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Q koorts - SWAB

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Effect<br />

Conc.<br />

Effect<br />

Relatie tussen farmacokinetiek en farmacodynamie:<br />

de weg naar doeltreffendheid...<br />

0.4<br />

Pharmacokinetics<br />

conc. vs time<br />

Pharmacodynamics<br />

conc. vs effect<br />

0.0<br />

0 25<br />

Time<br />

Conc. (log)<br />

10-3<br />

1<br />

PK/PD<br />

effect vs time<br />

0<br />

0<br />

Time<br />

Adapted from H. Derendorf ( 2d ISAP Educational Workshop, 2000)<br />

17-06-2010 Therapeutic Drug Monitoring: A pharmacodynamic approach (<strong>SWAB</strong>, Utrecht) 225

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