urotoli
urotoli
urotoli
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preparati aqveiTebs Sardgamomyofi gzebis gluvi muskulaturis tonuss,<br />
detruzoris kumSvadobis aqtivobas, aseve amcirebs nerwyvdenas.<br />
Terapiulze maRali dozebis miRebisas iwvevs Sardis buStis arasrul<br />
daclas da zrdis darCenili Sardis raodenobas.<br />
tolterodinis Terapiuli efeqti miiRweva 4 kviraSi.<br />
tolterodini ar ainhibirebs CYP2D6, 2C19, 3A4 da 1A2.<br />
farmakokinetika<br />
Sewova<br />
preparatis SigniT miRebisas tolterodini swrafad Seiwoveba kuW-nawlavis<br />
traqtidan (knt). SratSi maqsimaluri koncentracia (C max ) miiRweva 1-2 saaTSi.<br />
Terapiuli dozebis intervaliT (1-4 mg) miRebisas arsebobs xazovani<br />
damokidebuleba sisxlis SratSi C max mniSvnelobasa da preparatis dozas<br />
Soris.<br />
tolterodinis sruli bioSeRwevadoba Seadgens 65%-s CYP2D6 ukmarisobis<br />
mqone pirebSi da 17%-s pacientTa umravlesobaSi.<br />
sakvebi ar moqmedebs preparatis bioSeRwevadobaze, magram tolterodinis<br />
koncentracia izrdeba misi sakvebTan miRebisas.<br />
ganawileba<br />
tolterodini da 5-hidroqsimeTiluri metaboliti ukavSirdeba upiratesad<br />
orozomukoids. SeukavSirebeli fraqciebi Seadgens 3,7% da 36%, Sesabamisad.<br />
tolterodinis ganawilebis moculoba Seadgens 113 l.<br />
tolterodinisa da 5-hidroqsimeTiluri metabolitis cilebTan SekavSirebis<br />
gansxvavebis gamo tolterodinis mrudis qveS farTobi ~koncentracia – dros~<br />
(AUC) CYP2D6 ukmarisobis mqone pirebSi axlosaa tolterodinisa da 5-<br />
hidroqsimeTiluri metabolitis AUC sidideebis jamTan pacientTa<br />
umravlesobaSi dozirebis erTnairi reJimis dros. aqedan gamomdinare,<br />
preparatis usafrTxoeba, amtanoba da klinikuri efeqti ar aris damokidebuli<br />
CYP2D6 aqtivobaze.<br />
metabolizmi<br />
tolterodini ZiriTadad metabolizdeba RviZlSi polimorfuli fermenti<br />
CYP2D6 saSualebiT farmakologiurad aqtiuri 5-hidroqsimeTiluri<br />
metabolitis warmoqmniT, romelic Semdeg metabolizdeba 5-karbonis mJava da<br />
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