Low-Valent Titanium Induced Carbonyl Coupling Reactions
Low-Valent Titanium Induced Carbonyl Coupling Reactions
Low-Valent Titanium Induced Carbonyl Coupling Reactions
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R 1<br />
R 2<br />
N<br />
CH 3<br />
Table 9. <strong>Titanium</strong> induced synthesis of zindoxifen and analogues<br />
R 4<br />
R 1 R 2 R 3 R 4<br />
67a OAc H OAc Et<br />
67b OH H OH Et<br />
67c OH OH OH Me<br />
67d<br />
OMe OMe OMe Me<br />
1.5 Synthesis of 2-Quinolones<br />
68<br />
R 1<br />
NH<br />
O<br />
O<br />
O<br />
R 2<br />
TiCl 3/Zn<br />
THF , reflux<br />
Table 10. <strong>Low</strong>-valent titanium induced 2-quinolone synthesis<br />
Entry Yield (%)<br />
1<br />
2<br />
R 1 R2<br />
H<br />
R 3<br />
Me Ph 80<br />
3 Ph Ph 68<br />
4 Ph Me 69<br />
5 Me 2-Thienyl 50<br />
6 OMe OH 41<br />
Ph<br />
64<br />
69<br />
R 1<br />
N<br />
H<br />
R 2<br />
O<br />
31
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