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Dr Gnant - ESMO Oral Presentation 08

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ZOL Significantly Improves DFS Compared<br />

With Endocrine Therapy Alone<br />

Disease-free survival, %<br />

100<br />

90<br />

80<br />

70<br />

60<br />

50<br />

40<br />

30<br />

20<br />

10<br />

0<br />

No. of Hazard ratio (95% CI)<br />

events vs No ZOL P value<br />

ZOL 54 0.643 (0.46, 0.91) .012<br />

No ZOL 83<br />

0 12 24 36 48 60 72 84<br />

Time since randomization, months<br />

No. at risk<br />

No ZOL 904 832 713 537 407 241 145 47<br />

ZOL 899 846 730 555 414 257 123 54<br />

Median follow-up = 48 months.<br />

DFS = Disease-free survival; CI = Confidence interval; ZOL = Zoledronic acid.<br />

Update of <strong>Gnant</strong> M, et al. Presented at: ASCO 20<strong>08</strong>. Chicago, IL. Abstract LBA4.<br />

10

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