Nancy Lee, MD - ASTRO
Nancy Lee, MD - ASTRO
Nancy Lee, MD - ASTRO
You also want an ePaper? Increase the reach of your titles
YUMPU automatically turns print PDFs into web optimized ePapers that Google loves.
• Randomized, N=240<br />
German Trial<br />
(Staar et al. IJROBP, 2001)<br />
• III/IV SCC unresectable bl oropharyngeal h l and d hhypopharyngeal h l<br />
carcinoma; 96% IV<br />
• 5FU(600)/Carbo(70) + concomitaant boost RT to 69.9 Gy vs RT<br />
alone<br />
Median F/U of 22.3 months<br />
• 1 yr LC 60% vs 40% ( (oropharyngeal h l ca) )<br />
• Greater Grade 3/4 mucositis 68% vs 52%; greater vomiting 8% vs<br />
1.6%<br />
• Late toxicity: 30% of the long-term survivors >/= 2 years remain<br />
dependent on a feeding tube<br />
• 51% vs 25% with swallowing problems and continuous use of a<br />
feeding tube in the RCT arm than RT arm
Change language