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sindromul ascitic - UMF - Iuliu Haţieganu

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ARCINOGENEZA HEPATICĂ – PROCES ÎN TREPTE<br />

Factori majori<br />

VHB, VHC, alcool,<br />

aflatoxine<br />

Necroză/regenerare<br />

Inflamaţie<br />

Stres oxidativ<br />

Citokine<br />

Factori de creştere<br />

Modificări genetice şi<br />

epigenetice<br />

Mutaţii<br />

p53<br />

β-catenină<br />

axină<br />

icat normal Hepatită cronică Ciroză<br />

Displazie cu celule<br />

mici<br />

Carcinom<br />

hepatocelular<br />

Modificat după Marie Annick Buendia

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