Chinese Medicine - Modern Practice (252 pages)

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Advances in Research of Angiogenesis Effect 35 inflammatory medium; the degradation of vascular endothelial matrix by proteinase; and endothelial cell migration and formation of new blood vessels. Animal experimentations demonstrated that effective inhibition of formation of new blood vessels of the pannus can relieve experimental arthritis - this provides a new approach to the clinical treatment and prevention of rheumatoid arthritis. 3.3 Factors Affecting Angiogenesis Angiogenesis involves wide interaction among cells, soluble factors and extracellular ingredients. Endothelial cells receive the required information of establishing vascular network through four different steps: (1) proteinase causing dissolution of matrix membrane; (2) migration of endothelial cells; (3) proliferation of endothelial cells; and (4) formation of capillary blood vessels. Angiogenesis is influenced and controlled by corrected cytopoiesis factors produced by various kinds of cells, involving cells like mononuclear large phagocytes, lymphocytes mastocytes, tumour cells and endothelial cells. At present, at least 20 kinds of cell-activating factors like vaso- endothelial growth factor (VEGF), acid fibroblast growth factor (aFGF) and alkaline fibroblast growth factor (bFGF) have been found. Through in vitro and animal experiments, ten more effective angiogenesis inhibitors have been found, some of which include angiostatin, endostatin, TNP- 470, etc. 3.4 TCM and Angiogenesis Treatment of angiogenesis diseases with TCM has marked effectiveness. Treatment of this kind of disease through anti-angiogenesis may be due to one of the cellular and molecular mechanisms. This explains why TCM can treat different diseases with the same drugs. Research on the character of TCM drugs in promoting angiogenesis and anti-angiogenesis has become popular, especially studies concerning tumour treatment with anti-angiogenesis drugs. Some anti-angiogenesis components have been separated, like radix ginseng saponin Rg3, tripterine of tripterygium wilfordii, etc.
36 Z. Ding & X. Yuo 3.4.1 Anti-angiogenetic TCM drugs Tripterygium wilfordic has a definite effect on angiogenetic diseases like rheumatoid arthritis, tumour, psoriasis and atherosclerosis. This suggests that tripterygium wilfordic may have anti-angiogenesis effect. Ju Jin Bo et al. used 5 g/ml tripterygium wilfordin to act on the vascular endothelial cells of mice and the result showed that triptergium wilfordin can inhibit the migration and proliferation of vascular endothelial cells, and can also promote the synthesis of extracellular matrix and inhibit the activity of integrin. Therefore, tripterygium wilfordii can control the angiogenesis process through various mechanisms (Zhu et al., 1996a). Ju Jin Bo et al. observed the influence of Fu Tai Bao (a TCM compound agent containing tripterygium wilfordii) on the biological activity of vascular endothelial cells and its therapeutic mechanism on the treatment of psoriasis. The result showed that Fu Tai Bao can inhibit vascular endothelial cell migration into vascular lumen, promote vascular endothelial cells to syn- thesise extra-cellular matrix type IV collagen protein, fibrin-linked protein and matrix membrane-linked protein; regulate the expression of integrin and increase significantly the activity of calcium-dependent adhesion ingredients. All these suggest that Fu Tai Bao can regulate and control the process of angiogenesis through various mechanisms (Zhu et al., 1996b). Gao Yong et al. used the monomer tripterine extracted from tripterygium wilfordii for the study of anti-angiogenesis activity and the result showed that 0.1 mg/ml tripterine can completely inhibit tubule formation ability of human venous endothelial cells stimulated by tumour cell culture medium solution, and 0.01 mg/ml cavity-tripterine can markedly inhibit the growth of endothelial cells (Gao et al., 1998). Chun Xi Jong et al. used different vascular endothelial cell strains to conduct similar experiments and obtained the same result - that tripterine had an anti-angiogenesis effect (Chen et al., 1999). Yan Da Hai et al. used chicken embryo in a screening study of 43 anti-carcinoma formulas and selected 13 drugs which appeared most frequently in anti-angiogenesis investigation, and the result was that rhizoma zedoariae and radix curcumae had an anti-angiogenesis effect (Yan et al., 1998). The experiments performed by Juang Xie Ling demonstrated that semen coicis injection had an anti-angiogenesis effect (Jiang et al., 2000). The research of Shu Jong Ping et al. showed that
Page 2 and 3: eJLiue5e 7nediciM.e Modern Practice
Page 4 and 5: Annals of Traditional Chinese Medic
Page 6 and 7: Contents Contributors Preface to Se
Page 8 and 9: Contents vii Chapter 15 Clinical an
Page 10 and 11: Contributors Kelvin Chan School of
Page 12 and 13: Contributors xi Jian-hua Lin Acupun
Page 14 and 15: Contributors xiii Jie Wang Xi-yuan
Page 16 and 17: Preface to Series Does Traditional
Page 18 and 19: Chapter 1 Risks of Traditional Chin
Page 20 and 21: Risks of Traditional Chinese Herbal
Page 30 and 31: Table 1.3. (Continued) Patient desc
Page 32 and 33: 1.13 Discussion Risks of Traditiona
Page 40 and 41: Chapter 2 Research of Acupuncture A
Page 42 and 43: Acupuncture for Heroin-Addicted Pat
Page 44 and 45: Acupuncture for Heroin-Addicted Pat
Page 46 and 47: 2.5 Discussion Acupuncture for Hero
Page 48 and 49: Chapter 3 Advances in Research of A
Page 50 and 51: 3.2.1 Angiogenesis and tumours Adva
Page 54 and 55: Advances in Research of Angiogenesi
Page 60 and 61: Chapter 4 The Rationale of Combinat
Page 62 and 63: Rationale of Combination Drug Formu
Page 70 and 71: Chapter 5 Approaches in Treating AI
Page 72 and 73: Approaches in Treating AIDS with Ch
Page 78 and 79: Chapter 6 Anti-liver Fibrosis with
Page 80 and 81: Anti-liver Fibrosis with Integrated
Page 98 and 99: TAnti-liver Fibsosisi with intregra
Page 100 and 101: Chapter 7 Advances in the Treatment
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Advances in the Treatment of Lung C
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References Advances in the Treatmen
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Chapter 8 Direction of TCM Modernis
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TCM Modemisation and Quality Contro
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TCM Modemisation and Quality Contro
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TCM Modernisation and Quality Contr
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Chapter 9 A Critical Look at Tradit
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A Critical Look at Traditional Medi
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Chapter 10 Study of XS0601 on Preve
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Study of XS0601 on Preventing Reste
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10.2.3 Statistical analysis Study o
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1.00 - 0.7s - 0.50 - 0.25 - 0.00 -
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Study of XS060I on Preventing Reste
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Chapter 11 Research on Treatment of
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Research on Treatment of AIDS in Ch
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References Research on Treatment of
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Chapter 12 Research and Production
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Research and Production of Dachengq
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Chapter 13 Study on Evacuation of H
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Evacuation of Haematoma and Traditi
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Evacuation of Haemtoma and Traditio
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Chapter 14 The Conceptual Framework
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Conceptual Structure of the ChQOL I
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References Conceptual Structure of
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Chapter 15 Clinical and Experimenta
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Acupuncture Treatment in China 199
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Chapter 16 Approaches in Developing
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Developing an Evidence-Based Curric
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16.5 Conclusion Developing an Evide
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Index acupuncture 23-29, 197-209 ac
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Chinese Medicine - Modern Practice (252 pages)

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