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12 - IRSA - Cnr

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Fig. 2 - Tipico cromatogramma ottenuto analizzando<br />

un’acqua superficiale (fiume Tevere) con rivelatori UV e<br />

fluorescenza (FL). 1: Carbamazepina; 3: Ketoprofene;<br />

5: Naproxene; 9: Diclofenac; 10: Ibuprofene; 11:<br />

Gemfibrozil.<br />

BIBLIOGRAFIA<br />

BAKER D.R., KASPRZYK-HORDERN B. (2011):<br />

“Critical evaluation of methodology commonly used<br />

in a sample collection, storage and preparation for<br />

the analysis of pharmaceuticals and illicit drugs in<br />

surface water and wastewater by solid phase<br />

extraction and liquid chromatography-mass<br />

spectrometry”, J. Chromatogr. A., <strong>12</strong>18, 7901-7913.<br />

BOTTONI P., BARRA CARACCIOLO A. (2010):<br />

“Pharmaceutical as priority water contaminants”,<br />

Toxicol. Environ. Chem., 92, 549-565.<br />

CASTIGLIONI S., FANELLI R., CALAMARI D.,<br />

BAGNATI R., ZUCCATO E. (2004): ”Methodological<br />

approaches for studying pharmaceuticals in the<br />

environment by comparing predicted and measured<br />

concentrations in River Po, Italy”, Regul. Toxicol.<br />

Pharmacol., 39, 25-32.<br />

Notiziario dei Metodi Analitici<br />

35<br />

n.1 (20<strong>12</strong>)<br />

Fig. 3 - Tipico cromatogramma ottenuto analizzando un<br />

effluente con rivelatori UV e fluorescenza (FL). 1:<br />

Carbamazepina; 3: Ketoprofene; 5: Naproxene; 9:<br />

Diclofenac; 10: Ibuprofene; 11: Gemfibrozil.<br />

EUROPEAN MEDICINES AGENCY/COMMITTEE<br />

for MEDICINAL PRODUCTS for HUMAN USE<br />

(EMEA/CHMP) (2006): “Guideline on the<br />

environmental risk assessment of medicinal<br />

products for human use”, London, UK, EMEA,<br />

EMEA/CHMP/SWP/4447/00.<br />

FENT K., WESTON A.A., CAMINADA D. (2006):<br />

“Review ecotoxicology of human pharmaceuticals”,<br />

Aquat. Toxicol., 76, <strong>12</strong>2-159.<br />

GONZÀLEZ ALONSO S., CATALÀ M., MAROTO<br />

R.R., RODRÌGUEZ GIL J.L., GIL DE MIGUEL A.,<br />

VALCÀRCEL Y. (2010): “Pollution by psychoactive<br />

pharmaceuticals in the Rivers of Madrid<br />

metropolitan area (Spain)”, Environ. Intern., 36, 195-<br />

201.

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