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Anti-inflammatoires non-stéroïdiens (AINS) et paracétamol:

Anti-inflammatoires non-stéroïdiens (AINS) et paracétamol:

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Making an irreversible linkage by ac<strong>et</strong>ylation with<br />

ac<strong>et</strong>ylsalicylic acid<br />

heme<br />

Hydrophobic<br />

channel<br />

ac<strong>et</strong>ylation<br />

of the channel<br />

tyrosine 385<br />

O<br />

C<br />

C=0<br />

CH 3<br />

2009-2010 <strong>AINS</strong> <strong>et</strong> parac<strong>et</strong>amol 55<br />

- O<br />

O<br />

+<br />

Ac<strong>et</strong>ylation of the<br />

serin 530<br />

Arginine 120<br />

- O<br />

O<br />

C<br />

O<br />

C=0<br />

CH 3

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