SATS 2009 Final Program - Scandinavian Association for Thoracic ...

S06
SCANSECT ORAL ABSTRACT SESSION
S06:1
FIBRINOGEN AND THE ACUTE INFLAMMATORY RESPONSE AFTER CARDIAC SURGERY
Kalabic Maria 1 , Jeppsson Anders 1 , Rexius Helena 1
1) Sahlgrenska University Hospital, Sweden
Objective
Fibrinogen concentrate can be used to prevent or treat bleeding after cardiac surgery but it may also raise plasma
concentrations to supra-normal levels, potentially leading to hypercoagulability. Fibrinogen is an acute phase reactant
and plasma concentration increases in response to the surgical trauma. The aim of the study was to establish the
normal response of fibrinogen to cardiac surgery and its potential association to other acute phase reactants.
Methods
Fifteen on-pump CABG patients were included in a prospective observational study. Plasma concentrations of
fibrinogen, C-reactive protein (CRP) and interleukin-6 (IL-6) were measured before surgery (baseline) and day 1 to
day 4 after surgery. Plasma concentrations at the different time points were compared to baseline and correlation
calculations between fibrinogen, CRP and IL-6 were performed.
Results
Fibrinogen plasma concentration increased during the study period from 3.9±0.6 to 7.8±1.9 g/L (p