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annual meeting program - American Society of Clinical Oncology

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MONDAY<br />

Monday, June 7, 2010<br />

3:00 PM - 6:00 PM<br />

ORAL ABSTRACT SESSION<br />

Tumor Biology<br />

Location: S100a<br />

CME credit: 3<br />

Track(s): Tumor Biology<br />

Robert Arthur Kratzke, MD—Co-Chair<br />

University <strong>of</strong> Minnesota<br />

Jorge Reis-Filho, MD, PhD—Co-Chair<br />

Breakthrough Breast Cancer Research Centre<br />

3:00 PM Use <strong>of</strong> gene expression signatures to identify origin <strong>of</strong> primary and<br />

therapeutic strategies for patients with advanced solid tumors. (Abstract<br />

#10504)<br />

S. D. Hsu, M. K. Kim, A. Foye, A. Silvestri, H. K. Lyerly, M. Morse, E. Petricoin III,<br />

P. G. Febbo<br />

3:15 PM Comparative analysis <strong>of</strong> the chromosomal origins <strong>of</strong> circulating nucleic<br />

acids in breast and prostate cancer. (Abstract #10505)<br />

E. Schütz, J. Beck, W. M. Mitchell, H. B. Urnovitz<br />

3:30 PM Use <strong>of</strong> integrated genomic analysis to evaluate BRCA-associated protein 1<br />

(BAP1) as a mutated gene in malignant pleural mesothelioma (MPM).<br />

(Abstract #10506)<br />

M. J. Bott, M. Brevet, B. S. Taylor, S. Shimizu, T. Ito, Q. Zhou, A. Olshen,<br />

M. F. Zakowski, V. W. Rusch, M. Ladanyi<br />

3:45 PM Characterizing the clinical relevance <strong>of</strong> epithelial-mesenchymal transition<br />

(EMT) in human tumors. (Abstract #10507)<br />

K. A. Higgins, K. S. Walters, A. Potti<br />

Discussion<br />

4:00 PM David N. Hayes, MD (Abstracts #10504–10507)<br />

University <strong>of</strong> North Carolina<br />

4:15 PM Pre-existence <strong>of</strong> invasive cells in breast ductal carcinoma in situ. (Abstract<br />

#10508)<br />

V. A. Espina, R. I. Gallagher, B. D. Mariani, K. Tran, C. Mueller, S. Banks,<br />

L. Pastore, K. H. Edmiston, L. A. Liotta<br />

4:30 PM Relationship <strong>of</strong> breast cancer stem cells (CSCs) and chronic O2/glucose deprivation (C-OGD). (Abstract #10509)<br />

M. Quintela-Fandino, E. Arpaia, R. Cairns, H. Blaser, M. W. Tusche, R. Colomer,<br />

A. Rufini, A. Wakeham, T. W. Mak<br />

Discussion<br />

4:45 PM Sridhar Ramaswamy, MD (Abstracts #10508–10509)<br />

Massachusetts General Hospital<br />

5:00 PM Evaluation <strong>of</strong> BRCA1 inactivation by promoter methylation as a marker <strong>of</strong><br />

triple-negative and basal-like breast cancers. (Abstract #10510)<br />

T. A. Grushko, C. Nwachukwu, S. Charoenthammaraksa, D. Huo, A. Khramtsov,<br />

H. Mashek, C. Zhang, J. Xu, C. M. Perou, O. I. Olopade<br />

5:15 PM PARP expression in early breast cancer and its predictive value for response<br />

to neoadjuvant chemotherapy. (Abstract #10511)<br />

S. Loibl, B. Mueller, G. Von Minckwitz, J. U. Blohmer, A. d. Bois, J. B. Huober,<br />

F. Fend, J. Budczies, C. Denkert<br />

5:30 PM Protein signal pathway mapping <strong>of</strong> human breast cancer from I-SPY:<br />

Correlations with response and genomic subtyping. (Abstract #10512)<br />

J. D. Wulfkuhle, M. E. Lenburg, M. Pierobon, J. Illi, J. Zhu, A. DeMichele,<br />

V. A. Espina, L. A. Liotta, L. Esserman, E. Petricoin III, I-SPY Investigators<br />

Discussion<br />

5:45 PM James M. Ford, MD (Abstracts #10510–10512)<br />

Stanford University Medical Center<br />

412

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