Evaluation of bactericidal and fungicidal activity of ferrocenyl or phenyl derivatives...

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Table 1 (continued) Cpd. Num. R 3 R 2 R1 2 R 1 ¼ OH; R 2 ¼ OH R 3 ¼ Fc 19 R 1 ¼ H; R 2 ¼ NH2 R 3 ¼ Ph 3 R 1 ¼ H; R 2 ¼ NH2 R 3 ¼ Fc 20 R 1 ¼ H; R 2 ¼ NHAc R 3 ¼ Ph 4 R 1 ¼ H; R 2 ¼ NHAc R 3 ¼ Fc 7 R 1 ¼ H; R 2 ¼ NHCOEt R 3 ¼ Fc 8 R 1 ¼ H; R 2 ¼ NHCOiPr R 3 ¼ Fc 9 R 1 ¼ H; R 2 ¼ NHCO t Bu R 3 ¼ Fc 22 R 1 ¼ OH R 2 ¼ O(CH2)3NMe2 R 3 ¼ Ph 1 R 1 ¼ OH R 2 ¼ O(CH2)3NMe2 R 3 ¼ Fc 21 R 1 ¼ O(CH2)3NMe2 R 2 ¼ O(CH2)3NMe2; R 3 ¼ Ph 10 R 1 ¼ O(CH2)3NMe2 R 2 ¼ O(CH2)3NMe2 R 3 ¼ Fc 11 R 1 ¼ OH R 2 ¼ O(CH2)4NMe2; R 3 ¼ Fc 12 R 1 ¼ H; R 2 ¼ Br R 3 ¼ Fc 13 R 1 ¼ H; R 2 ¼ CN R 3 ¼ Fc (Z isomer) 14 R 1 ¼ OH; R 2 ¼ OCO t Bu R 3 ¼ Fc 15 R 1 ¼ OCO t Bu R 2 ¼ OCO t Bu; R 3 ¼ Fc 16 R 1 ¼ OCOC15H31 R 2 ¼ OCOC15H31 R 3 ¼ Fc 23 R 1 ¼ OCOC15H31 R 2 ¼ OCOC15H31 R 3 ¼ Ph 26 R 1 ¼ O(CH2)3NMe2H þ R 2 ¼ OH; R 3 ¼ Fc 27 R 1 ¼ O(CH2)3NMe2H þ R 2 ¼ O(CH2)3NMe2H þ R 3 ¼ Fc HO 24 Fe a MFC value; n.tox: non-toxic at 10 mM; nd: not determined. b Values from Ref. [45]. c Values from Ref. [12]. d Values from Ref. [14]. e Values from Ref. [47]. f Values from Ref. [52]. OH M. El Arbi et al. / Journal <strong>of</strong> Organometallic Chemistry 696 (2011) 1038e1048 1043 Pseudomonas aeruginosa (mg/mL (mM)) Staphylococcus aureus (mg/mL (mM)) C<strong>and</strong>ida albicans (mg/mL (mM)) IC50 on MDA-MB-231 (mM) log Po/w MIC 100 (235.67) 100 (235.67) 100 (235.67) 0.6 c 5.0 c MBC 200 (471.35) 200 (471.35) 200 a (471.35) MIC 50 (167) 50 (167) 50 (167) > 1 mM d 4.86 d MBC 200 (678) 200 (678) 200 a (678) MIC 25 (61.4) 100 (245.5) 100 (245.5) 0.8 d 5.75 d MBC 50 (122.7) 200 (491) 200 a (491) MIC 100 (292.9) 100 (292.9) 100 (292.9) 55.4 e MBC 200 (585.7) 200 (585.7) 200 a (585.7) MIC 100 (222.5) 100 (222.5) 100 (222.5) 0.65 d 5.92 d MBC 200 (445.1) 200 (445.1) 200 a (445.1) MIC 100 (215.80) 100 (215.80) 100 (215.80) 1.2 5.89 MBC 200 (431.6) 200 (431.6) 200 a (431.6) MIC 100 (209.5) 100 (209.5) 100 (209.5) 2.02 6.13 MBC 200 (418.9) 200 (418.9) 200 a (418.9) MIC 100 (203.5) 100 (203.5) 100 (203.5) > 1 mM 6.35 MBC 200 (407) 200 (407) 200 a (407) MIC
1044 from
Page 1 and 2: Evaluation of bactericidal and fung
Page 3 and 4: 1040 similar or superior to that of
Page 5: 1042 Fe THF/diethyl ether Fe 1 26 O
Page 9 and 10: 1046 suspension in oil) was added.
Page 11: 1048 [52] D. Plazuk, A. Vessières,

Evaluation of bactericidal and fungicidal activity of ferrocenyl or phenyl derivatives...

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