8_Giovanna Masala - Centro per lo Studio e la Prevenzione ...

More documents

Recommendations

Info

Influence of pre- and postdiagnosis physical activity on mortality in breast cancer survivors: the health, eating, activity, and lifestyle study Irwin ML, Smith AW, McTiernan A, Ballard-Barbash R, Cronin K, Gilliland FD, Baumgartner RN, Baumgartner KB, Bernstein L. J Clin Oncol. 2008 Aug 20;26(24):3958-64. PURPOSE: To investigate the association between pre- and postdiagnosis physical activity (as well as change in prediagnosis to postdiagnosis physical activity) and mortality among women with breast cancer. PATIENTS AND METHODS: This was a prospective observational study of 933 women enrolled onto the Health, Eating, Activity, and Lifestyle Study who were diagnosed with local or regional breast cancer between 1995 and 1998 and observed until death or September 2004, whichever came first. The primary outcomes measured were total deaths and breast cancer deaths. The primary exposures were physical activity in the year before and 2 years after diagnosis and the pre- to postdiagnosis change in physical activity. RESULTS: Compared with inactive women, the multivariable hazard ratios (HRs) for total deaths for women expending at least 9 metabolic equivalent hours per week (approximately 2 to 3 h/wk of brisk walking) were 0.69 (95% CI, 0.45 to 1.06; P = .045) for those active in the year before diagnosis and 0.33 (95% CI, 0.15 to 0.73; P = .046) for those active 2 years after diagnosis. Compared with women who were inactive both before and after diagnosis, women who increased physical activity after diagnosis had a 45% lower risk of death (HR = 0.55; 95% CI, 0.22 to 1.38), and women who decreased physical activity after diagnosis had a four-fold greater risk of death (HR = 3.95; 95% CI, 1.45 to 10.50). CONCLUSION: Moderate-intensity physical activity after a diagnosis of breast cancer may improve prognosis.
• Una serie di studi di intervento, in genere di piccole dimensioni, hanno cercato di valutare l’effetto dell’esercizio fisico su outcomes diversi quali la qualità della vita, misurata tramite questionari ad hoc, il grado di allenamento e i sintomi di affaticamento. • Sia per le ridotte dimensioni che per la breve durata del follow-up, la maggior parte non ha fornito indicazioni sull’effetto a lungo termine e in genere sulla prognosi di malattia. Inoltre va sottolineata la varietà di schemi di esercizio fisico proposti e l’eterogeneità nella caratteristiche cliniche delle pazienti, ad esempio in relazione allo stadio di malattia o alla fase di trattamento.
Page 1 and 2: ALIMENTAZIONE COME PREVENZIONE GIOV
Page 3 and 4: Raccomandazioni per la prevenzione
Page 5 and 6: WCRF-AICR 2°Report, 2007
Page 7 and 8: WCRF-AICR 2007 2°Report
Page 9 and 10: CONTROLLO DEL PESO - studi osservaz
Page 11 and 12: Obesità e tumore della mammella La
Page 13: Regulation of plasma steroid hormon
Page 20 and 21: da A. McTiernan “Mechanisms linki
Page 22 and 23: Studio prospettico WHEL n. 1490 fol
Page 24 and 25: ALIMENTAZIONE STUDI DI INTERVENTO R
Page 26 and 27: Dopo un follow up mediano di 60 mes
Page 28 and 29: WHEL STUDY Pierce et al JAMA 2007
Page 30 and 31: IN ITALIA è attualmente in corso l
Page 32: CONCLUSIONI Le evidenze attualmente

8_Giovanna Masala - Centro per lo Studio e la Prevenzione ...

Create successful ePaper yourself

Delete template?

Save as template?