preparatis miRebis win yuradRebiT gaecaniT CanarTSi moyvanil ...

CanarTi: informacia pacientebisaTvis
berliprili® plusi 10/25, tabletebi
BERLIPRIL PLUS
enalapril maleati / hidroqloroTiazidi
preparatis miRebis win yuradRebiT gaecaniT CanarTSi moyvanil informacias.
- SeinaxeT mocemuli CanarTi, radgan SeiZleba mogvianebiT dagWirdeT misi
gadakiTxva.
- damatebiTi kiTxvebis SemTxvevaSi, mimarTeT eqims an farmacevts.
- aRniSnuli samkurnalo saSualeba gamowerilia TqvenTvis. dauSvebelia misi
gadacema sxva pirisaTvis. es SesaZloa saziano AaRmoCndes misTvis im SemTxvevaSic
ki, Tu misi simptomebi Tqvensas emTxveva
- gverdiTi movlenebis gaZlierebisas, an iseT gverdiTi moqmedebis gamovlenis
SemTxvevaSi, romelic ar aris aRniSnuli winamdebare CanarTSi, dauyovnebliv
CanarTis Sinaarsi:
1. preparat berliprili® plusis aRwera da gamoyeneba.
2. preparat berliprili® plusis miRebamde.
3. preparat berliprili® plusis miRebis wesi.
4. SesaZlo gverdiTi moqmedebebi.
5. preparat berliprili® plusis Senaxvis pirobebi.
6. damatebiTi informacia.
acnobeT Tqvens mkurnal eqims an farmacevts.
1. preparat berliprili® plusis aRwera da gamoyeneba
berliprili® plusi aris samkurnalo saSualeba, romelic aqveiTebs arteriul wnevas (hipotenziuri
preparati). es aris kombinirebuli preparati, romelic Sedgeba angiotenzingardamqmneli fermentis (agf)
inhibitorisa da Sardmdeni saSualebisagan (hidroqloroTiazidi).
berliprili® plusi gamoiyeneba arteriuli wnevis enalaprilis fonze arasakmarisad daqveiTebisas an
enalaprilisa da hidroqloroTiazidis erTdrouli miRebis nacvlad, romlebic daniSnuli iyo kombinirebuli
preparatis analogiuri dozebiT.
2. preparat berliprili® plusis miRebamde
berliprili® plusi ukunaCvenebia Semdeg SemTxvevebSi:
alergia (momatebuli mgrZnobeloba) moqmedi nivTierebis enalaprilis, sxva agf inhibitorebis an
preparatis romelime komponentis mimarT (ix. paragrafi 6 ~preparat berliprili® plusis Semadgenloba~);
alergia (momatebuli mgrZnobeloba) moqmedi nivTierebis hidroqloroTiazidis an sxva sulfonamidebis
mimarT;
SeSupeba agf inhibitorebis miRebisas (angionevrozuli SeSupeba);
qsovilebis Tandayolili midrekileba SeSupebisadmi an gaurkveveli mizeziT gamowveuli SeSupeba
(memkvidreobiTi an Tandayolili angionevrozuli SeSupeba);
Tirkmelebis funqciis mZime darRvevisas (kreatininis klirensi 30 ml/wT naklebi) da/an dializis
Catarebisas;
RviZlis funqciis mZime darRvevisas;
orsulobis meore da mesame trimestri;
ZuZuTi kvebis periodi.
berliprili® plusi sifrTxiliT unda iqnas gamoyenebuli Semdeg SemTxvevebSi:
- arteriuli wnevis zedmetad daqveiTebis momatebuli riski wylisa da eleqtrolituri cvlis darRvevis
da/an siTxis dakargvis fonze, magaliTad, Sardmdeni saSualebebis miRebis Semdeg, marilis SezRudviT
dietis dacvisas, Rebinebis an diareis dros;
- gulis marcxena parkuWis sarqvelis sanaTuris Seviwroeba an marcxena parkuWidan sisxlis gamodinebis
Semaferxebeli sxva darRveva;
- gulis daavadebebi koronaruli arteriebis sisxlis mimoqcevis darRveviT (gulis iSemiuri daavadeba);
- Tavis tvinis sisxlZarRvebSi sisxlis mimoqcevis darRveva (Tavis tvinis sisxlis mimoqcevis moSla);
- Tirkmlis funqciis saSualo simZimis darRveva (kreatininis klirensi 30-80 ml/wT);
- Tirkmlis arteriebis Seviwroveba (ormxrivi an calmxrivi erTi Tirkmlis funqcionirebis SemTxvevaSi);
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- Tirkmlis transplantacia Catarebuli axlo warsulSi;
- RviZlis fermentebis donis momateba an siyviTlis gamovlena;
- sisxlSi leikocitebis donis Semcireba (leikopenia) an infeqciebisagan damcavi ujredebis raodenobis
gamoxatuli daqveiTeba Tanmxlebi simptomebis gamovleniT (agranulocitozi);
- SemaerTebeli qsovilis zogierTi daavadeba (kolagenozebi), romelic sisxlZarRvebis dazianebiT
mimdinareobs;
- imunuri sistemis damTrgunveli preparatebiT mkurnaloba;
- alopurinoliT (podagris sawinaaRmdego preparati), prokainamidiT (ariTmiebis sawinaaRmdego preparati)
an liTiumis preparatebiT (depresiis zogierTi saxeobis sawinaaRmdego preparati) mkurnaloba;
- momatebuli mgrZnobelobis reaqciebi (alergia) an qsovilebis SeSupeba (angionevrozuli SeSupeba)
berliprili® plusiT mkurnalobisas.
- Saqriani diabeti;
- podagra;
- Seupovari mSrali xvela;
- sisxlSi kaliumis koncentraciis gazrdis momatebuli riski;
- arteriuli wnevis arasakmarisad daqveiTeba eTnikuri kuTvnilebis gamo (gansakuTrebiT Savkanian
pacientebSi).
iseTi simptomebi, rogoricaa simSrale piris RruSi, wyurvili, sisuste, leTargia, kunTebis tkivili an
kunTebis spazmi, gaxSirebuli guliscema, Tavbrusxveva, gulisreva, Rebineba da Sardis gamoyofis Semcireba,
SeiZleba iyos wylis an eleqtrolituri balansis darRvevis niSnebi. maTi gamovlenis SemTxvevaSi dauyovnebliv
mimarTeT eqims.
mwerebis Sxamis (magaliTad, futkris da krazanis) winaaRmdeg mimarTuli madesensibilizebeli Terapiis
Catarebis saWiroebis SemTxvevaSi, berliprili® plusi droebiT unda Canacvldes saTanado preparatiT sxva
jgufis samkurnalo saSualebebdan. winaaRmdeg SemTxvevaSi SeiZleba gamovlindes mZime, sicocxlisaTvis saxifaTo
hipermgrZnobelobis reaqciebi (magaliTad, arteriuli wnevis daqveiTeba, qoSini, Rebineba, kanis alergiuli
reaqciebi). aRniSnul reaqciebs agreTve SeiZleba adgili hqondes mwerebis kbenis SemTxvevaSi (magaliTad,
futkris da krazanis).
garkveuli tipis membranebis (gamtarobis maRali unariT) gamoyenebiT dializis an sisxlSi lipidebis
koncentraciis Sesamcireblad Catarebul mkurnalobasTan (dslp-aferezi deqstransulfatiT absorbciiT) erTad
berliprili® plusis miRebisas SeiZleba gamovlindes momatebuli mgrZnobelobis mZime reaqciebi
sicocxlisTvis saxifaTo Sokur mdgomareobamde.
dializis, hemofiltraciis an dslp-aferezis Catarebamde eqimma unda daginiSnoT sxva Sesabamisi preparati
(magram ara agf inhibitori) an gamoiyenos dializis sxva membraneba.
Tu iRebT berliprili® pluss an gWirdebaT dializis Catareba, acnobeT Tqvens eqims, raTa man gaiTvaliswinos
aRniSnuli garemoeba mkurnalobis daniSvnisas.
Tu operacia an narkozi giwevT (maT Soris stomatologTan viziti) acnobeT Tqvens eqims, rom iRebT
berliprili® pluss, radgan narkozis dros SeiZleba adgili hqondes arteriuli wnevis uecar daqveiTebas.
dauyovnebliv mimarTeT eqims Semdegi simptomebis gamovlenisas:
- saxis, kidurebis, tuCebis, lorwovani garsebis, enisa da/an xorxis SeSupeba, qoSini;
- kanisa da lorwovani garsebis gayviTleba;
- sxeulis temperaturis momateba, limfuri kvanZebis gadideba da/an xaxis anTeba.
aseT SemTxvevaSi unda Sewydes berliprili® plusiT mkurnaloba da daculi iqnas eqimis rekomendaciebi
mkurnalobas Sesaxeb.
berliprili® plusiT mkurnalobis dros saWiroa regularuli vizitebi eqimTan. eqimis mier daniSnuli
gamokvlevebi da analizebi unda Catardes maSinve, gadaudeblad.
hidroqloroTiazidi, romelic Sedis preparatis SemadgenlobaSi, SeiZleba iyos dopinguri testis cru-dadebiTi
pasuxis mizezi.
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erliprili® plusis liTiumis preparatebTan (gamoiyeneba fsiqikuri daavadebebis samkurnalod) kombinaciaSi
gamoyeneba rekomendebuli ar aris.
orsulobis, orsulobaze eWvis an orsulobis dagegmvis SemTxvevaSi aucileblad acnobeT eqims. berliprili®
plusis miReba orsulobis pirvel trimestrSi ar SeiZleba (ix. paragrafi ~orsuloba da laqtacia~).
pacientebi Tirkmelebis funqciis darRveviT
Tirkmelebis funqciis darRvevis mqone pacientebisTvis preparatis doza SeirCeva individualurad.
xandazmuli pacientebi
ar arsebobs monacemebi pacientis asakisa da preparatis efeqturobisa da usafrTxoebis urTierTkavSiris
Sesaxeb.
bavSvebi da mozardebi
bavSvebisaTvis da mozardebisaTvis berliprili® plusis miReba rekomendebuli ar aris, radgan misi efeqturoba
da usafrTxoeba pacientebis aRniSnul jgufSi arasakmarisadaa Seswavlili.
sxva samkurnalo saSualebebis miReba/gamoyeneba
acnobeT eqims an farmacevts Tu iRebT an axlo warsulSi iRebdiT sxva samkurnalo saSualebebs, urecepto
statusis mqone preparatebis CaTvliT.
berliprili® plusis sxva preparatebTan kombinaciis SemTxvevaSi SesaZloa Semdegi gverdiTi moqmedebebi:
Sardmdeni preparatebi, romlebic amcirebs kaliumis gamoyofas (kaliumis damzogveli diurezulebi,
magaliTad, spironolaqtoni, triamtereni an amiloridi), kaliumis Semcveli marilis Semcvlelebi, da
heparini:
sisxlSi kaliumis koncentraciis momateba. mkurnalobis dros eqimma regularulad unda Seamowmos sisxlSi
kaliumis koncentracia.
sxva Sardmdeni saSualebebi (Tiazidebi an maryuJovani diurezulebi), arteriuli wnevis damaqveiTebeli sxva
preparatebi, sisxlZarRvebis gamafarTovebeli preparatebi, depresiis, aseve sxva fsiqikuri daavadebebis
samkurnalo preparatebi (tricikluri antidepresantebi, neirolefsiurebi), sanarkoze saSualebebi,
saanesTezioebi:
arteriuli wnevis mkveTri daqveiTeba.
alkoholi, barbituratebi da sanarkoze analgeziurebi:
arteriuli wnevis Warbi daqveiTeba wamodgomisas vertikalur mdgomareobaSi gadasvlis dros.
liTiumis preparatebi (depresiis zogierTi saxeobis samkurnalo preparati):
liTiumiT mowamvlis momatebuli riski. amitom, berliprili® plusis da liTiumis preparatebis
erTdroulad miReba rekomendebuli ar aris. Tu aRniSnuli kombinaciis gamoyeneba aucilebelia, mkurnalobis
dros saWiroa sisxlSi liTiumis Semcvelobis regularuli kontroli.
tkivilgamayuCebeli da anTebis sawinaaRmdego preparatebi (anTebis sawinaarmdego arasteroiduli
saSualebebi):
arteriuli wnevis arasakmarisad daqveiTeba, sisxlSi kaliumis koncentraciis momateba da Tirkmelebis
funqciis gauareseba; iSviaT SemTxvevebSi – Tirkmelebis mwvave ukmarisoba, gansakuTrebiT Tirkmelebis
funqciis darRvevis mqone pacientebSi.
imunuri sistemis damTrgunveli prparatebi (imunodepresantebi), sistemuri kortikosteroidebi, prokainamidi
(ariTmiis sawinaaRmdego preparatebi):
leikocitebis koncentraciis Semcirebis momatebuli riski mTlianobaSi an maTi calkeuli fraqciis
Semcireba (leikopenia).
citostaturebi (magaliTad, ciklofosfamidi, ftoruracili, meTotreqsati):
Zvlis tvinze toqsiuri moqmedebis gaZliereba (kerZod, granulocitopenia).
podagris sawinaaRmdego preparati (magaliTad, alopurinoli, benzbromaroni):
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podagris samkurnalod SeiZleba saWiro gaxdes preparatis dozis gazrda.
simpaTomimeturebi (bunebrivi mediatorebis norepinefrinis an epinefrinis efeqtebis gamomwvevi saSualebebi,
magaliTad hipotenziuri efeqti) kolestiramini da kolestipoli (sisxlSi lipidebis koncentraciis
damaqveiTebeli preparatebis moqmedi nivTierebebi):
arteriuli wnevis arasakmarisi daqveiTeba.
Saqris damwevi preparatebi da insulini:
SeiZleba saWiro gaxdes Saqris damwevi preparatebis an insulinis dozis Secvla.
amfotericini B (gamoiyeneba sokovani infeqciebis samkurnalod) karbenoqsoloni (kuWis/nawlavebis
wylulovani daavadebis samkurnalod), kortizonis Semcveli preparatebi (kortikosteroidebi),
kortikotropini (hormoni, romelic zegavlenas axdens Tirkmelzeda jirkvlis moqmedebaze) da garkveuli
safaRaraTo saSualebebi:
eleqtrolituri cvlis darRveva, kerZod kaliumis donis daqveiTeba.
kalciumis marilebi:
sisxlSi kalciumis koncentraciis momateba.
sagule glikozidebi (magaliTad, digoqsini, romelic zrdis gulis sistolur moculobas):
sagule glikozidebis efeqtebisa da gverdiTi moqmedebebis gaZliereba.
miorelaqsantebi (magaliTad, tubokurarinis qloridi, romelic adamblavebs kunTebs):
miorelaqsantebis moqmedebis gaZliereba da gaxangrZliveba.
preparatebi, romlebic iwvevs parkuWovani taqiariTmiis ~torsades de pointes~-is ganviTarebas, gulis ritmis
saxifaTo darRveva (magaliTad, zogierTi ariTmiis sawinaaRmdego an fsiqoaqtiuri preparatebi):
parkuWovani taqiariTmiis ~torsades de pointes~-is ganviTarebis riski izrdeba sisxlSi kaliumis
koncentraciis Semcirebisas.
preparati berliprili® plusis sakvebTan da sasmelTan miReba.
sufris marili: arteriuli wnevis arasakmarisi daqveiTeba.
alkoholi: arteriuli wnevis Warbi daqveiTeba.
orsuloba da laqtacia
nebismieri preparatis miRebis win rCevisTvis mimarTeT eqims an farmacevts.
berliprili® plusis miRebamde acnobeT Tqvens eqims Tu orsulad xarT, eWvi gaqvT, rom xarT orsulad,
gegmavT orsulobas an bavSvs ZuZuTi kvebavT.
orsuloba
berliprili® plusi rekomendebuli ar aris orsulobis pirvel trimestrSi.
ar SeiZleba berliprili® plusis miReba orsulobis meore da mesame trimestrSi.
orsulobis dadgenis an dagegmvis SemTxvevaSi saWiroa dauyovnebliv moixsnas berliprili® plusi da dainiSnos
sxva hipotenziuri preparati, radgan mkurnalobis gagrZeleba dakavSirebulia nayofisTvis maRal riskTan.
laqtacia
berliprili® plusis miReba ZuZuTi kvebis periodSi ar SeiZleba, radgan preparatis moqmedi nivTierebebi –
enalaprili da hidroqloroTiazidi – gamoiyofa dedis rZeSi.
zemoqmedeba satransporto saSualebebis marTvis da meqanizmebTan muSaobis unarze
berliprili® plusma SeiZleba Secvalos reaqciis unari, amitom sagzao moZraobaSi monawileoba, meqanizmebis
marTva an muSaoba aramdgradi wonasworobis pirobebSi SeiZleba dakavSirebuli iyos garkveul riskTan. es
gansakuTrebiT xdeba mkurnalobis dasawyisSi, dozis gazrdis da medikamentis Secvlisas, agreTve mkurnalobis
dros alkoholuri sasmelis gamoyenebisas. gaiTvalisiwineT, rom berliprili® plusis miRebas SeiZleba Tan
axldes Tavbrusxveva an sisuste.
mniSvnelovani informacia berliprili® 5-is zogierTi komponentebis Sesaxeb
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aRniSnuli samkurnalo saSualeba Seicavs laqtozas. amitom, Saqris zogierTi saxeobis mimarT autanlobis
SemTxvevaSi, berliprili® plusis miRebamde konsultaciisTvis mimarTeT eqims an farmacevts.
3. preparati berliprili® plusis miRebis wesi.
preparati berliprili® plusi yovelTvis miiReba mkurnali eqimis daniSnulebiT. damatebiTi informaciis
misaRebad, mimarTeT eqims an farmacevts.
SesaZlebelia, kombinirebuli preparatis daniSvnamde eqimma miiRos gadawyvetileba aqtiuri komponentebis
(enalaprilisa da hidroqloroTiazidis) dozis cal-calke SerCevis Sesaxeb. Semdeg, aucileblobis SemTxvevaSi,
eqimi gadagiyvanT berliprili® plusiT mkurnalobaze.
qvemoT naCvenebia preparatis Cveulebrivi doza, Tu eqimis mier sxvagvarad ar aris daniSnuli.
1 tableti berliprili® plusi erTxel dRe-RameSi.
miTiTeba:
ori preparatis miRebidan berliprili® plusis miRebaze gadasvlisas SesaZlebelia moxdes arteriuli wnevis
Warbi daqveiTeba. xSirad es aRiniSneba wyal-marilovani balansis darRvevis mqone pacientebSi (magaliTad,
Rebinebis, diareis, Sardmdeni saSualebebis miRebis Semdeg), aseve gulis mZime ukmarisobis an maRali arteriuli
wnevis dros, rac dakavSirebulia Tirkmelebis mZime simptomebTan an daavadebebTan. amitom, berliprili® plusis
pirveli tabletis miRebis Semdeg Tqven SesaZloa, darCeT eqimis kontrolis qveS 8 saaTis ganmavlobaSi
miRebis wesi:
berliprili® plusis miReba SeiZleba kvebisgan damoukideblad. daniSnuli sadReRamiso doza miiReba diliT,
sakmarisi raodenobis siTxesTan erTad, (magaliTad, Wiqa wyali).
gamyofi xazi gamiznulia tabletis gasayofad ylapvis gasaadvileblad da ara tabletis Tanabar dozebad
gasayofad.
miRebis xangrZlivoba
mkurnalobis xangrZlivobas gansazRvravs eqimi.
Tu fiqrobT, rom preparati berliprili® plusis moqmedeba Zalian Zlieri an sustia, mimarTeT mkurnal eqims
an farmacevts.
berliprili® plusis dozis gadaWarbebis SemTxvevaSi
preparatis dozis SemTxveviT gadaWarbebisas, dauyovnebliv mimarTeT eqims an daukavSirdiT saswrafo daxmarebis
eqims. mowamvlis simZimis mixedviT eqimi miiRebs saTanado zomebs.
dozis gadaWarbebis xarisxis Sesabamisad SesaZlebelia Semdegi simptomebis gamovlena: xSiri da uxvi Sardva,
eleqtrolituri balansis darRveva, arteriuli wnevis mniSvnelovani dacema, gonebis dabindva an dakargva,
krunCxvebi, msubuqi xarisxis dambla, gulis ritmis darRveva, pulsis Seneleba an gaxSireba, sisxlZarRvovani
ukmarisoba, Tirkmelebis ukmarisoba.
dozis gadaWarbebaze eWvis SemTxvevaSi dauyovnebliv mimarTeT eqims.
preparati berliprili® plusis dozis gamotoveba
gamotovebuli dozis kompensaciis mizniT preparatis ormagi doziT miReba ar SeiZleba.
preparati berliprili® plusis miRebis Sewyveta
ar SewyvitoT berliprili® plusiT mkurnaloba mkurnal eqimTan winaswari konsultaciis gareSe!
mkurnalobasTan dakavSirebul nebismier sakiTxze rCevisaTvis mimarTeT eqims an farmacevts.
4. SesaZlo gverdiTi moqmedebebi.
rogorc yvela sxva samkurnalo saSualebas, berliprili® plussac SeiZleba hqondes gverdiTi moqmedebebi,
Tumca is ar vlindeba yvela pacientSi. im SemTxvevaSi, Tu romelime gverdiTi movlena gagirTuldaT, an
SeniSnavT iseT gverdiT moqmedebas, romelic ar aris aRniSnuli winamdebare CanarTSi, SeatyobineT mkurnal
eqims an farmacevts.
gverdiTi moqmedebebi an simptomebi, romlebic saWiroebs yuradRebas, da amasTan dakavSirebuli sifrTxilis
zomebi.
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xorxis, saxmo iogebis da/an enis qsovilebis SeSupebis dros (angionevrozuli SeSupeba), dauyovnebliv mimarTeT
mkurnal eqims, romelic miiRebs sifrTxilis zomebs.
siyviTlis niSnebis gamovlenis SemTxvevaSi SewyviteT preparatis miReba da mimarTeT eqims.
sxeulis temperaturis momatebisas, limfuri kvanZebis gadidebis da/an yelis anTebis SemTxvevaSi saWiroa
agreTve eqimTan mimarTva, romelic daniSnavs sisxlis analizs da Seamowmebs leikocitebis dones.
berliprili® plusiT mkurnalobis fonze zemoT aRwerili nebismieri movlenis SemTxvevaSi dauyovnebliv
acnobeT eqims.
sxva SesaZlo gverdiTi moqmedeba
gverdiTi moqmedebebis Sefasebas safuZvlad udevs maTi gamovlenis sixSiris Semdegi monacemebi:
Zalian xSirad:
10 namkurnalevi pacientidan 1-ze mets
xSirad:
10 namkurnalevi pacientidan 1-ze naklebs da 100 pacientidan 1-ze mets
zogjer:
iSviaTad:
Zalian iSviaTad:
infeqciebi:
iSviaTad:
100 namkurnalevi pacientidan 1-ze naklebs da 1000 pacientidan 1-ze mets
1000 namkurnalevi pacientidan 1-ze naklebs da 10000 pacientidan 1-ze mets
10 000 namkurnalevi pacientidan 1-ze naklebs, an SemTxvevebi ar aris
aRwerili.
sanerwyve jirkvlebis anTeba.
darRvevebi sisxlis warmoqmnisa da limfuri sistemas mxriv
zogjer:
anemia eriTrocitebis gaZlierebuli daSlis (hemolizuri anemia) an Zvlis tvinSi
sisxlis warmoqmnis darRvevis fonze (aplasturi anemia).
iSviaTad:
sisxlis zogierTi ujredebis koncentraciis Semcireba (leikopenia, neitropenia,
Trombocitopenia, pancitopenia) garkveuli saxis leikocitebis raodenobis gamoxatul
Semcirebamde (agranulocitozi), zogierTi laboratoriuli parametris daqveiTeba
(hemoglobini da hematokriti), Zvlis tvinis funqciis darRveva (Zvlis tvinis funqciis
daTrgunva), limfuri kvanZebis gadideba, autoimunuri daavadebebi.
kvebisa da nivTierebaTa cvlis darRveva
Zalian xSiarad: sisxlSi glukozis koncentraciis momateba, SardSi glukozis gamovlena, sisxlSi
SardmJavas koncentraciis momateba, eleqtrolituri cvlis darRveva (natriumis
deficiti, kaliumis deficiti), sisxlSi lipidebis (qolesterinisa da
trigliceridebis) donis momateba.
zogjer:
Zalian iSviaTad:
sisxlSi glukozis koncentraciis daqveiTeba.
sisxlis pH momateba.
fsiqikuri darRvevebi:
xSirad: depresia.
iSviaTad:
mousvenroba.
nervulis sistema:
xSirad:
zogjer:
iSviaTad:
gulis wasvlis SegrZneba, Tavis tkivili
cnobierebis moSla, Zilianoba, uZiloba, gaRizianebadoba, uCveulo SegrZnebebi kanis
mxriv (magaliTad, Cxvleta, wva), Zlieri Tavbrusxveva.
uCveulo sizmrebi, Zilis darRveva.
mxedvelobis organoebi
Zalian xSirad: aramkveTri mxedveloba.
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zogjer:
garemos aRqma yviTel ferSi, mxedveloba gardamavali dabindva.
smenis organoebi:
zogjer: xmauri yurebSi (tinnitusi).
guli:
xSirad:
tkivili gul-mkerdis areSi, gulis ritmis darRveva, moWeriTi xasiaTis tkivili
mkerdis Zvlis ukan (stenokardia), gaxSirebuli pulsi, gaxSirebuli guliscema.
sisxlZarRvebi:
Zalian xSirad: Tavbrusxveva.
xSirad:
arteriuli wnevis Warbi daqveiTeba, magaliTad adgomisas, gonebis xanmokle dakargva
(gulis wasvla), gulis Seteva an insulti, SesaZloa gulis kunTSi da/an Tavis
tvinSi sisxlis mimoqcevis darRvevis mqone pacientebSi wnevis gamoxatuli daqveiTebis
Sedegad.
iSviaTad:
xelis mtevnebSi da terfebSi sixlis mimoqcevis moSla, romelic gamowveulia
sisxlZarRvTa spazmiT (reinos sindromi), wvrili sisxlZarRvebis anTeba.
sunTqvis organoebi:
Zalian xSirad: xvela.
xSirad:
qoSini (maT Soris pnevmoniisa da filtvebSi siTxis dagrovebisas).
zogjer:
surdo, tkivili yelis areSi da xmis CaxleCva, bronqebis spazmi, asTma.
iSviaTad:
cvlilebebi filtvebis qsovilSi (infiltratebi), sinusiti, alergiuli xasiaTis
anTebiTi procesebi filtvebSi.
kuW-nawlavis traqti:
Zalian xSirad: gulisreva.
xSirad:
diarea, Sekruloba, tkivili kuWis areSi, gemos aRqmis Secvla, kuWis gaRizianeba,
kuWqveSa jirkvlis anTeba.
zogjer:
nawlavuri gauvaloba, Rebineba, saWmlis monelebis procesis darRveva, madis dakargva,
piris simSrale, kuWis wyluli.
iSviaTad:
piris Rrus lorwovani garsis wylulovani anTeba, enis lorwovani garsis anTeba.
Zalian iSviaTad: nawlavebis qsovilis SeSupeba (angionevrozuli SeSupebis nawlavuri forma).
RviZli da naRvlis gamomyofi gzebi:
zogjer: siyviTle.
iSviaTad:
RviZlis ukmarisoba, hepatiti (RviZlis ujredebis nekrozamde).
kani:
xSirad:
zogjer:
iSviaTad:
gamonayari, qsovilebis momatebuli mgrZnobelobis/SeSupebis reaqciebi (angionevrozuli
SeSupeba).AaRwerilia angionevrozuli SeSupebis SemTxvevebi saxis, kidurebis, tuCebis,
enis, saxmo iogebis da/an xorxis dazianebiT.
gaZlierebuli ofldena, qavili, WinWris cieba, Tmis cvena, kanis mzis sxivebis mimarT
momatebuli mgrZnobeloba, gamonayari.
seriozuli reaqciebi kanis mxriv (polimorfuli eriTema, stivens-jonsonis sindromi,
eqsfoliaturi dermatiti, toqsiuri epidermuli nekrolizi, pemfigusi, eriTrodermia),
sistemuri wiTeli mgluras msgavsi kanis reaqciebi (kanis dazianebiT mimdinare
autoimunuri daavadeba), sistemuri wiTeli mgluras kanis formis recidivi, momatebuli
mgrZnobelobis mZime reaqciebi.
aRwerilia simptomokompleqsi, romelic SeiZleba moicavdes Semdeg gverdiT movlenebs:, sxeulis temperaturis
momateba, serozuli garsebis anTeba (magaliTad, plevris), sisxlZarRvebis anTeba, kunTebis tkivili an anTeba,
saxsrebis tkivili da saxsrebis anTeba da laboratoriuli maCveneblebis zogierTi gadaxra (sisxlSi
antibirTvuli antisxeulebis dadebiTi titri, eriTrocitebis daleqvis siCqaris momateba, eozinofilia da
leikocitozi). aseve, SeiZleba adgili hqondes kanze gamonayars, mzis sxivebis mimarT mgrZnobelobis momatebas
da sxva reaqciebs kanis mxriv.
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sayrden-mamoZravebeli aparati
zogjer: kunTebis krunCxva.
Tirkmelebi da Sardgamomyofi gzebi:
zogjer:
Tirkmelebis funqciis darRveva, Tirkmelebis ukmarisoba, cilebis gamoyofa SardTan
erTad, Tirkmelebis mwvave anTeba.
iSviaTad:
gamoyofili Sardis moculobis Semcireba.
sasqeso sistema da sarZeve jirkvlebi
zogjer: impotencia.
iSviaTad:
sarZeve jirkvlis gadideba mamakacebSi.
sistemuri darRvevebi
Zalian xSirad: sisuste.
xSirad: momatebuli daRliloba.
zogjer:
saxis gawiTleba (wamoxureba), zogadi sisuste, sxeulis temperaturis momateba,
laboratoriuli maCveneblebi
xSirad:
sisxlSi kaliumis, Sardovanas, SardmJavas da/an kreatininis koncentraciis momateba.
zogjer:
sisxlSi natriumis koncentraciis Semcireba.
iSviaTad: RviZlis maCveneblebis (RviZlis fermentebis aqtiurobis, SratSi bilirubinis
koncentraciis) momateba.
5. preparati berliprili® plusis Senaxvis pirobebi
samkurnalo saSualeba inaxeba bavSvebisaTvis miuwvdomel adgilas.
3 weli. preparati ar gamoiyeneba vargisianobis vadis gasvlis Semdeg, romelic miTiTebulia muyaos kolofze
da blisterze. vargisianobis vadis gasvlis TariRi gulisxmobs miTiTebuli Tvis bolo dRes.
samkurnalo saSualebebis kanalizaciis milSi an nagavTan gadagdeba ar SeiZleba. preparatis utilizaciis
sakiTxTan dakavSirebiT mimarTeT farmacevts. aRniSnuli zomebi xels Seuwyobs garemos dacvas.
enaxvis pirobebi
preparati inaxeba ara umetes 30 ˚C temperaturaze.
tenisagan dacul adgilas da originalur SefuTvaSi.
6. damatebiTi informacia
preparati berliprili® plusis Semadgenloba
preparatis moqmed nivTierebebs warmoadgens enalapril maleati da hidroqloroTiazidi. yoveli tableti
Seicavs 10mg enalapril maleats da 25mg hidroqloroTiazids.
damxmare komponentebi: laqtozis monohidrati, magniumis karbonati ZiriTadi, msubuqi, Jelatini,
karboqsimeTilsaxameblis natriumis marili (tipi A), siliciumis dioqsidi koloiduri uwylo, magniumis
stearati, rkinis oqsidis yviTeli hidrati (E172).
preparati berliprili® plusis aRwera da SefuTva
Ria-yviTeli brtyeli tabletebi paraleluri zedapirebiT, CamoWrili kideebiT da gamyofi zoliT erT mxares.
SefuTvSi moTavsebulia berliprili® plusis 30, 50 da 100 tableti.
SeiZleba bazarze yvela saxis SefuTva ar iyos warmodgenili.
afTiaqidan gacemis piroba
farmacevtuli produqtis jgufi II (gacemis reJimi: receptiT).
registraciis mflobeli da mwarmoebeli
berlin-xemi ag (menarini grup)
gliniker veg 125, 12489 berlini, germania
CanarTis bolo redaqtirebis TariRi: 10/2008
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