Hyperpolarized Nuclei for NMR Imaging and Spectroscopy - Lunds ...

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ived, including the thickness of the respiratory membrane and pulmonary perfusion. The method was employed to compare healthy control animals with animals with inflammatory lung injury. A significantly increased membrane thickness (10.0 µm vs. 8.6 µm) was measured in the latter group, whereas the pulmonary perfusion remained unaltered. By using hyperpolarized substances, novel possibilities of gaining physiological information arise, which may complement existing MRI and MRS techniques. vi
Original papers This thesis is based on the following papers, which will be referred to in the text by their Roman numerals. Papers I and III are reprinted with kind permission from the copyright owners: Acta Radiologica (Paper I) and Wiley-Liss, Inc. (Paper III). I Echo-planar MR Imaging of Dissolved Hyperpolarized 129 Xe: Potential for MR Angiography Månsson S, Johansson E, Svensson J, Olsson LE, Ståhlberg F, Petersson JS, Golman K Acta Radiol 2002; 43:455–460. II Hyperpolarized 13 C MR Angiography Using TrueFISP Svensson J, Månsson S, Johansson E, Petersson JS, Olsson LE Submitted to Magn Reson Med. III Quantitative Measurement of Regional Lung Ventilation Using 3 He MRI Deninger AJ, Månsson S, Petersson JS, Pettersson G, Magnusson P, Svensson J, Fridlund B, Hansson G, Erjefeldt I, Wollmer P, Golman K Magn Reson Med 2002; 48:223–232. IV 3 He MRI-based Measurement of Positional Dependence of Regional Pulmonary Ventilation in Rats Månsson S, Deninger AJ, Magnusson P, Pettersson G, Wollmer P, Golman K Manuscript. V Characterization of Diffusing Capacity and Perfusion of the Rat Lung in a Lipopolysaccaride Disease Model Using Hyperpolarized 129 Xe Månsson S, Wolber J, Driehuys B, Wollmer P, Golman K Submitted to Magn Reson Med. vii
Page 1: ��
Page 4 and 5: DOKUMENTDATABLAD enl SIS 61 41 21 O
Page 6 and 7: Doctoral Dissertation Department of
Page 9: Abstract Based on the principle of
Page 13 and 14: Table of Contents 1 Introduction .
Page 15 and 16: 1 Introduction The phenomenon of nu
Page 17 and 18: By using hyperpolarized imaging age
Page 19 and 20: vector addition of all the magnetic
Page 21 and 22: illustrates the difference between
Page 23 and 24: pumping process (Colegrove and Fran
Page 25 and 26: thetic effects, and has been used a
Page 27 and 28: 1 T 1,O2 p = ξ O2 [11] where ξ Xe
Page 29 and 30: 1 2 2 −6 ∝ γC γHrτ c. [17] T
Page 31 and 32: and thus breaks down at very low fr
Page 33 and 34: 230 mT, e.g., Tseng et al. 1998, Du
Page 35 and 36: lation-perfusion ratio (V · A/Q ·
Page 37 and 38: after gas inhalation, due to the wa
Page 39 and 40: tion of an NMR signal from a small
Page 41 and 42: larized gas with air took place as
Page 43 and 44: Table 5. Parameters of the imaging
Page 45 and 46: The images were evaluated with resp
Page 47 and 48: partial pressure present within the
Page 49 and 50: 3.8.2 Measurement procedure The spe
Page 51 and 52: 4.2 Vascular imaging of a 13 C-base
Page 53 and 54: gions. In central lung areas, regio
Page 55 and 56: 4.5 Diffusion capacity and perfusio
Page 57 and 58: 5 Discussion In this thesis, three
Page 59 and 60: due to the increased demand on the
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5.3 Hyperpolarized 3 He ventilation
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a theoretical T 1 of ∼38 min in t
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eath-holding periods during, e.g.,
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6 Conclusions The phantom study in
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8 References ABRAGAM A, GOLDMAN M.
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CHEN XJ, MÖLLER HE, CHAWLA MS, COF
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GIERADA DS, SAAM B, YABLONSKIY D, C
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KAUCZOR HU, HANKE A, VAN BEEK EJ. A
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OLSSON LE, MAGNUSSON P, DENINGER AJ
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TILTON RF, JR., KUNTZ ID, JR. Nucle
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Paper I
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formance of the gradient system, si
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S. MÅNSSON ET AL. Fig. 2. a-h) EPI
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though several technical issues rem
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Hyperpolarized 13 C MR angiography
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Introduction The most widespread te
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of the gradient moments prior to ea
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Methods Polarization procedure The
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secutive trueFISP images were acqui
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also to several other sources such
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low γ of 13 C reduces the sensitiv
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9. Chawla MS, Chen XJ, Möller HE,
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My 1 0.8 0.6 0.4 0.2 0 0 50 100 150
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Signal [a.u] 100 90 80 70 60 50 40
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a b Figure 5. Series of angiograms
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Paper III
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224 Deninger et al. FIG. 1. Sketch
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226 Deninger et al. FIG. 2. Coronal
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228 Deninger et al. FIG. 6. Histogr
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230 Deninger et al. FIG. 9. Monte C
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232 Deninger et al. 5. Gur D, Draye
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3 He MRI-based measurement of posit
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Introduction It is well known that
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3 He imaging All experiments were p
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coefficients b 1 and b 2, respectiv
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Using VI data after subtraction of
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To investigate whether the calculat
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14. Gur D, Drayer BP, Borovetz HS,
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Table 1. Gradient of VI [cm −1 ]
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Cycle 1 Cycle 2 Cycle 3 Cycle 4 2 s
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a Prone Ventilation index c Supine
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a Prone Supine 0 b 1 R 2 Prone Supi
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Paper V
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Abstract The ability to quantify pu
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lation and perfusion information by
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Applying the conditions at the inne
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where L is obtained from Eq. [8]. V
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After tracheal intubation, the anim
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Parametric analysis The fit of the
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in the LPS-treated group is consist
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3. Worsley DF, Palevsky HI, Alavi A
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enin activity in rats chronically e
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V-20 blood without Xe C a V a (t) L
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V-22 Error in estimated diffusion l
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V-24 NMR Ventilator repetition loop
Page 176:
Figure 7. The peak amplitudes (circ
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