ACHEMA Daily 2022 #3

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42 ACHEMA DAILY #3 | WEDNESDAY, AUGUST 24, 2022 Lab/Pharma/Packaging The “Blister meets Paper” packaging has a barrier and a heat-sealable layer, which makes its barrier properties comparable to those of classic mono- PVC or aluminum blisters Since packaging offers an important lever to act in an eco-friendly way, pharmaceutical manufacturers have been eager to seek alternatives to traditional packaging materials and styles. Recyclable mono-laminates or even paper can pave the way to a more sustainable future. Sustainability in the pharmaceuticals industry includes many facets, from decarbonizing operations by using renewable energies, to reducing or changing packaging materials. In this respect, recyclable and/ or biodegradable solutions are pushing to the fore. At the same time, they pose a challenge for pharmaceutical manufacturers: how can they replace existing materials, like traditional plastics, without compromising on efficiency and product quality, two pillars of pharmaceuticals production? The Need for Flexibility Besides packaging quality and rigorous hygienic standards, efficiency has always been a key requirement in the pharmaceuticals industry. On the one hand, life-saving medicines call for efficient processes and often high outputs to ensure steady market supply. With this driver, the industry in recent Paper-based Solutions With No Loss of Quality Sustainability in Pharmaceutical Packaging Source: Syntegon times has seen strong demand for highly flexible operations. Pharmaceuticals manufacturers need equipment that allows them to quickly change between products, filling methods and packaging formats. In addition, fast and easy cleaning plays a major role to ensure high product quality and ultimately, the safety of patients. On the other hand, technological, regulatory and market changes make flexibility essential: packaging machines must be easily adaptable to new packaging materials or formats. While polyvinyl chloride (PVC) may be the packaging material of choice for standard blister packs, for example, changing regulations and market demands may in future lead to that role being taken over by recyclable polypropylene (PP) or even paper. Any changes to packaging materials call for equipment that can easily process a wide range of options while ensuring smooth and efficient operations. As a trend-conscious packaging solution provider, Syntegon has been actively monitoring these developments and devised technologies that help pharmaceuticals manufacturers meet their efficiency, flexibility, and sustainability goals at the same time. Paper forming technology makes it possible to produce a wide range of innovative packaging styles terials; barriers can be perfectly tailored to customer needs to ensure the necessary protection and high quality of the packaged product. For additional shelf appeal, paper forming allows the use of personalised high-quality packaging designs and embossing. It All Starts With Questions Changing a running system, however, poses various chal- Impressive Market Response Mono-laminates and Paper Syntegon began investing in the development of equipment solutions at an early stage to support sustainable pharmaceutical production. This includes applying its know-how in processing sustainable packaging materials to demanding pharmaceutical tasks where non-recyclable plastics have been the norm. The company recently developed a solution called “Blister meets Paper,” which sparked an impressive response on the market and received the German Packaging Award in 2021. The paper-based push-through blister packaging for tablets and capsules is particularly suitable for nutraceuticals. It comes with a barrier and a heat-sealable layer, which makes the paper blister’s barrier properties comparable to those of classic mono-PVC or aluminum blisters. Both the base and lidding material can be recycled. Thanks to the combination of the TPU 1000 form, fill and seal machine for paper packaging, the 3D formable FibreForm paper from paper manufacturer Billerudkorsnäs, and the sealable barrier coating from partner Huhtamaki, paper with the geometry required for many conventional tablets can be formed. With a double-cavity clamshell design, Syntegon even offers a paper-based solution for capsules. Paper blisters can be readily processed on Syntegon machines and represent a sustainable alternative to the nonrecyclable plastics and aluminum that are widely used. The paper forming technology also meets the industry’s need for flexibility, as it makes it possible to create different shapes and package styles for tablets and capsules. Available machine designs target a mid-output range. The TPU 1000 form, fill and seal system, for instance, mechanically produces paper pods and blisters at rates of up to 15,000 packages per hour while ensuring tight seals. Paper pods can be sealed with any heat-sealable lidding malenges that pharmaceuticals companies and equipment providers need to address before any sustainably packaged tablet or capsule can go to market. While switching from plastic to paper may sound simple, it often involves several questions that all parties involved need to consider. Will the barrier be sufficient for a specific product? What opening feature should the package have? What type of product can the paperformed cavity hold? How many cavities can a blister sheet offer? Answering these questions and validating the packaging’s use and performance calls for a proof-of-concept procedure. Syntegon has devised such an approach, which “The award-winning ‘Blister meets Paper’ solution effectively combines sustainable packaging know-how with pharmaceutical applications expertise” Torsten Sauer, Director Sustainability, Syntegon Technology Source: Syntegon covers everything from designing the package to producing filled samples or small batches on a laboratory scale. Confirming these parameters is important and needs to be considered when exploring go-to-market concepts. The company is confident that we will see the first paper-based blisters on store shelves in 2023. dh Syntegon Hall 3.1, Stand C71

ACHEMA DAILY #3 | WEDNESDAY, AUGUST 24, 2022 Lab/Pharma/Packaging 43 Protect Samples During Transport or Analysis Sterile Sampling Bags for Liquids or Solids RollBags feature a waterproof enclosure to securely protect samples RollBag is a PolySilk bag made of high-density polyethylene (HDPE) with a polyproplene sticker closure for collecting, transporting and analyzing liquid, semi-solid or or solid samples. The 11 different bag sizes adapt to all types of samples and the marking zone enables easy identification of Source: Interscience samples. Developed to guarantee optimal working conditions as soon as the sample is collected, RollBag’s waterproof sticker closure effectively preserves samples during transport from the sampling site to the laboratory. Users simply close the bag with the built-in sticker for a waterproof, extraresistant closure, without any extra tools. Since the bags are metal-free, disposal is easier than with metallic wire bags. Metallic wires can puncture through bags during autoclave cycles, which introduces a potential biohazard risk, as the bag must be then disposed as sharp-object waste, resulting in a higher waste-treatment cost. RollBags can be treated as soft waste that can be crushed and incinerated, which allows the waste category to be downgraded to a more economical category, saving on costs. mpb Interscience Hall 4.1, Stand H78 Mehrstufige Codierung Proben anhand ihrer ID tracken Eine sichere und eindeutige Proben-ID ist der Schlüssel zu erfolgreichen Ergebnissen im Labor. Das Safecode-System von Eppendorf ermöglicht eine sichere Nachverfolgung der Probengefäße in allen Phasen des Arbeitsablaufs im Labor: vom Labortisch bis zur Langzeitlagerung im ULT-Gefrierschrank. Safecode basiert auf einer mehrstufigen Codierung der Verbrauchsmaterialien auf der Grundlage von vorgedruckten Datamatrix-Codes. Die Codierung kann mit dem Eppendorf- Rackscan-Gerät, einem beliebigen tragbaren Datamatrix- Scanner oder sogar mit einem Smartphone gelesen werden. Die Safecode-Familie von Kryoröhrchen wird nun durch eine Reihe von barcodierten klassischen konischen Röhrchen erweitert: 5, 15 und 50 ml für den täglichen Routinegebrauch am Labortisch. Die konischen Eppendorf-Röhrchen sind digitalisiert – sowohl auf den Röhrchen als auch zu Dokumentationszwecken. Alle Safecode-Verbrauchsmaterialien können über den Eppendorf-Dataport zurückverfolgt werden: Spezifisches Begleitmaterial wie Chargennummer, Zertifikate, technische Zeichnungen usw. sind online auf Basis der Verbrauchsmaterial- Das Safecode-System ermöglicht eine sichere Nachverfolgung der Probengefäße ID verfügbar. Ergänzt durch diese Dokumentationsdateien, die sich auf das spezifische Gefäß beziehen, kann die Proben- ID automatisch in die Elabnext- Software übertragen werden, um den Probenort und die Prozessdokumentation zu dokumentieren. Alle unterstützenden Dateien des Gefäßes werden automatisch mit dieser Probe verknüpft. Das Safecode-System wird ergänzt durch die Cryocube-F740-ULT-Gefriergeräte, Visionize-Gefrierschrank-Benachrichtigungs-/Überwachungsanwendungen sowie die Elabnext-Software als weitere Bausteine für eine intelligente und zuverlässige Probenhandhabungslösung im Labor. bec Eppendorf Halle 4.1, Stand B35 Thermocycler-Management-Software Vereinfacht den Laboralltag Die Software Biometra TSuite ermöglicht die Bedienung und Überwachung vernetzter Thermocycler ChemicalEngineering-AchemaDaily_134x91mm.pdf - August 9, 2022 x Bild: Eppendorf Your Partner for Drying and Processing Technology Containment Systems Not on the spot in Frankfurt, but always at your service! For any kind of request, please contact us: Circulating Air Ovens Bild: Analytik Jena Die Software Biometra TSuite von Analytik Jena ermöglicht die vielseitige Bedienung sowie Überwachung vernetzter Thermocycler (PCR) direkt vom Büroarbeitsplatz aus. Die komfortable und benutzerfreundliche Software bietet eine große Bandbreite an Funktionen: Biometra TSuite ermöglicht nicht nur einen schnellen Einstieg in die sofortige Bedienung einzelner Thermocycler in einem Netzwerk, sondern zusätzlich den Zugang zu detaillierten Geräteinformationen, Programmen, Dokumentationsdateien und vielem mehr. Selbstverständlich ist auch die Integrität sowie Sicherheit der enthaltenen und zu übermittelnden Daten gewährleistet. Die Kombination von Symbolen, Farbkodierungen und thematisch gruppierten Inhalten innerhalb des Tools erlaubt eine einfache Erfassung umfangreicher Daten auf einen Blick. Somit ist eine schnelle Handhabung der Software möglich – umfangreiche Schulungen sind nicht nötig. Es können bis zu 1000 Geräte von Biometra TSuite verwaltet werden, sodass es keine Beschränkung in der Anzahl an zu integrierenden Geräten, auch über Etagen hinweg, gibt. Dies resultiert in einer deutlichen Zeitersparnis und hohem Komfort in der Bedienung der Thermocycler sowie einer verlässlichen und übersichtlichen Dokumentation verschiedener Log-Dateien. bec Analytik Jena Halle 4.1, Stand K16 Vacuum Drying Ovens PINK GmbH Thermosysteme Am Kessler 6 · 97877 Wertheim-Bestenheid · Germany info@pink.de · www.pink.de