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Nancy Lee, MD - ASTRO

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S<br />

T<br />

R<br />

A<br />

T<br />

I<br />

F<br />

Y<br />

RTOG 91-11<br />

Phase III Trial to Preserve the Larynx<br />

R<br />

A<br />

N<br />

D<br />

O<br />

M<br />

I<br />

Z<br />

E<br />

Location:<br />

Arm 1 : Neoadjuvant CT + RT<br />

Glottic<br />

Supraglottic<br />

RT<br />

CR, PR CP + 5-FU<br />

X 1 Cycle<br />

T Stage:<br />

T2<br />

CP + 5-FU X 2 Cycles<br />

T3<br />

Early T4<br />

NR Surgery RT<br />

N Stage:<br />

Arm 2 : RT + CP<br />

N0, N1<br />

N2, N3 Arm 3 : RT Alone

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