Chinese Medicine - Modern Practice (252 pages)

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Anti-liver Fibrosis with Integrated Traditional Chinese and Western Medicine 7 1 chronic hepatitis B is more suitable for SA-B therapy (Liu et al., 1998d) (Fig. 6.6). 6.3 Multi-Link and Multi-Level Comprehensive Anti-Liver Fibrosis Mechanism of Chinese Herbs The formation and development of liver fibrosis is a rather complicated process, so it is beneficial for us to bring to light the comprehensive advantage of compound recipe of Chinese herbs in inhibiting liver fibrosis from multi-link or multi-level - Chinese herbs are characterised by multi- ingredients. 6.3.1 Inhibiting fibre prolqerating stimulating factor, HSC proliferation, TGFPl and collagen mRNA expression Pharmacodynamics experiment result indicate that FZHY can not only inhibit liver fibrosis formation induced by CC14, but can also enhance reversion of cirrhosis in rats induced by CC14 and dimethylnitrosamine (DMN) (Liu et al., 1997b and c). Lipid peroxidation product MDA is the fibre proliferation stimulating factor which can significantly enhance HSC proliferation, type I collagen mRNA expression and production of collagen. MDA content in liver tissue in rats with chronic liver injury induced by CC14 increases significantly and correlates positively to Hyp content in liver tissue. The recipe can significantly decrease MDA content in liver tissue, indicating that anti-liver fibrosis effect of FZHY is correlated to anti-lipid peroxidation. In vitro experiments on cells isolated from chronic liver injury model after administration and cells that are treated with drug serum suggest that FZHY can significantly inhibit activation and proliferation of HSC, inhibit PDGF-BB stimulated HSC proliferation, inhibit TGF-P1 mRNA and its protein expression of HSC, and inhibit collagen mRNA and protein expression. Further recipe-splitting research reveal that stasis transforming drugs in the recipe has the strongest effect on inhibiting HSC proliferation and activation, right supporting drugs have the best effect on inhibiting type I collagen mRNA and protein expression and cordyceps have the most obvious effect on decreasing TGF-PI mRNA
72 I! Liu et al. B g 20000 -2 a 5 15000 L_ PDGF-BB(-) PDGF-BB(+) Figure 6.7. The effect of drug sera containing Fuzheng Huayu decoction on PDGF-bb stimulated rat HSC proliferation. and protein expression. Experiments on immune injury liver fibrosis in rats induced by bovine albumin indicate that inhibiting the expression of hepatic TGF-P1 and its receptor is the major action mechanism of cordyceps and its effective ingredient-cordyceps polysaccharide against liver fibrosis. The recipe can also inhibit the proliferation of NIW3T3 or fibroblast, decrease intra or extra collagen generation rate and mRNA expression of I, 111, IV type collagen and type I collagen mRNA expression. Compound recipe can enhance reversion of liver fibrosis through regulating interstitial collagenase activity (Hu et al., 1997; Liu et al., 1996a, 1997a, 1998a and d, 1999 and 2002c) (Fig. 6.7). Normal rat's Kupffer cell culture medium (NKcM) has no effect on HSC proliferation, while from the conditioned Kupffer cell medium from acute CC14 injured rats (IKcM) can significantly enhance HSC proliferation and type I collagen secretion, in a time- and dose-dependent manner. FZHY drug serum added to a conditioned Kupffer cell medium (Y-KcM) can significantly inhibit IKcM stimulated HSC proliferation and collagen secretion. Content of PDGF, TGFPl and vascular endothelial growth factor (VEGF) in IKcM increases significantly than that in NKCM and is predominantly the increase of active type TGFP1. Recipe of Chinese herbs can markedly inhibit secretion of PDGF and TGFP in Y-KcM (predominantly inhibit active type TGFP) and also has some effect on inhibiting secretion of VEGF. In vitro subculturing HSC secretes more
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eJLiue5e 7nediciM.e Modern Practice
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Annals of Traditional Chinese Medic
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Contents Contributors Preface to Se
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Contents vii Chapter 15 Clinical an
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Contributors Kelvin Chan School of
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Contributors xi Jian-hua Lin Acupun
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Contributors xiii Jie Wang Xi-yuan
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Preface to Series Does Traditional
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Chapter 1 Risks of Traditional Chin
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Risks of Traditional Chinese Herbal
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Table 1.3. (Continued) Patient desc
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1.13 Discussion Risks of Traditiona
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Page 38 and 39: Risks of Traditional Chinese Herbal
Page 40 and 41: Chapter 2 Research of Acupuncture A
Page 42 and 43: Acupuncture for Heroin-Addicted Pat
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Page 46 and 47: 2.5 Discussion Acupuncture for Hero
Page 48 and 49: Chapter 3 Advances in Research of A
Page 50 and 51: 3.2.1 Angiogenesis and tumours Adva
Page 52 and 53: Advances in Research of Angiogenesi
Page 60 and 61: Chapter 4 The Rationale of Combinat
Page 62 and 63: Rationale of Combination Drug Formu
Page 70 and 71: Chapter 5 Approaches in Treating AI
Page 72 and 73: Approaches in Treating AIDS with Ch
Page 78 and 79: Chapter 6 Anti-liver Fibrosis with
Page 80 and 81: Anti-liver Fibrosis with Integrated
Page 98 and 99: TAnti-liver Fibsosisi with intregra
Page 100 and 101: Chapter 7 Advances in the Treatment
Page 102 and 103: Advances in the Treatment of Lung C
Page 114 and 115: References Advances in the Treatmen
Page 116 and 117: Chapter 8 Direction of TCM Modernis
Page 118 and 119: TCM Modemisation and Quality Contro
Page 120 and 121: TCM Modemisation and Quality Contro
Page 122 and 123: TCM Modernisation and Quality Contr
Page 124 and 125: Chapter 9 A Critical Look at Tradit
Page 126 and 127: A Critical Look at Traditional Medi
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A Critical Look at Traditional Medi
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Chapter 10 Study of XS0601 on Preve
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Study of XS0601 on Preventing Reste
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10.2.3 Statistical analysis Study o
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1.00 - 0.7s - 0.50 - 0.25 - 0.00 -
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Study of XS060I on Preventing Reste
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Chapter 11 Research on Treatment of
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Research on Treatment of AIDS in Ch
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References Research on Treatment of
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Chapter 12 Research and Production
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Research and Production of Dachengq
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Chapter 13 Study on Evacuation of H
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Evacuation of Haematoma and Traditi
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Evacuation of Haemtoma and Traditio
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Chapter 14 The Conceptual Framework
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Conceptual Structure of the ChQOL I
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References Conceptual Structure of
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Chapter 15 Clinical and Experimenta
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Acupuncture Treatment in China 199
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Chapter 16 Approaches in Developing
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Developing an Evidence-Based Curric
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16.5 Conclusion Developing an Evide
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Index acupuncture 23-29, 197-209 ac
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Chinese Medicine - Modern Practice (252 pages)

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