SATS 2009 Final Program - Scandinavian Association for Thoracic ...
SATS 2009 Final Program - Scandinavian Association for Thoracic ...
SATS 2009 Final Program - Scandinavian Association for Thoracic ...
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S06:2<br />
PLATELET AGGREGABILITY BEFORE AND AFTER CORONARY ARTERY BYPASS SURGERY<br />
Önsten Linda 1 , Jeppsson Anders 1 , Rexius Helena 1<br />
1) Sahlgrenska University Hospital, Sweden<br />
Objective<br />
Platelet dysfunction may contribute to bleeding complications after Coronary artery bypass grafting (CABG).<br />
Impedance aggregometry is a new point-of-care method to assess platelet function. We determined platelet<br />
impedance aggregation be<strong>for</strong>e and after CABG surgery.<br />
Methods<br />
10 patients treated with aspirin and adenosine-diphosphate (ADP) receptor blocker clopidogrel and 9 patients treated<br />
with aspirin within 7 days be<strong>for</strong>e surgery were included in this prospective observational study. Platelet aggregation<br />
was compared between individual time points and between patients with or without clopidogrel treatment. Impedance<br />
aggregometry (Multiplate�), with ADP and thrombin receptor activated peptide 6 (TRAP) as activators.<br />
Results<br />
ADP-induced platelet aggregation at sternum closure was reduced compared to the day be<strong>for</strong>e surgery, to anesthesia<br />
induction and to the day after surgery (20±15 units vs. 41±24, 36±17 and 43±18, respectively (p
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