urotoli
urotoli
urotoli
Create successful ePaper yourself
Turn your PDF publications into a flip-book with our unique Google optimized e-Paper software.
N-dezalkilirebul 5-karbonis mJavamde. 5-hidroqsimeTilur metabolits aqvs<br />
tolterodinis msgavsi farmakologiuri Tvisebebi da umravles avadmyofSi<br />
arsebiTad aZlierebs preparatis moqmedebas.<br />
daqveiTebuli metabolizmis (CYP2D6 ukmarisobiT) mqone pirebSi tolterodini<br />
ganicdis dezalkilirebas CYP3A4 izofermentebiT N-dezalkilirebuli<br />
tolterodinis warmoqmniT, romelsac ar gaaCnia farmakologiuri aqtivoba.<br />
gamoyofa<br />
SratSi tolterodinis sistemuri klirensi umravles pacientSi Seadgens<br />
daaxloebiT 30l/sT. preparatis miRebisas tolterodinis naxevradgamoyofis<br />
periodi (T 1/2 ) Seadgens 2-3 saaTs, xolo 5-hidroqsimeTiluri metabolitis T 1/2 –<br />
3-4 saaTs. daqveiTebuli metabolizmis mqone pirebSi T 1/2 daaxloebiT 10 saaTia.<br />
sawyisi SeerTebis klirensis daqveiTeba CYP2D6 ukmarisobis mqone pirebSi<br />
iwvevs tolterodinis koncentraciis gazrdas (daaxloebiT 7 jer) gamovlenas<br />
dauqvemdebarebeli 5-hidroqsimeTiluri metabolitis koncentraciebis fonze.<br />
tolterodinis daaxloebiT 77% gamoiyofa SardTan da 17 % - ganavalTan.<br />
dozis 1%-ze naklebi gamoiyofa Seucvleli saxiT da daaxloebiT 4% - 5-<br />
hidroqsimeTiluri metabolitis saxiT. 5-karbonis mJava da N-<br />
dezalkilirebuli 5-karbonis mJava Seadgens, Sesabamisad, SardTan<br />
gamoyofili raodenobis daaxloebiT 51% da 29%.<br />
farmakokinetika gansakuTrebul klinikur pirobebSi<br />
tolterodinisa da misi aqtiuri 5-hidroqsimeTiluri metabolitis AUC sidide<br />
izrdeba daaxloebiT 2 jer avadmyofebSi RviZlis ciroziT.<br />
tolterodinisa da 5-hidroqsimeTiluri metabolitis AUC saSualo sidide 2<br />
jer maRalia pacientebSi Tirkmelebis funqciis gamoxatuli darRveviT<br />
(gorgolovani filtraciis siCqare