Anti-inflammatoires non-stéroïdiens (AINS) et paracétamol:

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GI mortality associated with typical NSAIDs vs other causes in US Cigarette smoking Cancer NSAID use Motor vehicle accident Home accident Airplane crash (frequent flyer) Annual risk of death (%) 0.0 0.1 0.2 0.3 0.4 Fries et al. Am J Med. 1991;91:213–222; Wilson, Crouch. Science. 1987;236:267–270. 2009-2010 AINS et paracetamol 32
*NSAIDs - Relative Risk of GI Complications Drug Relative Risk (95% C.I.) None 1 Ibuprofen 2.1 (0.6 - 7.1) Diclofenac 2.7 (1.5 - 4.8) Other NSAID (n=16) 2.9 (1.4 - 6.3) Ketoprofen 3.2 (0.9 - 11.9) Naproxen 4.3 (1.6 - 11.2) Tenoxicam 4.3 (1.9 - 9.7) Nimesulide 4.4 (2.5 - 7.7) Indomethacin 5.5 (1.6 - 18.9) Piroxicam 9.5 (6.5 - 13.8) Ketorolac 24.7 (9.6 - 63.5) * Rodriguez et al, Arch Intern Med, 1998, 158, 33-39 2009-2010 AINS et paracetamol 33
Page 1 and 2: Anti-inflammatoires non-stéroïdie
Page 3 and 4: • • • • • • • • •
Page 5 and 6: • • • Douleur ... propagation
Page 7 and 8: • • • Types de sensations dou
Page 9 and 10: Mécanismes de transduction des voi
Page 11 and 12: Contrôle du passage l'information
Page 13 and 14: • • Causes de l'inflammation Fa
Page 15 and 16: COX Activity 1600 1200 800 400 0 Ef
Page 17 and 18: O O O O Métabolisme OOH OH de l'ac
Page 19 and 20: • • • • Découverte des ant
Page 21 and 22: Filling up the enzyme with salicyli
Page 23 and 24: Mapping of the cyclooxygenase COX-1
Page 25 and 26: • • • • • • Classes d'A
Page 27 and 28: Upper - GI Renal Adverse Effects of
Page 29 and 30: X Support Renal and Platelet Functi
Page 31: • • • • • NSAID Ulcers an
Page 35 and 36: COX-2: a new anti-inflammatory drug
Page 37 and 38: heme Kurumbail RG et al. Nature 199
Page 39 and 40: H3 CO hydrophilic group Pharmacoche
Page 41 and 42: Importance of the Ile Val change i
Page 43 and 44: Cox-1 vs flurbiprofene Picot et al.
Page 45 and 46: Clinical efficacy ? 2009-2010 AINS
Page 47 and 48: Celecoxib vs Diclofenac plus omepra
Page 49 and 50: Localization of COX-1 and COX-2 in
Page 51 and 52: The hypertension story starting in
Page 53 and 54: • F • F F Y-a-t-il un avenir po
Page 55 and 56: Making an irreversible linkage by a
Page 57 and 58: AINS et principales interactions m
Page 59 and 60: Metabolisme O O > 5-10 g hépatique
Page 61 and 62: Le paracétamol "en notice" … Pra
Page 63 and 64: • • • Principaux usages clini
Page 65: • • • • • Autres médicam

Anti-inflammatoires non-stéroïdiens (AINS) et paracétamol:

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