Dr Gnant - ESMO Oral Presentation 08
Dr Gnant - ESMO Oral Presentation 08
Dr Gnant - ESMO Oral Presentation 08
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Zoledronic Acid Can Inhibit the Process of<br />
Metastasis at Several Key Steps<br />
Primary tumor<br />
Synergy with<br />
anticancer drugs<br />
Inhibits<br />
angiogenesis<br />
Angiogenesis<br />
Metastases Micrometastases<br />
Adhesion &<br />
extravasation<br />
Adapted from Mundy GR, et al. Nature Reviews Cancer. 2002;2:584-593.<br />
Direct antitumor effect Indirect antitumor effect<br />
Induces<br />
tumor cell<br />
apoptosis<br />
Stimulates immune<br />
surveillance<br />
Invasion<br />
Decreases<br />
matrix invasion<br />
Decreases<br />
adhesion to bone<br />
Arrest in distant<br />
capillary<br />
4
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