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Anti-inflammatoires non-stéroïdiens (AINS) et paracétamol:

Anti-inflammatoires non-stéroïdiens (AINS) et paracétamol:

Anti-inflammatoires non-stéroïdiens (AINS) et paracétamol:

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PG (% Control)<br />

Specificity of Celecoxib<br />

120<br />

100J<br />

80<br />

60<br />

40<br />

20<br />

0<br />

J<br />

J<br />

in vivo<br />

J<br />

J<br />

J<br />

0 0.1 1 10 100 500<br />

Dose (mg/kg p.o.)<br />

Gastric PG (COX-1)<br />

J Inflammatory PG (COX-2)<br />

Smith CJ, PNAS, 1998, 95, 13313-18<br />

2009-2010 <strong>AINS</strong> <strong>et</strong> parac<strong>et</strong>amol 44

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