Sunday March 3 Oral Sessions Session 3 CROI <strong>2013</strong> c Sunday, 2:30-4:30 pm; B313 Session 3–Workshop Clinical Trials Design This workshop is designed to address several current issues in HIV clinical trial design and interpretation. These talks are intended for a general audience and will explore issues such as how to integrate data from clinical trials with mathematical models, what you need to know about adaptive trial designs, and alternatives to randomized clinical trials. These lectures will use examples from recent HIV treatment and prevention trials and will include time for Q&A. CROI registrants may attend the workshop. No pre-registration is required. Conveners: Susan Buchbinder, San Francisco Dept of Publ Hlth, CA, US Richard Chaisson, Johns Hopkins Univ Sch of Med, Baltimore, MD, US 2:35-3:10 pm 11 Adaptive Methods: What You Really Need to Know Michael Proschan Biostatistics Res Branch, NIAID, NIH, Bethesda, MD, US 3:10-3:45 pm 12 Alternatives to Randomized Controlled Trials: When and How to Use Caroline Sabin Univ Coll London, UK 3:45-4:20 pm 13 The Symbiotic Relationship between Trials and Mathematical Models Timothy Hallett Imperial Coll London, UK 2 � 20th Conference on Retroviruses and Opportunistic Infections f Sunday, 5-7 pm; Hall B1 Session 4–Opening Greetings from the Program Committee Kevin De Cock CDC Kenya, Nairobi Remarks from the Director of the US Centers for Disease Control and Prevention Thomas Frieden CDC, Atlanta, GA, US 18 th Bernard Fields Lecture The Bernard Fields lectureship recognizes a scientist whose body of work has significantly contributed to the understanding of virology and viral pathogenesis as exemplified by the career of Bernard Fields. 14 ARV Drug Discovery: HIV-1 Integrase Inhibitors and Beyond Daria Hazuda Merck Res Labs, West Point, PA, US Objectives: This session is directed to clinicians and scientists interested in ART and novel targets for drug discovery. It is assumed that participants have a basic understanding of retroviral biology and are familiar with HIV therapeutics. At the completion of the session, participants will have a deeper understanding the biology of integrase and the development of integrase inhibitors as well as increased knowledge of the drug discovery process as it applies to future therapeutics. 7 th N’Galy-Mann Lecture The N’Galy-Mann lectureship was established in 2006 to recognize an individual researcher or team who has made important and timely contributions in epidemiology and clinical research as exemplified by the collaborative careers of Bosenge N’Galy and Jonathan Mann. 15 MTCT: From Epidemic to Elimination Lynne Mofenson Natl Inst of Child Hlth and Human Devt, NIH, Rockville, MD, US Objectives: This session is directed to clinicians and scientists interested in the evolution of interventions for PMTCT in the US and globally, and lessons learned. It is assumed that participants are familiar with mechanisms of MTCT and interventions to prevent it. At the completion of the session, participants will be knowledgeable about clinical trials and implementation science related to PMTCT, lessons learned from the US, and implications globally Welcome Reception 7-10 pm Georgia Aquarium The Georgia Aquarium is a short walk (3 blocks) from the Convention Center.
CROI <strong>2013</strong> Session 8 i Monday, 8:30-9 am; Hall B1 Session 5–Plenary HIV-1 Eradication Strategies: Design, Assessment, and Clinical Consequences 16 Robert Siliciano Johns Hopkins Univ Sch of Med, Baltimore, MD, US Objectives: This session is directed to clinicians and scientists interested in HIV-1 eradication studies. It is assumed participants are familiar with fundamental aspects of HIV-1 treatment such as the response to HAART, and the need for additional interventions to eliminate the residual virus that persists despite HAART. At the completion of the session, participants will be knowledgeable about assays to measure viral reservoirs and the clinical consequences of reductions in reservoir size induced by eradication strategies. j Monday, 9-9:30 am; Hall B1 Session 6–Plenary Reality Check: Is the End of AIDS in Sight? 17 Francois Dabis Bordeaux Sch of Publ Hlth and INSERM U897, Univ Bordeaux, Segalen, France Objectives: This session is directed to clinicians and scientists interested in the global perspective of the fight against HIV/AIDS. It is assumed that participants are familiar with the concepts of prevention and care and the <strong>program</strong>matic differences between resource-rich and -limited settings. At the completion of the session, participants will be knowledgeable about the most recent advances in biomedical prevention and the foreseeable scenarios for the coming years. k Monday, 10-11:30 am; B406 Session 7–Oral Abstracts Neurocognitive Disorders: New Developments and Therapies Moderators: Christina Marra, Univ of Washington Sch of Med, Seattle, US Ann Ragin, Northwestern Univ Feinberg Sch of Med, Chicago, IL, US 10:00 18 Very Early Viral Infection of the Central Nervous System without Evidence of Compartmentalization during Acute HIV-1 Infection (RV254) Serena Spudich* 1 , G Kijak 2,3 , J Ananworanich 4,5 , M Bose 2,3 , V Assawadarachai 5 , S Rattamanee 4,5 , E Sanders-Buell 2,3 , V Valcour 6 , J Kim 2 , S Tovanabutra 2,3 , and RV254/SEARCH 010 Study Group 1 Yale Univ, New Haven, CT, US;; 2 US Military HIV Res Prgm, Walter Reed Army Inst of Res, Silver Spring, MD;; 3 Henry M Jackson Fndn for the Advancement of Military Med, Bethesda, MD, US;; 4 SEARCH, The Thai Red Cross AIDS Res Ctr, HIVNAT, Bangkok;; 5 Armed Forces Res Inst for Med Sci, Bangkok, Thailand;; and 6 Univ of California, San Francisco, US 10:15 19 Neuropsychological Performance in Acute HIV: Determinants of Baseline Performance and Effects of Immediate ART Idil Kore* 1 , J Ananworanich 2,3,4 , V Valcour 5 , J Fletcher 2 , D Suttichom 2 , P Mangum 2 , L Jagodzinski 6 , J Kim 6 , S Spudich 1 , and RV254/SEARCH 010 Study Group 1 Yale Univ Sch of Med, New Haven, CT, US;; 2 SEARCH, The Thai Red Cross AIDS Res Ctr, Bangkok;; 3 HIVNAT, Bangkok, Thailand;; 4 Faculty of Med, Chulalongkorn Univ, Bangkok, Thailand;; 5 Univ of California, San Francisco, US;; and 6 US Military HIV Res Prgm, Silver Spring, MD 10:30 20 A Randomized, Controlled Trial of a Central Nervous System-targeted ART Strategy for HIV-associated Neurocognitive Disorders Ronald Ellis* 1 , F Vaida 1 , S Letendre 1 , R Haubrich 1 , R Heaton 1 , A McCutchan 1 , M Cherner 1 , A Umlauf 1 , N Sacktor 2 , and D Clifford 3 1 Univ of California, San Diego, US;; 2 Johns Hopkins Univ, Baltimore, MD, US;; and 3 Washington Univ, St Louis, MO, US 10:45 21 Regional Brain Atrophy Is Associated with Mitochondrial Dysfunction and Elevated Mitochondrial Oxidative Stress in HIV + Individuals K Kallianpur, M Gerschenson, T Umaki, D Chow, B Nakamoto, D Libutti, M Lopez, J Taylor, L Marotz, and Cecilia Shikuma* Univ of Hawaii, Honolulu, US 11:00 22 VLA-4 Treatment Blocks Virus Traffic to the Gut and Brain Early, and Stabilizes CNS Injury Late in Infection Jennifer Campbell* 1 , P Autissier 1 , A MacLean 2 , T Burdo 1 , S Westmoreland 3 , G Gonzalez 4,5 , E-M Ratai 4,5 , and K Williams 1 1 Boston Coll, Chestnut Hill, MA, US;; 2 Tulane Natl Primate Res Ctr, Covington, LA, US;; 3 New England Regional Primate Res Ctr, Southborough, MA, US;; 4 Harvard Med Sch, Boston, MA, US;; and 5 Athinoula A Martinos Ctr for Biomed Imaging, Massachusetts Gen Hosp, Boston, US 11:15 23 Central Nervous System Compartmentalization of HIV-1 Subtype C Variants Early and Late in Infection in Young Children Christa Buckheit Sturdevant* 1 , A Dow 1 , C Jabara 1 , S Joseph 1 , G Schnell 2 , N Takamune 3 , M Mallewa 4 , R Heyderman 4 , A Van Rie 1 , and R Swanstrom 1 1 Univ of North Carolina at Chapel Hill, US;; 2 Univ of Washington, Seattle, US;; 3 Kumamoto Univ, Japan;; and 4 Univ of Malawi Coll of Med, Blantyre k Monday, 10 am-12:15 pm; Ballroom 3-4 Session 8–Oral Abstracts HIV Prevention: ARV, Counseling, Contraception, and Condoms Moderators: Monica Gandhi, Univ of California, San Francisco, Sch of Med, US James McIntyre, Anova Hlth Inst, Johannesburg, South Africa 10:00 24LB Long-acting Parenteral Formulation of GSK1265744 Protects Macaques against Repeated Intrarectal Challenges with SHIV Chasity Andrews* 1 , A Gettie 1 , K Russell-Lodrigue 2 , L Moss 3 , H Mohri 1 , W Spreen 3 , C Cheng-Mayer 1 , Z Hong 3 , M Markowitz 1 , and D Ho 1 1 Aaron Diamond AIDS Res Ctr, The Rockefeller Univ, New York, NY, US;; 2 Tulane Natl Primate Res Ctr, Covington, LA, US;; and 3 GlaxoSmithKline, Research Triangle Park, NC, US 10:15 25LB A Tenofovir Disoproxil Fumarate Intravaginal Ring Completely Protects against Repeated SHIV Vaginal Challenge in Nonhuman Primates James Smith* 1 , R Rastogi 2 , R Teller 2 , P Srinivasan 1 , J Mitchell 1 , J McNicholl 1 , M Hendry 1 , P Mesquita 3 , P Kiser 2 , and B Herold 3 1 CDC, Atlanta, GA, US;; 2 Univ of Utah, Salt Lake City, US;; and 3 Albert Einstein Coll of Med, Bronx, NY, US 10:30 26LB Pre-exposure Prophylaxis for HIV in Women: Daily Oral Tenofovir, Oral Tenofovir/ Emtricitabine, or Vaginal Tenofovir Gel in the VOICE Study (MTN 003) Jeanne Marrazzo* 1 , G Ramjee 2 , G Nair 3 , T Palanee 4 , B Mkhize 5 , C Nakabiito 6 , M Taljaard 7 , J Piper 8 , K Gomez Feliciano 9 , M Chirenje 10 , and VOICE Study Team 1 Univ of Washington, Seattle, US;; 2 HIV Prevention Res Unit, Durban, South Africa;; 3 CAPRISA-eThekwini CRS, Duban, South Africa;; 4 Witwatersrand Reproductive Hlth & HIV Inst;; 5 Perinatal HIV Res Unit, Johannesburg, South Africa;; 6 Makerere-Johns Hopkins Univ Res Collaboration, Kampala, Uganda;; 7 Aurum Inst, Klerksdorp, South Africa;; 8 Division of AIDS, NIH, Bethesda, MD, US;; 9 FHI360, Research Triangle Park, NC, US;; and 10 Univ of Zimbabwe-UCSF CTU, Harare 10:45 27 No Excess in HIV Incidence after Stopping Oral Emtricitabine/Tenofovir Pre-exposure Prophylaxis: The iPrEx Trial Robert Grant* 1,2 , J Guanira 3 , S Buchbinder 2,4 , C Mosquera 3 , V Veloso 5 , E Kallas 6 , M Mehrotra 1 , V McMahan 1 , R Amico 7 , D Glidden 2 , and iPrEx Study Team 1 Gladstone Inst, San Francisco, CA, US;; 2 Univ of California, San Francisco, US;; 3 INMENSA, Lima, Peru;; 4 San Francisco Dept of Publ Hlth, CA, US;; 5 FIOCRUZ, Rio de Janeiro, Brazil;; 6 Univ of Sao Paulo, Brazil;; and 7 Univ of Connecticut, Storrs, US Program � 3 Monday March 4 Oral Sessions
- Page 1 and 2: Pocket Program CR I 2O13 20th Confe
- Page 3 and 4: vi General Information CROI 2013 AB
- Page 5 and 6: viii General Information CROI 2013
- Page 7 and 8: x Hotel Information CROI 2013 Map K
- Page 9: CROI 2013 Session 2 j Sunday, 9 am-
- Page 13 and 14: CROI 2013 Session 12 k Monday, 10 a
- Page 15 and 16: CROI 2013 Session 16 b Monday, 1:30
- Page 17 and 18: CROI 2013 Session 20 e Monday, 4-6
- Page 19 and 20: CROI 2013 Session 26 11:00 85 Impac
- Page 21 and 22: CROI 2013 Session 31 1023 Risk Fact
- Page 23 and 24: CROI 2013 Session 34 e Tuesday, 4-6
- Page 25 and 26: CROI 2013 Session 40 i Wednesday, 8
- Page 27 and 28: CROI 2013 Session 45 11:00 153LB Om
- Page 29 and 30: CROI 2013 Session 49 1103 Attrition
- Page 31 and 32: CROI 2013 Session 52 e Wednesday, 4
- Page 33 and 34: CROI 2013 Session 57 188LB���
- Page 35 and 36: CROI 2013 Session 65 c Tuesday, 2:3
- Page 37 and 38: CROI 2013 Session 70 c Wednesday, 2
- Page 39 and 40: CROI 2013 Session 75 329 Impact of
- Page 41 and 42: CROI 2013 Session 82 369� ��
- Page 43 and 44: CROI 2013 Session 89 413 Risk of Cl
- Page 45 and 46: CROI 2013 Session 93 456 A Longitud
- Page 47 and 48: CROI 2013 Session 100 c Tuesday, 2:
- Page 49 and 50: CROI 2013 Session 106 c Monday, 2:3
- Page 51 and 52: CROI 2013 Session 111 c Wednesday,
- Page 53 and 54: CROI 2013 Session 117 616� ��
- Page 55 and 56: CROI 2013 Session 122 656 Compariso
- Page 57 and 58: CROI 2013 Session 125 c Tuesday, 2:
- Page 59 and 60: CROI 2013 Session 131 c Monday, 2:3
- Page 61 and 62:
CROI 2013 Session 137 c Tuesday, 2:
- Page 63 and 64:
CROI 2013 Session 144 809 Prevalenc
- Page 65 and 66:
CROI 2013 Session 150 847 Improving
- Page 67 and 68:
CROI 2013 Session 161 885 The Impac
- Page 69 and 70:
CROI 2013 Session 171 + 924� �
- Page 71 and 72:
CROI 2013 Session 180 c Wednesday,
- Page 73 and 74:
CROI 2013 Session 187 994� ��
- Page 75 and 76:
CROI 2013 Session 192 1032b Changes
- Page 77 and 78:
CROI 2013 Session 197 1074� �
- Page 79 and 80:
CROI 2013 Session 199 nd 1113�
- Page 81 and 82:
POSTER SESSIONS Poster Hall open fr