Module I Oxidation Reactions - NPTel
Module I Oxidation Reactions - NPTel
Module I Oxidation Reactions - NPTel
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NPTEL – Chemistry – Reagents and Organic reactions<br />
2.1.3.3 <strong>Oxidation</strong> of Amines<br />
Scheme 9<br />
The oxidation of amines can lead to various products depending on the nature of<br />
the starting compound. This section describes the oxidation of amines to imines<br />
and amides (Scheme 10).<br />
Ph-CH 2-NH-Ph<br />
NMe 2<br />
MnO 2/C 6H 6<br />
81 o C<br />
MnO 2/CHCl 3<br />
18 h/RT<br />
Scheme 10<br />
2.1.3.3 <strong>Oxidation</strong> of Hydrazo Compounds<br />
Ph-CH=N-Ph<br />
Me CHO<br />
N<br />
Hydrazobenzene can be oxidized to azobenzene with high yield (Scheme 11).<br />
Ph-NH-NH-Ph<br />
MnO 2/C 6H 6<br />
24 h/ 81 o C<br />
Scheme 11<br />
2.1.3.4 Oxidative Cleavage of 1,2-Diols<br />
Ph-N=N-Ph<br />
97% yield<br />
1,2-Diol undergoes oxidative cleavage to afford aldehydes or ketones (Scheme<br />
12).<br />
Joint initiative of IITs and IISc – Funded by MHRD Page 20 of 122
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