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Sunday<br />

March 3 Oral Sessions<br />

Session 3 CROI <strong>2013</strong><br />

c Sunday, 2:30-4:30 pm; B313<br />

Session 3–Workshop<br />

Clinical Trials Design<br />

This workshop is designed to address several current issues in HIV<br />

clinical trial design and interpretation. These talks are intended for<br />

a general audience and will explore issues such as how to integrate<br />

data from clinical trials with mathematical models, what you need<br />

to know about adaptive trial designs, and alternatives to randomized<br />

clinical trials. These lectures will use examples from recent HIV<br />

treatment and prevention trials and will include time for Q&A.<br />

CROI registrants may attend the workshop. No pre-registration is<br />

required.<br />

Conveners:<br />

Susan Buchbinder, San Francisco Dept<br />

of Publ Hlth, CA, US<br />

Richard Chaisson, Johns Hopkins Univ<br />

Sch of Med, Baltimore, MD, US<br />

2:35-3:10 pm<br />

11<br />

Adaptive Methods: What You Really Need to<br />

Know<br />

Michael Proschan<br />

Biostatistics Res Branch, NIAID, NIH, Bethesda, MD, US<br />

3:10-3:45 pm<br />

12<br />

Alternatives to Randomized Controlled Trials:<br />

When and How to Use<br />

Caroline Sabin<br />

Univ Coll London, UK<br />

3:45-4:20 pm<br />

13<br />

The Symbiotic Relationship between Trials<br />

and Mathematical Models<br />

Timothy Hallett<br />

Imperial Coll London, UK<br />

2 � 20th Conference on Retroviruses and Opportunistic Infections<br />

f Sunday, 5-7 pm; Hall B1<br />

Session 4–Opening<br />

Greetings from the Program Committee<br />

Kevin De Cock<br />

CDC Kenya, Nairobi<br />

Remarks from the Director of the US Centers<br />

for Disease Control and Prevention<br />

Thomas Frieden<br />

CDC, Atlanta, GA, US<br />

18 th Bernard Fields Lecture<br />

The Bernard Fields lectureship recognizes a scientist whose body of<br />

work has significantly contributed to the understanding of virology<br />

and viral pathogenesis as exemplified by the career of Bernard Fields.<br />

14<br />

ARV Drug Discovery: HIV-1 Integrase<br />

Inhibitors and Beyond<br />

Daria Hazuda<br />

Merck Res Labs, West Point, PA, US<br />

Objectives: This session is directed to clinicians and scientists<br />

interested in ART and novel targets for drug discovery. It is assumed<br />

that participants have a basic understanding of retroviral biology<br />

and are familiar with HIV therapeutics. At the completion of the<br />

session, participants will have a deeper understanding the biology<br />

of integrase and the development of integrase inhibitors as well as<br />

increased knowledge of the drug discovery process as it applies to<br />

future therapeutics.<br />

7 th N’Galy-Mann Lecture<br />

The N’Galy-Mann lectureship was established in 2006 to recognize<br />

an individual researcher or team who has made important and timely<br />

contributions in epidemiology and clinical research as exemplified<br />

by the collaborative careers of Bosenge N’Galy and Jonathan Mann.<br />

15<br />

MTCT: From Epidemic to Elimination<br />

Lynne Mofenson<br />

Natl Inst of Child Hlth and Human Devt, NIH, Rockville, MD, US<br />

Objectives: This session is directed to clinicians and scientists<br />

interested in the evolution of interventions for PMTCT in the US<br />

and globally, and lessons learned. It is assumed that participants are<br />

familiar with mechanisms of MTCT and interventions to prevent it.<br />

At the completion of the session, participants will be knowledgeable<br />

about clinical trials and implementation science related to PMTCT,<br />

lessons learned from the US, and implications globally<br />

Welcome Reception<br />

7-10 pm<br />

Georgia Aquarium<br />

The Georgia Aquarium is a short walk (3 blocks) from the Convention Center.

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