Espozione Professionale a Metalli Pesanti e Sclerosi ... - Anmil

Tesi Sperimentale di SpecializzazioneEsposizione Professionale a Metalli Pesanti e Sclerosi Laterale Amiotrofica64sclerosis and structural defects in Cu, Zn superoxide dismutase.Science;261:1047-1051[14] Rosen DR, Siddique T, Patterson D et al. Mutations in Cu/Znsuperoxide dismutase gene are associated with familial amyotrophiclateral sclerosis. Nature 1993;362:59-62[15] Vucic S, Kiernan MC. Pathophysiology of neurodegeneration infamilial amyotrophic lateral sclerosis. Curr Mol Med 2009Apr;9(3):255-72[16] Hadano S, Hand CK, Osuga H et al. A gene encoding a putativeGTPase regulator is mutated in familial amyotrophic lateral sclerosis.Nature Genetics 2001;29:166-173.[17] Oosthuyse B, Moons L, Sorkebaum E, Beck H, Nuyens D, et al.Deletion of the hypoxia-response element in the vascular endothelialgrowth factor promoter causes motor neuron degeneration. Nat Genet2001;28:131-38[18] Brooks BR, Miller RG, Swash M, Munsat TL for the World Federationof Neurology Research Group on Motor Neuron Disease. El Escorialrevisited: revised criteria for the diagnosis of amyotrophic lateralsclerosis. ALS and other motor neuron disease 2000;1:293-299.[19] Smith MC. Nerve fibre degeneration in the brain in the amyotrophiclateral sclerosis. Journal of neurology, Neurosurgery and Psichiatry1960; 23:269-82.