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Anti-inflammatoires non-stéroïdiens (AINS) et paracétamol:

Anti-inflammatoires non-stéroïdiens (AINS) et paracétamol:

Anti-inflammatoires non-stéroïdiens (AINS) et paracétamol:

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Present<br />

Upper GI<br />

tract<br />

Impairment<br />

of mucosal<br />

defense<br />

ulcer<br />

views<br />

Asthmatic<br />

lung<br />

Increased<br />

leucotrienes<br />

production<br />

Bronchoconstriction<br />

on adverse-effects<br />

inhibitors<br />

Coventional<br />

NSAID<br />

Cox-1<br />

inhibition<br />

Platel<strong>et</strong>s<br />

Decreased<br />

TxA 2<br />

production<br />

bleeding<br />

Kidney<br />

Decreased<br />

GFR<br />

Increased<br />

Na reabsption<br />

Oedema<br />

Hypertension<br />

Renal<br />

insufficiency<br />

of Cox-1 / Cox-2<br />

Specific Cox-2<br />

inhibitors<br />

Cox-2<br />

inhibition<br />

Blood<br />

vessels<br />

Decreased<br />

PgI 2<br />

production<br />

Thrombosis<br />

Modified from : Warner TD, Mitchell JA. Cyclooxygenases: new forms, new<br />

inhibitors, and lessons from the clinic. FASEB J. 2004 May;18(7):790-804.<br />

2009-2010 <strong>AINS</strong> <strong>et</strong> parac<strong>et</strong>amol 50

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