Anti-inflammatoires non-stéroïdiens (AINS) et paracétamol:
Anti-inflammatoires non-stéroïdiens (AINS) et paracétamol:
Anti-inflammatoires non-stéroïdiens (AINS) et paracétamol:
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Present<br />
Upper GI<br />
tract<br />
Impairment<br />
of mucosal<br />
defense<br />
ulcer<br />
views<br />
Asthmatic<br />
lung<br />
Increased<br />
leucotrienes<br />
production<br />
Bronchoconstriction<br />
on adverse-effects<br />
inhibitors<br />
Coventional<br />
NSAID<br />
Cox-1<br />
inhibition<br />
Platel<strong>et</strong>s<br />
Decreased<br />
TxA 2<br />
production<br />
bleeding<br />
Kidney<br />
Decreased<br />
GFR<br />
Increased<br />
Na reabsption<br />
Oedema<br />
Hypertension<br />
Renal<br />
insufficiency<br />
of Cox-1 / Cox-2<br />
Specific Cox-2<br />
inhibitors<br />
Cox-2<br />
inhibition<br />
Blood<br />
vessels<br />
Decreased<br />
PgI 2<br />
production<br />
Thrombosis<br />
Modified from : Warner TD, Mitchell JA. Cyclooxygenases: new forms, new<br />
inhibitors, and lessons from the clinic. FASEB J. 2004 May;18(7):790-804.<br />
2009-2010 <strong>AINS</strong> <strong>et</strong> parac<strong>et</strong>amol 50