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Principal Investigator/Program Director (Last, First, Middle): Hassoun, Heitham T. 2006-Present American Physiological Society 2006-Present International Society of Endovascular Specialists 2006-Present Society for Vascular Surgery • Member, International Relations Committee (2010-2013) 2007-Present National Kidney Foundation 2007-Present Eastern Society for Vascular Surgery B. Selected Peer-reviewed Publications 1. Safi HJ, Letsou GV, Iliopoulos DC, Subramaniam MH, Miller CT, Hassoun, HT, Asimacopoulos PJ, and Baldwin JC: Impact of retrograde cerebral perfusion on ascending aortic and arch aneurysm repair. Ann Thoracic Surgery, 63:1601-1607, 1997. 2. Toursarkisian B, Hassoun HT, Hagino RT, Godsey J, and Sykes MT: Efficacy of infrainguinal bypass for limb salvage in young diabetic patients. J Diabetes Complications, 14:255-258, 2000. 3. Hassoun HT, Kone BC, Mercer DW, Moody FG, Weisbrodt NW, Moore FA: Postinjury multiple organ failure: The role of the gut. Shock, 15:1-10, 2001. 4. Hassoun HT, Weisbrodt NW, Mercer DW, Kozar RA, Moody FG, Moore FA: Inducible nitric oxide synthase mediates gut ischemia/reperfusion induced ileus only after severe insults. J. Surg. Res. 97:150-154, 2001. 5. Hassoun HT, Moore FA, Kozar RA, Weisbrodt NW, Kone BC: α-Melanocyte stimulating hormone protects against mesenteric ischemia-reperfusion injury. Amer. J. Physiol., 282:G1059-G1068, 2002. 6. Kozar RA, Hu S, Hassoun HT, DeSoignie R, Moore FA: Specific intraluminal nutrients alter mucosal blood flow during gut ischemia/reperfusion. JPEN, 26:226-229, 2002. 7. Safi HJ, Miller CC, Estrera AL, Huynh TT, Porat EE, Hassoun HT, Buja LM: Chronic aortic dissection not a risk factor for neurologic deficit in thoracoabdominal aortic aneurysm repair. Eur J Vasc Endovasc Surg. 23:244-250, 2002. 8. Hassoun HT, Kozar RA, Kone BC, Safi HJ, Moore FA: Intraischemic hypothermia differentially modulates oxidative stress proteins during mesenteric ischemia/reperfusion. Surgery. 132:369-376, 2002. 9. Kozar RA, Schultz SG, Hassoun HT, DeSoignie R, Weisbrodt NW, Haber MM, Moore FA: The type of sodiumcoupled solute modulates small bowel mucosal injury, transport function and ATP after ischemia/reperfusion injury in rats. Gastroenterology. 123:810-816, 2002. 10. Safi HJ, Miller CC, Huynh TT, Estrera AL, Porat EE, Win nerkvist AN, Allen BS, Hassoun HT, Moore FA: Distal aortic perfusion and cerebrospinal fluid drainage for thoracoabdominal and descending thoracic aortic repair: ten years of organ protection. Ann Surg. 238:372-381, 2003. 11. Attuwaybi BO, Hassoun HT, Zou L, Kozar RA, Kone BC, Weisbrodt NW, Moore FA: Hypothermia protects against gut ischemia/reperfusion induced impaired intestinal transit by inducing heme oxygenase-1. J Surg Res. 115:48-55, 2003. 12. Hassoun HT, Fischer UM, Attuwaybi BO, Moore FA, Safi HJ, Allen SJ, Cox CS: Regional hypothermia reduces mucosal NF-κB and PMN priming via gut lymph during canine mesenteric ischemia/reperfusion. J Surg Res. 115:121-126, 2003. 13. Kozar RA, Holcomb JB, Hassoun HT, Macaitis JM, DeSoignie R, Moore FA: Superior mesenteric artery occlusion models shock-induced gut ischemia-reperfusion. J Surg Res. 116:145-150, 2004. 14. Hassoun HT, Miller CC, Huynh TT, Estrera AL, Smith JJ, Safi HJ: Cold visceral perfusion improves early survival in patients with acute renal failure after thoracoabdominal aortic aneurysm repair. J Vasc Surg. 39:506-512, 2004. 15. Attuwaybi BO, Kozar RA, Moore-Olufemi SD, Sato N, Hassoun HT, Weisbrodt NW, Moore FA: Heme oxygenase- 1 induction by hemin protects against gut ischemia/reperfusion injury. J Surg Res. 118:53-57, 2004. 16. Safi HJ, Huynh TT, Hassoun HT, Miller CC, Estrera AL: Preventing renal failure in thoracoabdominal aortic aneurysm repair. Pers Vasc Surg Endovasc Ther 16:3-13, 2004. 17. Moore-Olufemi SD, Kozar RA, Moore FA, Sato N, Hassoun HT, Cox CS Jr, Kone BC: Ischemic preconditioning protects against gut dysfunction and mucosal injury after ischemia/reperfusion injury. Shock 23:258-63, 2005. 18. Huynh TT, Miller CC, Estrera AL, Mohamed SG, Hassoun HT, Sheinbaum R, Porat EE, Safi HJ: Correlations of cerebrospinal fluid pressure with hemodynamic parameters during thoracoabdominal aortic aneurysm repair. Ann Vasc Surg 19:1-6, 2005. 19. Hassoun HT, Dake MD, Svensson LG, Greenberg RK, Cambria RP, Moore RD, Matsumura JS: Multi-institutional pivotal trial of the zenith tx2 thoracic aortic stent graft for treatment of descending thoracic aortic aneurysms: clinical study design. Pers Vasc Surg Endovasc Ther 17 (3): 255-64, 2005. 20. Hassoun HT, Mitchell RS, Makaroun MS, Whiting AJ, Cardeira KR, Matsumura JS: Aortic neck morphology after endovascular repair of descending thoracic aneurysms. J Vasc Surg, 43:26-31, 2006. 21. Hassoun HT, Matsumura JS: The Cook TX2 thoracic stent graft; preliminary experience and trial design. Semin in Vasc Surg 19:32-39, 2006.
Principal Investigator/Program Director (Last, First, Middle): Hassoun, Heitham T. 22. Peterson BG, Resnick SA, Morasch MD, Hassoun HT, Eskandari MK: Aortic arch vessel stenting: a single-center experience using cerebral protection. Arch of Surgery 141:560-64, 2006. 23. Schena S, Hassoun HT, Owens CA, Kibbe MR: Posttraumatic superficial femoral artery pseudoaneurysm associated with an arteriovenous fistula. J Am Coll Surg 203:250-1, 2006. 24. Hassoun HT, Grigoryev DG, Lie ML, Liu M, Cheadle C, Tuder RT, Rabb H. Ischemic acute kidney injury induces a distant organ functional and genomic response distinguishable from bilateral nephrectomy. Am J Physiol Renal Physiol 293:F30-40, 2007. 25. Grigoryev DG, Liu M, Hassoun HT, Cheadle C, Barnes KC, Rabb H: The local and systemic inflammatory transcriptome after acute kidney injury. J Am Soc Nephrol 19(3):547-58, 2008. 26. Hoag JB, Liu M, Easley RB, Hassoun H, Haas M, Rabb H, Simon BA: Effects of acid aspiration induced acute lung injury on kidney function. Am J Physiol Renal Physiol, 294(4):F900-8, 2008. 27. Dodd-o J, Hristopoulos M, Scharfstein D, Brower R, Hassoun P, King L, Becker P, Liu M, Wang W, Hassoun HT, Rabb H: Interactive effects of mechanical ventilation and kidney health on lung function in an in vivo mouse model. Am J Physiol: Lung Cell Mol Physiol,296(1):L3-L11, 2009. 28. Ascon M, Ascon DB, Liu M, Cheadle C, Sarkar C, Racusen L, Hassoun HT, Rabb H: Renal ischemia-reperfusion leads to long term infiltration of activated and effector-memory T lymphocytes. Kidney Int, 75(5):526-35, 2009. 29. De Leon RA, Hassoun HT, Black JH, Roseborough GS, Perler BA, Call D, Busse C, Freischlag JA: Multiple treatment algorithms now needed for successful outcomes in effort thrombosis. Surgery, 145:500-07, 2009. 30. Ko GJ, Rabb H, Hassoun HT: Kidney-lung crosstalk in the critically ill patient. Blood Purif, 28:75-83, 2009. 31. Hassoun HT, Lie ML, Grigoryev DN, Liu M, Tuder RM, Rabb H: Pulmonary apoptosis mediates distant organ lung dysfunction during experimental ischemic acute kidney injury. Am J Physiol Renal Physiol, 297(1):F125-137, 2009. 32. Li X, Hassoun HT, Santora R, Rabb H: Organ crosstalk: The role of the kidney. Current Opinion in Critical Care, 15(6):481-7, 2009. 33. Guzzo JL, Hassoun HT: Renal vein stenting for nutcracker syndrome. Endovascular Today, 9(4):25-28, 2010. 34. Gasparyan AY, Mohammad-Hasani MR, Hassoun H, Darban H. Recent advances in cardiovascular medicine: The tenth Iranian congress on cardiovascular update. Arch Iran Med 12(2):213-16, 2009. 35. Nadler EP, Nwomeh BC, Frederick WA, Hassoun HT, Kingham TP, Krishnaswami S, London JA, Pitt SC, Riviello R, Rogers SO. Academic needs in developing countries: a survey of the West African college of surgeons. J Surg Res 160(1):14-17, 2010. 36. Hassoun HT, Malas MB, Freischlag JA: Secondary stroke prevention in the era of carotid stenting: update on the recent trials. Arch Surg, 145(10):928-35, 2010. 37. Santora RJ, Lie, ML, Grigoryev DG, Nasir O, Moore, FA, Hassoun HT: Therapeutic distant organ effects of regional hypothermia during mesenteric ischemia-reperfusion injury. J Vasc Surg, 52(4):1003-14. 38. Laura E. White MD, Rahul Chaudhary MD, Laura J. Moore MD, Frederick A. Moore MD, and Heitham T. Hassoun MD. Surgical sepsis and organ crosstalk: the role of the kidney. J Surg Res [In press]. Book Chapters, Invited Commentary & Review Articles 1. Safi HJ, Miller CT, Iliopoulos DC, Hassoun HT: Thoracic aortic aneurysm in the USA. Chapter in Recent Advances in Cardiovascular Diseases in the Elderly. Churchill Livingstone Publishers, Osaka, pp. 95-135, 1996. 2. Hassoun HT, Moore FA: The role of gut hypoperfusion in multiple organ failure. Chapter in Current Techniques in Modern Vascular Surgery, JST Yao, WH Pearce, eds., McGraw-Hill Publishers, pp. 419-430, 2000. 3. Hassoun HT, Moore FA: Electrolyte disorders. Chapter in Current Surgical Therapy, 7 th Ed. JL Cameron, Ed., Mosby, Inc., pp. 1315-1321, 2001. 4. Hassoun HT, Moore FA: Pericardial tamponade. Chapter in: The Practice of General Surgery, KI Bland, ed., W.B. Saunders Co., pp. 225-228, 2002. 5. Hassoun HT, Huynh TT, Safi HJ: Regarding “Cold viseceral perfusion improves early survival in patients with acute renal failure after thoracoabdominal aortic aneurysm repair”. Invited Commentary in J Vasc Surg 40(1):205- 206, 2004. 6. Kibbe MR, Hassoun HT: 16 Acute mesenteric ischemia. 5 Vascular system. Chapter in ACS Surgery: Principles & Practice, Souba WW, Fink MP, Jurkovich GJ, et al, Eds. WebMD Inc., pp. 1-11, 2005. 7. Hassoun HT, Chiou AC, Biggs KL, Matsumura JS: Endovascular graft for thoracic aortic aneurysms. Chapter in Trends in Vascular Surgery 2005, WH Pearce, JS Matsumura, JST Yao, eds., Greenwood Academic, pp. 329- 342, 2005. 8. Estrera AL, Hassoun HT, Huynh TTT, Miller CC, Azizzadeh A, Porat EE, Safi HJ: Open surgical treatment of thoracoabdominal aortic aneurysms. Chapter in Trends in Vascular Surgery 2005, WH Pearce, JS Matsumura, JST Yao, eds., Greenwood Academic, pp. 343-357, 2005.
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