fattori di rischio modificabili per il tumore della mammella

More documents

Recommendations

Info

Densità mammograficaBassa densità mammograficaElevata densità mammografica la densità elevata rappresenta un fattore di rischio per il tumore del senoè influenzata da fattori che a loro volta modulano il rischio di tumore è modificabilePotenziale variabile surrogato per studiare l’effetto di diversitipi di interventi di prevenzione per il tumore del senoInformazione potenzialmente disponibile per un elevato numero didonne (partecipanti ai programmi di screening)
Breast density and parenchymal patterns as markers of breast cancerrisk: a meta-analysis.McCormack VA, dos Santos Silva I. Cancer Epidemiol Biomarkers Prev. 2006 15:1159-69.Mammographic features are associated with breast cancer risk, but estimates of the strength of theassociation vary markedly between studies, and it is uncertain whether the association is modified byother risk factors. We conducted a systematic review and meta-analysis of publications onmammographic patterns in relation to breast cancer risk. Random effects models were used tocombine study-specific relative risks. Aggregate data for > 14,000 cases and 226,000 noncasesfrom 42 studies were included. Associations were consistent in studies conducted in the generalpopulation but were highly heterogeneous in symptomatic populations. They were much stronger forpercentage density than for Wolfe grade or Breast Imaging Reporting and Data System classificationand were 20% to 30% stronger in studies of incident than of prevalent cancer. No differences wereobserved by age/menopausal status at mammography or by ethnicity. For percentage densitymeasured using prediagnostic mammograms, combined relative risks of incident breastcancer in the general population were 1.79 (95% confidence interval, 1.48-2.16), 2.11 (1.70-2.63), 2.92 (2.49-3.42), and 4.64 (3.64-5.91) for categories 5% to 24%, 25% to 49%, 50% to 74%,and > or = 75% relative to < 5%. This association remained strong after excluding cancersdiagnosed in the first-year postmammography. This review explains some of the heterogeneity inassociations of breast density with breast cancer risk and shows that, in well-conductedstudies, this is one of the strongest risk factors for breast cancer. It also refutes thesuggestion that the association is an artifact of masking bias or that it is only present in arestricted age range.
Page 1 and 2: FATTORI DI RISCHIO MODIFICABILIPER
Page 4 and 5: Mean height of women born between 1
Page 6 and 7: ORMONI E STORIA RIPRODUTTIVA
Page 8 and 9: un figlio in più riduce il rischio
Page 10 and 11: Serum sex steroidsIn premenopausalw
Page 12 and 13: Obesità e tumore della mammella‣
Page 15 and 16: ALIMENTAZIONEE TUMORE DELLA MAMMELL
Page 17 and 18: Pooling Project of Prospective Stud
Page 20 and 21: Dietary fat and breast cancer risk
Page 22: Am J Epidemiol 2005 Jan 15;161(2):1
Page 25 and 26: ‣Nella coorte italiana ORDET una
Page 27 and 28: Numerosi studi epidemiologici hanno
Page 29: Attività Fisica e tumore della mam
Page 32 and 33: I meccanismi con cui l’attività
Page 36 and 37: Determinanti della densità mammogr
Page 38 and 39: La densità mammografica è stata p
Page 40 and 41: Screening mammografico Firenze(mamm
Page 42: Raccomandazioniper la prevenzionepr
Page 46: CONCLUSIONIUna serie di fattori di

fattori di rischio modificabili per il tumore della mammella

Create successful ePaper yourself

Delete template?

Save as template?