Anti-inflammatoires non-stéroïdiens (AINS) et paracétamol:
Anti-inflammatoires non-stéroïdiens (AINS) et paracétamol:
Anti-inflammatoires non-stéroïdiens (AINS) et paracétamol:
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Why do “coxibs”<br />
bind so tightly to cycoloxygenase-2 ?<br />
the polar sulphonamide side chain tightly bind to hydrophilic “side pock<strong>et</strong>”<br />
Arg 513 and<br />
Hist 90 - forms<br />
hydrogen bonds<br />
with oxygen in<br />
sulphonamide<br />
side chain<br />
Kurumbail RG <strong>et</strong> al. Nature 1996;384:644-8.<br />
+<br />
+<br />
tyrosine at 385<br />
arginine at 120<br />
2009-2010 <strong>AINS</strong> <strong>et</strong> parac<strong>et</strong>amol 40<br />
+
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