Hyperpolarized Nuclei for NMR Imaging and Spectroscopy - Lunds ...

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Hyperpolarized Nuclei for NMR Imaging and Spectroscopy Methodology and model studies of lung and vascular function Sven Månsson Tekn. lic. Akademisk avhandling som, för avläggande av teknologie doktorsexamen vid tekniska fakulteten vid Lunds Universitet, kommer att offentligen försvaras fredagen den 13 december 2002, kl 10.15, i hörsal E:1406, E-huset, Lunds Tekniska Högskola, Lund. Fakultetsopponent: Professor Axel Haase, Institute of Physics, University of Würzburg, Germany.
Page 1: ��
Page 5 and 6: Hyperpolarized Nuclei for NMR Imagi
Page 7: To Maria To Alexander To my parents
Page 10 and 11: ived, including the thickness of th
Page 12 and 13: Abbreviations and Symbols 2D Two-di
Page 14 and 15: x 3.6 Vascular imaging of a 13 C-ba
Page 16 and 17: The hyperpolarization techniques in
Page 18 and 19: 2 Background 2.1 NMR physics 2.1.1
Page 20 and 21: 6 N m = exp( Em kBT) + I exp( Ei kB
Page 22 and 23: sate for the low concentration. To
Page 24 and 25: 2.2.3 The DNP method Dynamic nuclea
Page 26 and 27: 2.4.1 T 1 relaxation mechanisms for
Page 28 and 29: tion rates at room temperature have
Page 30 and 31: of interest, the applied magnetic f
Page 32 and 33: calculating the field strength at w
Page 34 and 35: Bergin et al. 1993). In 1994, the f
Page 36 and 37: 22 250 RBC A (brain gray matter?) 2
Page 38 and 39: 3 Methods 3.1 Hyperpolarization equ
Page 40 and 41: 3.2 Mechanical ventilator for hyper
Page 42 and 43: educe the influence of B 0 inhomoge
Page 44 and 45: 3.4 Animals The in vivo experiments
Page 46 and 47: 3.6.2 In vivo trueFISP imaging Imag
Page 48 and 49: 3.8.1 The alveolar diffusion model
Page 50 and 51: 4 Results 4.1 Inves tigation of dis
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the kidneys are visualized. The SNR
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Figure 14. Signal intensities in im
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Table 6. Summary of parameters calc
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are presented in Figure 16, which c
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elaxation were not included in the
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ing 3 He was located about 1.5 m fr
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2002) to 3 He MRI of humans have be
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ing a free induction decay (FID) si
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7 Acknowledgements The writing of a
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BLOCH F, HANSEN WW, PACKARD M. The
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DURAND E, GUILLOT G, DARRASSE L, TA
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HARRIS RK. Nuclear magnetic resonan
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MERBACH A, TÓTH É (eds). The Chem
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SAAM B, HAPPER W, MIDDLETON H. Nucl
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WOESSNER DE. Relaxation effects of
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Acta Radiologica 43 (2002) 455-460
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ECHO-PLANAR MR IMAGING OF DISSOLVED
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ECHO-PLANAR MR IMAGING OF DISSOLVED
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Paper II
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Abstract A 13 C-enriched water-solu
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concentration, makes this substance
Page 96 and 97:
II-6 M = E M M = E M zn , 1 zn ,
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A trueFISP pulse sequence was imple
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Results In vitro experiments The T
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The T 2 of the 13 C-based CM is ver
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Conclusion MR angiograms with high
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19. Hall DA, Maus DC, Gerfen GJ, In
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Figure 2. The maximum echo amplitud
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II-20 Relative SNR 300 200 100 0 0
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Figure 6. The first image in a seri
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FULL PAPERS Quantitative Measuremen
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Quantitative Lung Ventilation Using
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Page 121 and 122:
Page 123 and 124:
Page 125:
Paper IV
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Abstract A recently developed metho
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ventilation, defined as the relativ
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value of approximately 2.6 bar⋅s
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cients b 1 for the linear fit and b
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In several investigations, vertical
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References 1. Mure M, Domino KB, Li
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24. Saam B, Happer W, Middleton H.
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Table 2. Correlation coefficient (R
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a coronal sagittal axial b coronal
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a b Prone Supine Prone Supine IV-20
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Number of voxels with R 2 > 0.6 IV-
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Characterization of diffusing capac
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Introduction Gas transfer from ambi
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The diffusion coefficient, D, of xe
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tions in tissue, plasma and red blo
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Methods Polarization and administra
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Parametric analysis The data analys
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is inversely proportional to the ga
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prospect of more comprehensive char
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12. Ruppert K, Brookeman JR, Hagspi
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Table 1. Summary of the calculated
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Xe concentration (mM) 7.0 � �
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NMR-signal S a (0) S a0 S t0 S b0 s
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lood Increasing delay tissue 250 20
Page 178:
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