04 Lezione dalla 4 alla 7 Modulo 2 - ctf novara
04 Lezione dalla 4 alla 7 Modulo 2 - ctf novara
04 Lezione dalla 4 alla 7 Modulo 2 - ctf novara
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Cell-associated<br />
pattern recognition<br />
receptors<br />
Toll-like receptors<br />
C-type lectins<br />
Scavenger receptors<br />
NLRs<br />
N-formyl Met-Leu-Phe receptors<br />
Soluble recognition<br />
molecules<br />
Pentraxins<br />
Collectins<br />
Ficolins<br />
Location<br />
Plasma membrane and endosomal<br />
membranes of dendritic cells, phagocytes,<br />
endothelial cells, and many other cell types<br />
Plasma membranes of phagocytes<br />
Plasma membranes of phagocytes<br />
Cytoplasm of phagocytes and other cells<br />
Plasma membranes of phagocytes<br />
Location<br />
Plasma<br />
Plasma<br />
Alveoli<br />
Plasma<br />
Specific examples and their<br />
PAMP ligands<br />
TLRs 1-9: Various bacterial and viral molecules<br />
(see Fig. 2-2)<br />
Mannose receptor: Microbial surface<br />
carbohydrates<br />
with terminal mannose and fructose<br />
Dectin: Glucans present in fungal cell walls<br />
CD36: microbial diacylglycerides<br />
Nod1, Nod2 and NALP3: bacterial peptidoglycans<br />
FPR and FPRL1: peptides containing Nformylmethionyl<br />
residues<br />
Specific examples and their<br />
PAMP ligands<br />
C reactive protein (CRP): Microbial<br />
phosphorylcholine<br />
and phosphatidylethanolamine<br />
Mannose-binding lectin (MBL): Carbohydrates<br />
with<br />
terminal mannose and fructose<br />
Surfactant proteins SP-A and SP-D: Various<br />
microbial structures<br />
Ficolin: N-acetylglucosamine and lipoteichoic<br />
acid components<br />
of the cell walls of gram-positive bacteria
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