H5N1 NS1蛋白的功能验证 - abc

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4. 参考文献‣ Ao Cheng et al.Structural basis for dsRNA recognition by NS1protein of influenza A virus. Cell Research,2009,19:187-195‣ Zachary A. Bornholdt et al.X-ray structure of NS1 from a highlypathogenic <strong>H5N1</strong> influenza virus.Nature,2008,456:985-988‣ Zachar y A Bor nholdt et al.X-ray structure of influenza virus NS1effector domain.Nature Structural & Molecular Biology,2006,13:599-560‣ Benjamin G. Hale et al.Structural insights into phosphoinositide 3-kinase activation by the influenza A virus NS1protein.PNAS,2010,107:1954-1959‣ Yu J, Li X, Wang Y, Li B, Li H, et al. (2011) PDlim2 SelectivelyInteracts with the PDZ Binding Motif of Highly Pathogenic Avian<strong>H5N1</strong> Influenza A Virus NS1. PLoS ONE 6(5):e19511.doi:10.1371/journal.pone.0019511
5. 致谢‣ 感谢罗老师在这一学期对我们的悉心指导‣ 感谢我们小组成员的通力合作
Page 1 and 2: H5N1 NS1 蛋白的功能验
Page 3 and 4: 1. 研究背景NS1 是 AIV 的
Page 5 and 6: 2. 研究目的通过用生
Page 7 and 8: 3.1 序列比对
Page 9 and 10: 3.1 序列比对保守位点
Page 11 and 12: 3.2 信号肽分析
Page 13 and 14: 3.3 跨膜分析
Page 15 and 16: 3.4 用 weblab 进行分析Segme
Page 17 and 18: 3.4.2 Sixpack
Page 19 and 20: 3.4.4 分析‣ 因为编码 NS
Page 21 and 22: 3.5.1 背景
Page 23 and 24: 3.5.2 N 端• 从 PDB 中找到
Page 25 and 26: 3.5.2 35Arg-G6
Page 27 and 28: 3.5.2 R38A
Page 29 and 30: 3.5.3 C 端‣ 验证突变 W182
Page 31: 3.5.3 分析‣ Trp 是极性

H5N1 NS1蛋白的功能验证 - abc

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