CPDD 72nd Annual Meeting • Scottsdale, Arizona - The College on ...

77
INTERNET-BASED POST-MARKETING SURVEILLANCE OF
NEWLY MARKETED OPIOID ANALGESICS.
John S Brownstein, E McNaughton, T A Cassidy, S H Budman, S F Butler;
Inflexxion, Inc., Newton, MA
Aims: <strong>The</strong> National Addictions Vigilance Intervention & Prevention PROgram
(NAVIPPRO) post-marketing surveillance system monitors a several data
streams, including two, near real-time, Internet-based, product-specific datasets:
(1) Web-Informed Services (WIS) monitors Internet prescription drug abuse
chatter on abuse related websites, and (2) Geotemporal Real-time Internet-based
Intelligence for Drugs (Media-GRIID) tracks abuse-related media reports
over 20,000 news outlets. How these data streams may anticipate abuse rates as
new prescription opioid products increase market share is not well understood.
Methods: We examined the relationship of these Internet-based data streams to
abuse as measured by NAVIPPRO’s ASI-MV® Connect which collects abuse
data in the past 30 days from clients in treatment at a network of more than 530
addiction treatment facilities across the US. Data for two opioid products,
Opana® ER and EMBEDA, are examined from product-launch to explore
how Internet chatter and media reports may anticipate abuse rates. Time series
analyses were conducted for the respective life-span of each product (Opana®:
July 2006-present; EMBEDA: August 2009-present). Cross correlations compared
each data stream adjusting for time lags between the data sources and the
ASI-MV® Connect measure of prescription opioid abuse.
Results: Significant correlations over time were observed for both Internet-based
data streams and ASI-MV® abuse rates adjusting for various time lags. Analyses
identified optimal time lags of 7 months for WISTM prescription opioid web
chatter (R2=0.73) and 11 months for Media-GRIID prescription opioid-related
media mentions (R2=0.38).
Conclusions: <strong>The</strong>se preliminary results raise the possibility that Internet-based
data may provide early situation awareness intelligence with respect to abuse levels
of analgesic products as market share increases. <strong>The</strong>se data may serve as leading
indicators of trends observed in the clinical setting. Implications and robustness
of these observations are discussed with respect to Opana® ER and
EMBEDA.
Financial Support: Inflexxion, Inc.
79
HOW ACCURATE ARE ESTIMATES OF COMMUNITY ABUSE
MADE BY LOCAL KEY INFORMANTS?
Simon H Budman, T A Cassidy, K Lioy, S F Butler; Inflexxion, Inc., Newton, MA
Aims: Post-marketing surveillance of prescription medications often uses key
informants as a primary source to estimate local abuse rates. We examined how
key informant report corresponds to direct self-report of clients entering substance
abuse treatment using data from the ASI-MV® Connect, a NAVIP-
PRO(TM) data stream, which collects data from a national network of treatment
facilities.
Methods: Treatment facilities having relatively high and low rates of prescription
opioid abuse were identified. Counselors at these treatment centers served as
local key informants and estimated rates of abuse at their treatment center and
in their community on an Internet survey.
Results: Significant differences in the expected direction were obtained for estimates
of abuse rates by counselors from high- and low-rate facilities for
OxyContin® (p