annual meeting program - American Society of Clinical Oncology

9:45 AM - 11:15 AM
CLINICAL SCIENCE SYMPOSIUM
Smoothened/Hedgehog/Gamma Secretase
Location: E353
CME credit: 1.5
Track(s): Developmental Therapeutics
Sunday, June 6, 2010
S. Gail Eckhardt, MD—Chair
University of Colorado Cancer Center
Discussion
9:45 AM Patricia LoRusso, DO
Karmanos Cancer Institute
Introduction
10:00 AM A phase I dose-escalation study of LDE225, a smoothened (Smo) antagonist,
in patients with advanced solid tumors. (Abstract #2500)
J. Rodon Ahnert, J. Baselga, H. A. Tawbi, Y. Shou, C. Granvil, J. Dey, M. M. Mita,
A. L. Thomas, D. D. Amakye, A. C. Mita
10:15 AM A first-in-human, phase I study of an oral hedgehog (HH) pathway antagonist,
BMS-833923 (XL139), in subjects with advanced or metastatic solid tumors.
(Abstract #2501)
L. L. Siu, K. Papadopoulos, S. R. Alberts, R. Kirchoff-Ross, B. Vakkalagadda,
L. Lang, C. M. Ahlers, K. L. Bennett, J. M. Van Tornout
10:30 AM A phase I study of RO4929097, a novel gamma secretase inhibitor, in patients
with advanced solid tumors. (Abstract #2502)
A. W. Tolcher, S. M. Mikulski, W. A. Messersmith, E. L. Kwak, D. Gibbon,
J. Boylan, Z. X. Xu, M. DeMario, J. J. Wheler
Discussion
10:45 AM Charles M. Rudin, MD, PhD (Abstracts #2500–2502)
Sidney Kimmel Cancer Center at Johns Hopkins
Closing Remarks
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SUNDAY