BIOGRAPHICAL SKETCH - Methodist Hospital

BIOGRAPHICAL SKETCH
Provide the following information for the key personnel and other significant contributors in the order listed on Form Page 2.
Follow this format for each person. DO NOT EXCEED FOUR PAGES.
NAME
Hassoun, Heitham Talal
eRA COMMONS USER NAME
POSITION TITLE
Associate Professor of Surgery
Director, Basic & Translational Science Research
EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, and include postdoctoral training.)
INSTITUTION AND LOCATION
DEGREE
(if applicable)
YEAR(s) FIELD OF STUDY
THE JOHNS HOPKINS UNIVERSITY, BALTIMORE, MD B.A. 1993 NATURAL SCIENCES
BAYLOR COLLEGE OF MEDICINE, HOUSTON, TX M.D. 1997 MEDICINE
A. Positions and Honors
Professional Positions
1997-1999 Intern/Resident, General Surgery, UTHSC - San Antonio, TX
1999-2001 Trauma Research Center Fellowship (T32-GM08792) - UT-Houston Medical School, Houston, TX
2001-2004 Resident, General Surgery, UT-Houston Medical School, Houston, TX
2004-2005 Instructor and Fellow, Vascular Surgery, Northwestern University, Chicago, IL
2005-2009 Assistant Professor of Surgery, Johns Hopkins University, Baltimore, MD
2009- Associate Professor of Cardiovascular Surgery, Weill Cornell Medical College (Pending)
Honors and Awards
2000 Young Investigator Award -- American Motility Society
2000 ACS Committee on Trauma Paper Competition -- Region VI Finalist Basic Science
2001 ACS Committee on Trauma Paper Competition -- Region VI Winner Basic Science
2001 ACS South Texas Chapter Resident Basic Science Competition -- First Place, Resident Basic Science
Competition
2002 ACS South Texas Chapter Resident Basic Science Competition -- First Place Resident Basic Science
Competition
2006 Johns Hopkins Department of Surgery Pilot Award - “Regional Therapeutic Hypothermia for Mesenteric
Ischemia/Reperfusion Injury”
2006 NIH 4th Symposium on Functional Genomics of Critical Illness and Injury - Surviving Stress: Organ Systems
to Molecules - Bethesda, MD - Nov. 13-14, 2006 - Symposium Award for Top Abstract
2008 Arab Health Award – Surgery – Advances in Cardiovascular Interventional Therapy at Tawam Hospital –
Dubai, UAE – Jan 30, 2008
2008 American Vascular Association/American College of Surgeons - Lifeline K08 Award
Other Experience and Professional Memberships
Reviewer: Journal of Surgical Research, BCM Genomics, Surgery, Digestive Diseases & Sciences
Key Reviewer: Journal of Vascular surgery
Member of Editorial Board: Journal of Surgical Research
2002-Present Shock Society
2003-Present Association for Academic Surgery
• Member, Development Committee (2007-2008)
• Member, Global Affairs Committee (2008-2010)
2006-Present American College of Surgeons, Fellow
2006-Present American Heart Association
• Council on Cardiovascular Radiology & Intervention
• Council on Functional Genomics & Translational Biology

Principal Investigator/Program Director (Last, First, Middle): Hassoun, Heitham T.
2006-Present American Physiological Society
2006-Present International Society of Endovascular Specialists
2006-Present Society for Vascular Surgery
• Member, International Relations Committee (2010-2013)
2007-Present National Kidney Foundation
2007-Present Eastern Society for Vascular Surgery
B. Selected Peer-reviewed Publications
1. Safi HJ, Letsou GV, Iliopoulos DC, Subramaniam MH, Miller CT, Hassoun, HT, Asimacopoulos PJ, and Baldwin
JC: Impact of retrograde cerebral perfusion on ascending aortic and arch aneurysm repair. Ann Thoracic Surgery,
63:1601-1607, 1997.
2. Toursarkisian B, Hassoun HT, Hagino RT, Godsey J, and Sykes MT: Efficacy of infrainguinal bypass for limb
salvage in young diabetic patients. J Diabetes Complications, 14:255-258, 2000.
3. Hassoun HT, Kone BC, Mercer DW, Moody FG, Weisbrodt NW, Moore FA: Postinjury multiple organ failure: The
role of the gut. Shock, 15:1-10, 2001.
4. Hassoun HT, Weisbrodt NW, Mercer DW, Kozar RA, Moody FG, Moore FA: Inducible nitric oxide synthase
mediates gut ischemia/reperfusion induced ileus only after severe insults. J. Surg. Res. 97:150-154, 2001.
5. Hassoun HT, Moore FA, Kozar RA, Weisbrodt NW, Kone BC: α-Melanocyte stimulating hormone protects against
mesenteric ischemia-reperfusion injury. Amer. J. Physiol., 282:G1059-G1068, 2002.
6. Kozar RA, Hu S, Hassoun HT, DeSoignie R, Moore FA: Specific intraluminal nutrients alter mucosal blood flow
during gut ischemia/reperfusion. JPEN, 26:226-229, 2002.
7. Safi HJ, Miller CC, Estrera AL, Huynh TT, Porat EE, Hassoun HT, Buja LM: Chronic aortic dissection not a risk
factor for neurologic deficit in thoracoabdominal aortic aneurysm repair. Eur J Vasc Endovasc Surg. 23:244-250,
2002.
8. Hassoun HT, Kozar RA, Kone BC, Safi HJ, Moore FA: Intraischemic hypothermia differentially modulates
oxidative stress proteins during mesenteric ischemia/reperfusion. Surgery. 132:369-376, 2002.
9. Kozar RA, Schultz SG, Hassoun HT, DeSoignie R, Weisbrodt NW, Haber MM, Moore FA: The type of sodiumcoupled
solute modulates small bowel mucosal injury, transport function and ATP after ischemia/reperfusion
injury in rats. Gastroenterology. 123:810-816, 2002.
10. Safi HJ, Miller CC, Huynh TT, Estrera AL, Porat EE, Win nerkvist AN, Allen BS, Hassoun HT, Moore FA: Distal
aortic perfusion and cerebrospinal fluid drainage for thoracoabdominal and descending thoracic aortic repair: ten
years of organ protection. Ann Surg. 238:372-381, 2003.
11. Attuwaybi BO, Hassoun HT, Zou L, Kozar RA, Kone BC, Weisbrodt NW, Moore FA: Hypothermia protects
against gut ischemia/reperfusion induced impaired intestinal transit by inducing heme oxygenase-1. J Surg Res.
115:48-55, 2003.
12. Hassoun HT, Fischer UM, Attuwaybi BO, Moore FA, Safi HJ, Allen SJ, Cox CS: Regional hypothermia reduces
mucosal NF-κB and PMN priming via gut lymph during canine mesenteric ischemia/reperfusion. J Surg Res.
115:121-126, 2003.
13. Kozar RA, Holcomb JB, Hassoun HT, Macaitis JM, DeSoignie R, Moore FA: Superior mesenteric artery occlusion
models shock-induced gut ischemia-reperfusion. J Surg Res. 116:145-150, 2004.
14. Hassoun HT, Miller CC, Huynh TT, Estrera AL, Smith JJ, Safi HJ: Cold visceral perfusion improves early survival
in patients with acute renal failure after thoracoabdominal aortic aneurysm repair. J Vasc Surg. 39:506-512, 2004.
15. Attuwaybi BO, Kozar RA, Moore-Olufemi SD, Sato N, Hassoun HT, Weisbrodt NW, Moore FA: Heme oxygenase-
1 induction by hemin protects against gut ischemia/reperfusion injury. J Surg Res. 118:53-57, 2004.
16. Safi HJ, Huynh TT, Hassoun HT, Miller CC, Estrera AL: Preventing renal failure in thoracoabdominal aortic
aneurysm repair. Pers Vasc Surg Endovasc Ther 16:3-13, 2004.
17. Moore-Olufemi SD, Kozar RA, Moore FA, Sato N, Hassoun HT, Cox CS Jr, Kone BC: Ischemic preconditioning
protects against gut dysfunction and mucosal injury after ischemia/reperfusion injury. Shock 23:258-63, 2005.
18. Huynh TT, Miller CC, Estrera AL, Mohamed SG, Hassoun HT, Sheinbaum R, Porat EE, Safi HJ: Correlations of
cerebrospinal fluid pressure with hemodynamic parameters during thoracoabdominal aortic aneurysm repair. Ann
Vasc Surg 19:1-6, 2005.
19. Hassoun HT, Dake MD, Svensson LG, Greenberg RK, Cambria RP, Moore RD, Matsumura JS: Multi-institutional
pivotal trial of the zenith tx2 thoracic aortic stent graft for treatment of descending thoracic aortic aneurysms:
clinical study design. Pers Vasc Surg Endovasc Ther 17 (3): 255-64, 2005.
20. Hassoun HT, Mitchell RS, Makaroun MS, Whiting AJ, Cardeira KR, Matsumura JS: Aortic neck morphology after
endovascular repair of descending thoracic aneurysms. J Vasc Surg, 43:26-31, 2006.
21. Hassoun HT, Matsumura JS: The Cook TX2 thoracic stent graft; preliminary experience and trial design. Semin
in Vasc Surg 19:32-39, 2006.

Principal Investigator/Program Director (Last, First, Middle): Hassoun, Heitham T.
22. Peterson BG, Resnick SA, Morasch MD, Hassoun HT, Eskandari MK: Aortic arch vessel stenting: a single-center
experience using cerebral protection. Arch of Surgery 141:560-64, 2006.
23. Schena S, Hassoun HT, Owens CA, Kibbe MR: Posttraumatic superficial femoral artery pseudoaneurysm
associated with an arteriovenous fistula. J Am Coll Surg 203:250-1, 2006.
24. Hassoun HT, Grigoryev DG, Lie ML, Liu M, Cheadle C, Tuder RT, Rabb H. Ischemic acute kidney injury induces
a distant organ functional and genomic response distinguishable from bilateral nephrectomy. Am J Physiol Renal
Physiol 293:F30-40, 2007.
25. Grigoryev DG, Liu M, Hassoun HT, Cheadle C, Barnes KC, Rabb H: The local and systemic inflammatory
transcriptome after acute kidney injury. J Am Soc Nephrol 19(3):547-58, 2008.
26. Hoag JB, Liu M, Easley RB, Hassoun H, Haas M, Rabb H, Simon BA: Effects of acid aspiration induced acute
lung injury on kidney function. Am J Physiol Renal Physiol, 294(4):F900-8, 2008.
27. Dodd-o J, Hristopoulos M, Scharfstein D, Brower R, Hassoun P, King L, Becker P, Liu M, Wang W, Hassoun HT,
Rabb H: Interactive effects of mechanical ventilation and kidney health on lung function in an in vivo mouse
model. Am J Physiol: Lung Cell Mol Physiol,296(1):L3-L11, 2009.
28. Ascon M, Ascon DB, Liu M, Cheadle C, Sarkar C, Racusen L, Hassoun HT, Rabb H: Renal ischemia-reperfusion
leads to long term infiltration of activated and effector-memory T lymphocytes. Kidney Int, 75(5):526-35, 2009.
29. De Leon RA, Hassoun HT, Black JH, Roseborough GS, Perler BA, Call D, Busse C, Freischlag JA: Multiple
treatment algorithms now needed for successful outcomes in effort thrombosis. Surgery, 145:500-07, 2009.
30. Ko GJ, Rabb H, Hassoun HT: Kidney-lung crosstalk in the critically ill patient. Blood Purif, 28:75-83, 2009.
31. Hassoun HT, Lie ML, Grigoryev DN, Liu M, Tuder RM, Rabb H: Pulmonary apoptosis mediates distant organ
lung dysfunction during experimental ischemic acute kidney injury. Am J Physiol Renal Physiol, 297(1):F125-137,
2009.
32. Li X, Hassoun HT, Santora R, Rabb H: Organ crosstalk: The role of the kidney. Current Opinion in Critical
Care, 15(6):481-7, 2009.
33. Guzzo JL, Hassoun HT: Renal vein stenting for nutcracker syndrome. Endovascular Today, 9(4):25-28, 2010.
34. Gasparyan AY, Mohammad-Hasani MR, Hassoun H, Darban H. Recent advances in cardiovascular medicine:
The tenth Iranian congress on cardiovascular update. Arch Iran Med 12(2):213-16, 2009.
35. Nadler EP, Nwomeh BC, Frederick WA, Hassoun HT, Kingham TP, Krishnaswami S, London JA, Pitt SC, Riviello
R, Rogers SO. Academic needs in developing countries: a survey of the West African college of surgeons. J Surg
Res 160(1):14-17, 2010.
36. Hassoun HT, Malas MB, Freischlag JA: Secondary stroke prevention in the era of carotid stenting: update on the
recent trials. Arch Surg, 145(10):928-35, 2010.
37. Santora RJ, Lie, ML, Grigoryev DG, Nasir O, Moore, FA, Hassoun HT: Therapeutic distant organ effects of
regional hypothermia during mesenteric ischemia-reperfusion injury. J Vasc Surg, 52(4):1003-14.
38. Laura E. White MD, Rahul Chaudhary MD, Laura J. Moore MD, Frederick A. Moore MD, and Heitham T.
Hassoun MD. Surgical sepsis and organ crosstalk: the role of the kidney. J Surg Res [In press].
Book Chapters, Invited Commentary & Review Articles
1. Safi HJ, Miller CT, Iliopoulos DC, Hassoun HT: Thoracic aortic aneurysm in the USA. Chapter in Recent
Advances in Cardiovascular Diseases in the Elderly. Churchill Livingstone Publishers, Osaka, pp. 95-135,
1996.
2. Hassoun HT, Moore FA: The role of gut hypoperfusion in multiple organ failure. Chapter in Current Techniques
in Modern Vascular Surgery, JST Yao, WH Pearce, eds., McGraw-Hill Publishers, pp. 419-430, 2000.
3. Hassoun HT, Moore FA: Electrolyte disorders. Chapter in Current Surgical Therapy, 7 th Ed. JL Cameron, Ed.,
Mosby, Inc., pp. 1315-1321, 2001.
4. Hassoun HT, Moore FA: Pericardial tamponade. Chapter in: The Practice of General Surgery, KI Bland, ed.,
W.B. Saunders Co., pp. 225-228, 2002.
5. Hassoun HT, Huynh TT, Safi HJ: Regarding “Cold viseceral perfusion improves early survival in patients with
acute renal failure after thoracoabdominal aortic aneurysm repair”. Invited Commentary in J Vasc Surg 40(1):205-
206, 2004.
6. Kibbe MR, Hassoun HT: 16 Acute mesenteric ischemia. 5 Vascular system. Chapter in ACS Surgery:
Principles & Practice, Souba WW, Fink MP, Jurkovich GJ, et al, Eds. WebMD Inc., pp. 1-11, 2005.
7. Hassoun HT, Chiou AC, Biggs KL, Matsumura JS: Endovascular graft for thoracic aortic aneurysms. Chapter in
Trends in Vascular Surgery 2005, WH Pearce, JS Matsumura, JST Yao, eds., Greenwood Academic, pp. 329-
342, 2005.
8. Estrera AL, Hassoun HT, Huynh TTT, Miller CC, Azizzadeh A, Porat EE, Safi HJ: Open surgical treatment of
thoracoabdominal aortic aneurysms. Chapter in Trends in Vascular Surgery 2005, WH Pearce, JS Matsumura,
JST Yao, eds., Greenwood Academic, pp. 343-357, 2005.

Principal Investigator/Program Director (Last, First, Middle): Hassoun, Heitham T.
9. Hassoun HT: Comprehensive vascular and endovascular surgery. Book review in Shock 23(2):194-195, 2005.
10. Hassoun HT: Acute mesenteric ischemia. Chapter in Current Surgical Therapy, 9 th Ed. JL Cameron, Ed.,
Mosby, Inc., pp. 884-889, 2008.
11. Jain A, Hassoun HT, Freischlag JA: Primary vascular tumors. Chapter in Principles and Practice of Surgical
Oncology, 2 nd Ed. H Silberman & AW Silberman, Eds., Lippincott Williams & Wilkins, pp 899-906, 2009.
12. Hassoun HT: Gore excluder AAA endoprosthesis in tortuous anatomy. Gore Peripheral Vision, 2:6, 2009.
13. Kibbe MR, Hassoun HT: Acute mesenteric ischemia. 6. Vascular System. Chapter in ACS Surgery: Principles
& Practice, 6 th Ed, Souba WW, Fink MP, Jurkovich GJ, et al, Eds. WebMD Inc., New York, NY, pp. 1016-1026,
2010.
14. Hassoun HT: Paradigm shift in the treatment of blunt aortic injury: a good thing. Arch Surg, 145(10):1011-1012,
2010.
15. White LE, Chaudhary R, Moore LJ, Moore FA, Hassoun HT. Surgical sepsis and organ crosstalk: the role of the
kidney. J Surg Res. 2011 May 15;167(2):306-15. Epub 2010 Dec 30. Review
16. Santora RJ, Hassoun HT. HB-EGF and Mesenteric Ischemia. J Surg Res. 2011 Jul;169(1):19-20.
17. Santora RJ, Hassoun HT: Gangrene of the foot. Chapter in Current Surgical Therapy, 10 th Ed., JL Cameron,
Ed., Mosby, Inc., pp. 845-50
19. Santora RJ, Hassoun HT: HB-EGF and mesenteric ischemia. J Surg Res. 2011 Jul;169(1):19-20.
C. Research Grants and Contracts
NIH Funding
NIH (NHLBI K08 HL089181A) Hassoun (PI) 7/1/2008-6/30/2013
Kidney-Lung interactions during ischemia-reperfusion injury
Role: PI
NIH (Johns Hopkins Hospital) Ratchford (PI) 5/2008-Present
CLEVER (Claudication: Exercise Vs. Endoluminal Revascularization) Trial
Role: Co-Investigator
NIH (Johns Hopkins Hospital) Malas (PI) Completed (2008)
CREST (Carotid Revascularization Endarterectomy vs. Stenting) Trial”
Role: Co-Investigator
Foundation/Corporate Funding
TriVascular, Inc (The Methodist Hospital) Hassoun (PI) 2010 - present
A Pivotal Clinical Study to Evaluate the Safety and Effectiveness of the TriVascular AAA Stent
Graft System
Role: PI
American Vascular Association/American College of Surgeons Jointly Sponsored Mentored Clinical Scientist
Award Hassoun (PI) 7/1/2008-6/30/2013
Kidney-Lung interactions during ischemia-reperfusion injury
Role: PI
Abbott Vascular (Johns Hopkins Hospital) Malas (PI) 2007-2009
Carotid Stenting for High Surgical Risk Patients; Evaluating Outcomes through the Collection of Clinical Evidence
(CHOICE)
Role: Co-Investigator
Lombard Medical (Johns Hopkins Hospital) Malas (PI) 2007-2008
Prospective aneurysm trial: High angle Aorfix bifurcated stent graft (Pythagoras) trial
Role: Co-Investigator
Sponsor: Abbott Vascular (Johns Hopkins Hospital) Malas (PI) Completed (2008)
Carotid ACCULINK/ACCUNET Post Approval Trial to Uncover Rare Events (CAPTURE 2)
Role: Co-Investigator
Johns Hopkins University Hassoun (PI) Completed (2007)
Therapeutic regional hypothermia for mesenteric ischemia/reperfusion injury
Role: PI