, H. Neuenschwander, P. Niederer,
and R. Mini, Towards clinical Monte Carlo treatment planning for photon beams: first results from
Swiss Monte Carlo Plan, World Conference on Medical Physics and Biomedical Engineering,
Sidney, Australia, 2003
14. P. Manser, M.K. Fix, E.J. Born, D. Vetterli, and R. Mini, Treatment verification of IMRT by the use
of an a-Si:H EPID and Monte Carlo, World Conference on Medical Physics and Biomedical
Engineering, Sidney, Australia, 2003
15. S.P. Figini, M.K. Fix, P. Manser, E.J. Born, D. Frei, W. Volken, H. Neuenschwander, and R. Mini,
Swiss Monte Carlo Plan: Blocks and Wedges, ESTRO Physics Meeting, Geneva, Switzerland,
2003
16. W. Volken, S.P. Figini, M.K. Fix, P. Manser, E.J. Born, H. Neuenschwander, D. Frei, and R. Mini,
Swiss Monte Carlo Plan: Multi Leaf Collimator, ESTRO Physics Meeting, Geneva, Switzerland,
2003
17. B. Isaak, G. Thalmann, J. Vock, C. Rentsch, P. Manser, R. Mini, R.H. Greiner, D.M. Aebersold,
Dosimetric Quality and Acute Toxicity in HDR-Brachytherapy As Monotherapy in Low Risk
Prostate Cancer, SASRO Annual Meeting, Basel, Switzerland, 2005
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18. B. Isaak, G.N. Thalmann, J. Vock, C.A. Rentsch, P. Manser, R. Mini, R.H. Greiner, C. Kolotas,
D.M. Aebersold, Dosimetrische Qualität und Akut-Toxizität in der HDR-Monotherapie
des Niedrig-Risiko-Prostatakarzinoms, Brachytherapie-Symposium der DEGRO/ÖGRO/SASRO,
Erlangen, Germany, 2005
19. P. Burri, P. Manser, L. Kemmerling, D. Vetterli, R. Bigler, R. Mini, R.H. Greiner, D.M. Aebersold,
Treatment of node-positive anal cancer by IMRT and simultaneous integrated boosts, SASRO
Annual Meeting, Sion, Switzerland, 2006
20. J. Vock, L. Kemmerling, D. Vetterli, P. Manser, R. Bigler, J. Tille, F. Behrensmeier, A. Omlin,
S. Thalmann, O. Matzinger, P. Gut, R. Mini, R.H. Greiner, D.M. Aebersold, Dose escalation by
IMRT and organ tracking in prostated cancer – acute and medium term toxicity, SASRO Annual
Meeting, Sion, Switzerland, 2006
21. M.K. Fix, P. Manser, D. Frei, W. Volken, R. Mini, E.J. Born, An efficient framework for photon
Monte Carlo treatment planning, Workshop on Monte Carlo Treatment Planning, Ghent, 2006
22. D. Frauchiger, M.K. Fix, D. Frei, W. Volken, R. Mini, P. Manser, Implementation of amorphous
silicon detector geometries in a flexible Monte Carlo environment, Workshop on Monte Carlo
Treatment Planning, Ghent, 2006
23. D. Terribilini, P. Manser, D. Frei, W. Volken, R. Mini, M.K. Fix, A flexible environment for Monte
Carlo brachytherapy planning, Workshop on Monte Carlo Treatment Planning, Ghent, 2006
24. P. Manser, M.K. Fix, E.J. Born, B. Isaak, D. Vetterli, M. Malthaner, R. Mini, A flexible and
comprehensive tool for hands-on training in medical physics, SASRO Annual Meeting, Aarau,
Switzerland, 2007
25. D. Schmidhalter, M.K. Fix, P. Manser, Reduction of leaf transmission by using moving jaws for
dynamic MLC IMRT, SASRO Annual Meeting, Aarau, Switzerland, 2007
26. S. Fankhauser, P. Manser, A new software tool for quality assurance of linear accelerators,
SASRO Annual Meeting, Aarau, Switzerland, 2007
27. M.K. Fix, P. Manser, D. Frei, W. Volken, F. Hasenbalg, R. Mini, E.J. Born, Interfacing SMCP to
Eclipse for photon MC treatment planning, SASRO Annual Meeting, Aarau, Switzerland, 2007
28. D. Terribilini, P. Manser, D. Frei, W. Volken, R. Mini, M.K. Fix, On the use of Swiss Monte Carlo
Plan in Brachytherapy: Impact of phantom shapes and inhomogeneities, SASRO Annual Meeting,
Aarau, Switzerland, 2007
29. D. Frauchiger, M.K. Fix, D. Frei, W. Volken, R. Mini, P. Manser, Using Swiss Monte Carlo Plan
for IMRT treatment verification based on EPID dosimetry, SASRO Annual Meeting, Aarau,
Switzerland, 2007
30. K. Loessl, R. Bigler, J. Tille, P. Manser, P. Gut, D. Aebersold, IMRT in advanced cervical cancer,
SASRO Annual Meeting, Aarau, Switzerland, 2007
Books, Chapters
Thesis
1. R. Moeckli et al., Quality control for intensity-modulated radiation therapy, Recommendation
No. 15, SSRMP, Switzerland, ISBN-3-908-125-41-3, 2007
2. Dreiländertagung Medizinphysik 2007, Bern, Abstracts, edited by M.K. Fix, P. Manser, R. Mini,
ISBN-3-908-125-42-1, 2007
1. P. Manser Verification of intensity modulated radiotherapy with an amorphous silicon portal
imaging device, Ph.D. thesis, ETH Zurich, Zürich, Switzerland, 2003
Media Appearance
1. P. Manser, A never ending debate on the World Congress 2000, Chicago: IMRT optimization,
delivery, and implementation, SGSMP Bulletin 2/2000, Nr. 42, 13, 2000
2. P. Manser, ESTRO 2003 – 7 th Biennial ESTRO Meeting on Physics and Radiation Technology for
Clinical Radiotherapy, SGSMP Bulletin 4/2003, Nr. 45, 2003
3. P. Manser, Postgraduate study in Medical Physics at ETH Zürich, One decade of experience,
SGSMP Bulletin 1/2004, Nr. 46, 2004
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4. P. Manser and T. Lomax, Master of Advanced Studies in Medical Physics at ETH Zurich, SGSMP
Bulletin 1/2006, Nr. 48, 2006
5. D. Aebersold, P. Manser, Intensitätsmodulierte Radiotherapie, Ärztemagazin Inselspital,
Herbst 2006
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