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04 Lezione dalla 4 alla 7 Modulo 2 - ctf novara

04 Lezione dalla 4 alla 7 Modulo 2 - ctf novara

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Evidence for frequent but not universal correlation between<br />

TAM number/density and prognosis in human malignancies.<br />

(Bingle L. et al. J. Pathol. 2002)<br />

(Extensive TAM infiltration)<br />

Prognosis:<br />

Type of cancer:<br />

Breast poor<br />

Cervix poor<br />

Bladder poor<br />

Lung poor<br />

Lymphoma poor<br />

Cytotoxicity<br />

Growth factors, vascular reactions<br />

angiogenesis (direct or via IL-1/TNF)<br />

(direct, via PCA → fibrin)<br />

(Mantovani et al Immunol Today 1992)

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