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Popolazione di confronto: nazionale e regionale. Tassi sesso età e periodo specifici Eliminato dal calcolo del periodo a rischio il tempo successivo ad un eventuale intervento di colectomia totale e/o resezione del retto Usando la popolazione toscana come confronto l’unica differenza sostanziale riguarda la mortalità per patologia gastrointestinale SMR 2.12 95%CI 1.05-3.80
Extended mortality follow-up of a cohort of dry cleaners. Blair A, Petralia SA, Stewart PA. Ann Epidemiol. 2003 Jan;13(1):50-6. PURPOSE: The mortality follow-up of a cohort of dry cleaners was extended to further evaluate cancers risks associated with organic solvents. METHODS: The underlying and contributing causes of death among 5,369 members of a dry cleaning union in St. Louis were determined through December 31, 1993. The mortality experience of the cohort was compared to that of the US population adjusted for age at entry, year of death, race and gender. RESULTS: The total mortality was about as expected (SMR = 1.0, N = 2351, 95% CI = 1.0-1.1). Excesses were observed for emphysema (SMR = 1.7, N = 21, 95% CI = 1.0-2.5), Hodgkin's disease (SMR = 2.0, N = 5, 95% CI = 0.6-4.6) and cancers of the esophagus (SMR = 2.2, N = 26, 95% CI = 1.5-3.3), larynx (SMR = 1.7, N = 6, 95% CI = 0.6-3.7), lung (SMR = 1.4, N = 125), 95% CI = 1.1-1.6), and cervix (SMR = 1.6, N = 27, 95% CI = 1.0-2.3). These excesses occurred among men and women and blacks and whites. Bladder cancer was elevated among white men and women and kidney cancer among black men and women, but not significantly so. None of these causes of death showed strong relationships with duration or estimated level of exposure to dry cleaning solvents, although relative risks for cancers of the larynx, lung and kidney were larger among subjects estimated to have higher levels of exposure and risks from bladder cancer and chronic nephritis were greater among persons who entered the union after 1960. CONCLUSION: The excesses observed are unlikely to be due to chance because most occurred in earlier as well as the recent follow-up. The specific factors contributing the excesses, however, are not clear. Socioeconomic, lifestyle, and occupational exposures are all possibilities. Lack of information on socioeconomic and lifestyle factors hampers evaluation.
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Gli studi di coorte: disegno e cenn
Page 3 and 4:
Studio di Coorte E’ un tipo di st
Page 5 and 6:
FUMO DI TABACCO E MALATTIE CRONICHE
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STUDIO PROSPETTICO (STUDIO DI COORT
Page 9 and 10: POPOLAZIONE CHIUSA N Popolazione-te
Page 11 and 12: Studi di record linkage Si tratta d
Page 13 and 14: EPIC European Prospective Investiga
Page 15 and 16: EPIC ARRUOLAMENTO dati anagrafici O
Page 17: PRELIEVO EMATICO • A DIGIUNO •
Page 20 and 21: QUESTIONARIO STILE DI VITA in due v
Page 22 and 23: Identificazione della coorte • Mo
Page 24 and 25: Accertamento dell'esposizione L'inf
Page 26 and 27: Problemi di misclassificazione Uso
Page 28 and 29: Confondenti Negli studi prospettici
Page 30 and 31: PROCEDURE FOLLOW-UP EPIC DATABASE A
Page 32 and 33: Problemi di validità Accertamento
Page 34 and 35: Modalità e durata follow-up E' nec
Page 36 and 37: Esempi 1. Incidenza di infortuni in
Page 38 and 39: ESEMPIO t 0 Years = evento X= deces
Page 40 and 41: Per ogni membro della coorte si dev
Page 42 and 43: Persi al follow-up Soggetti dei qua
Page 44 and 45: Scelta della popolazione (gruppo) d
Page 46 and 47: Confronto esterno Quando la coorte
Page 48 and 49: Analisi I Confronto con una coorte
Page 50: Rischio di t. mammella e contraccet
Page 53: da Folsom AR and Demissie Z Am J Ep
Page 56 and 57: Tassi di mortalità nazionale per t
Page 58 and 59: "Effetto Lavoratore Sano" "Healthy
Page 62 and 63: Analisi Caso controllo “nested
Page 64 and 65: CagA+ Helicobacter pylori infection
Page 66 and 67: Lo studio caso-coorte Il termine
Page 68 and 69: Esempio di applicazione: Il progett
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