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Anal and Rectal Cancers - ASTRO

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Potential Limitations of IMRT<br />

• Highly conformal fields with steep dose fall off<br />

may underdose nodal regions at risk<br />

• Potential for higher regional failure rates<br />

• Cautionary report from McGill<br />

– 66 pts treated for anal SCC (40-3DCRT, 26 IMRT)<br />

– Increased Grade 3+ BM toxicity in IMRT grp (42% v<br />

17.5%)<br />

– 1 yr LR rate: 28.6% (IMRT) v. 15.2% (3DCRT)<br />

VVuong, PProc ASCO, ASCO 2008

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