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Nitrous Oxide - MCI

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Problems with <strong>Nitrous</strong> <strong>Oxide</strong><br />

Homocysteine & B 12 Metabolism<br />

• B 12 effect<br />

– Neurological (neuropathy) and haematologic disease (bone marrow<br />

failure) after N2O in patients with low B12 – Case reports, “prolonged” exposure<br />

– Pernicious anaemia<br />

– Resected terminal ileum<br />

– Dietary deficiency /vegan<br />

Baum Ped Anesth 2007<br />

Sanders Anesthesiology 2008

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