Q koorts - SWAB

no. of observations
no. of observations
2. Continu infuus van vancomycine…
Infusion will push music to its limits
• zal de werkzaamheid maximaliseren… door
gemakkelijker toedieningschema en
dosisaanpassing…
Een "klinishe apotheker" studie over "klassieke toediening"
van vancomycine (2 X / dag en "piek en dal" staalname)
eligible patients: 102
timing of vancomycin peak
timing of vancomycin trough
inclusion: 94 patients
exclusions:
• 2 for inability to perform
observation
• 6 for limited life expectancy
20
16
40
30
111 treatments
12
8
20
vancomycin: 46
peak: 44
amikacin: 65 trough: 62
4
0
-150 to -90
-90 to -30
-30 to + 30
+30 to +90
+90 to +150
> 150
deviation from scheduled time (min)
10
0
-60 to -30
-30 to +30
+30 to +60
+120 to +180
+60 to 120
> 180
deviation from scheduled time (min)
Ampe et al., in preparation
43 % fouten in
tijd afnaam staalname tijd ...
17-06-2010 Therapeutic Drug Monitoring: A pharmacodynamic approach (SWAB, Utrecht) 248