Chinese Medicine - Modern Practice (252 pages)
Chinese Medicine - Modern Practice (252 pages)
Chinese Medicine - Modern Practice (252 pages)
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Study of XS0601 on Preventing Restenosis 125<br />
restenosis falls into the category of blood-stasis syndrome. Our previous<br />
studies (one of National Eighth Five-Year projects) have shown that<br />
Concentrated Xufu Zhuyu Pill (a classic formula of promoting blood<br />
circulation and removing blood-stasis) had a certain effect on preventing<br />
restenosis (Shi et al., 1995; 1997). XS0601 consists of the main active<br />
position of Ligusticum chuanxiong Hort. and Paeonia lactiflora Pall.<br />
(both are the main ingredients in Concentrated Xufu Zhuyu Pill). In this<br />
study, we observe its clinical effect on preventing restenosis after PCI in<br />
patients with coronary heart disease (CHD), and to explore the probable<br />
mechanism in a porcine coronary injury model.<br />
10.2 Methods<br />
10.2.1 Clinical study<br />
10.2.1.1 Diagnostic criteria<br />
The diagnostic criteria of CHD refers to related criteria on ischemic heart<br />
disease of WHO (Chen, 1995). The diagnostic criteria of blood-stasis<br />
syndrome consults the criteria formulated by the Specialised Committee<br />
of Promoting Blood Circulation and Removing Blood-Stasis in China<br />
Society of Integrated <strong>Chinese</strong> and Western <strong>Medicine</strong> (CJIM, 1987). The<br />
symptoms and signs of blood stasis including angina, purple and dark<br />
tongue or with ecchymosis, purple and dark lip and gingiva, sublingual<br />
varices, uneven pulse or slow pulse with irregular intervals were scored<br />
according to methods introduced by literature (Wang, 1993). Since some<br />
patients in this study were suffering from acute myocardial infarction, the<br />
item of symptom (angina) was replenished “acute myocardial infarction”<br />
and the score was 15.<br />
10.2.1.2 Patient selection and inclusion and exclusion criteria<br />
Patients were enrolled between January 1999 and February 2000 in<br />
The Third Hospital Affiliated to Peking University and Anzhen Hospital<br />
Affiliated to Capital University of Medical Sciences. Patients were eligible<br />
for inclusion if they were 35 to 75 years old, had angina, and/or objective<br />
evidence of myocardial ischemia, or acute myocardial infarction, and there
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